Stability studies of compression coated ornidazole tablets  for colon specific drug delivery

Zeynep Senyiğit; Mine Özyazıcı

Article Details

Stability studies of compression coated ornidazole tablets for colon specific drug delivery

Authors:

Zeynep Senyiğit | Mine Özyazıcı

Publisher:

Marmara University

Main Topics:

Pharmaceutical Biotechnology

Journal:

Journal of Research in Pharmacy Vol.23 Issue 1, pp.34-43

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346124

pISSN:

2630-6344

Keywords:

Abstract:

 In our previous study, colon targeted tablets of ornidazole were prepared with compression coating technique. Pectin was used as the coating layer and different ethyl cellulose EC types EC N7, N 10 and N 100 were added to Pectin to enhance mechanical and release properties. The object of the present study was performed stability testing of these coated tablets of ornidazole in a high density polyethylene plastic bottle withwithout silica gel as per ICH guidelines. For this aim, several quality-control parameters such as uniformity of weight, diameter and thickness of tablets, tablet hardness, friability, content uniformity and tablet dissolution rate are determined in stability conditions 252C  605 relative humidity and 402C  755 relative humidity. These parameters were evaluated at 0 month, 3 month, 6 month and 12 month intervals. It was concluded that the coated ornidazole tablets should be stored in a high density polyethylene plastic bottle with silica gel at controlled room temperature 25C or below their relative humidities and the presence of desiccant in the market package was essential.

 In our previous study, colon targeted tablets of ornidazole were prepared with compression coating technique. Pectin was used as the coating layer and different ethyl cellulose EC types EC N7, N 10 and N 100 were added to Pectin to enhance mechanical and release properties. The object of the present study was performed stability testing of these coated tablets of ornidazole in a high density polyethylene plastic bottle withwithout silica gel as per ICH guidelines. For this aim, several quality-control parameters such as uniformity of weight, diameter and thickness of tablets, tablet hardness, friability, content uniformity and tablet dissolution rate are determined in stability conditions 252C  605 relative humidity and 402C  755 relative humidity. These parameters were evaluated at 0 month, 3 month, 6 month and 12 month intervals. It was concluded that the coated ornidazole tablets should be stored in a high density polyethylene plastic bottle with silica gel at controlled room temperature 25C or below their relative humidities and the presence of desiccant in the market package was essential.

 In our previous study, colon targeted tablets of ornidazole were prepared with compression coating technique. Pectin was used as the coating layer and different ethyl cellulose EC types EC N7, N 10 and N 100 were added to Pectin to enhance mechanical and release properties. The object of the present study was performed stability testing of these coated tablets of ornidazole in a high density polyethylene plastic bottle withwithout silica gel as per ICH guidelines. For this aim, several quality-control parameters such as uniformity of weight, diameter and thickness of tablets, tablet hardness, friability, content uniformity and tablet dissolution rate are determined in stability conditions 252C  605 relative humidity and 402C  755 relative humidity. These parameters were evaluated at 0 month, 3 month, 6 month and 12 month intervals. It was concluded that the coated ornidazole tablets should be stored in a high density polyethylene plastic bottle with silica gel at controlled room temperature 25C or below their relative humidities and the presence of desiccant in the market package was essential.

 In our previous study, colon targeted tablets of ornidazole were prepared with compression coating technique. Pectin was used as the coating layer and different ethyl cellulose EC types EC N7, N 10 and N 100 were added to Pectin to enhance mechanical and release properties. The object of the present study was performed stability testing of these coated tablets of ornidazole in a high density polyethylene plastic bottle withwithout silica gel as per ICH guidelines. For this aim, several quality-control parameters such as uniformity of weight, diameter and thickness of tablets, tablet hardness, friability, content uniformity and tablet dissolution rate are determined in stability conditions 252C  605 relative humidity and 402C  755 relative humidity. These parameters were evaluated at 0 month, 3 month, 6 month and 12 month intervals. It was concluded that the coated ornidazole tablets should be stored in a high density polyethylene plastic bottle with silica gel at controlled room temperature 25C or below their relative humidities and the presence of desiccant in the market package was essential.

Article Details

Stability studies of compression coated ornidazole tablets for colon specific drug delivery

Authors:

Zeynep Senyiğit | Mine Özyazıcı

Publisher:

Marmara University

Main Topics:

Pharmaceutical Biotechnology

Journal:

Journal of Research in Pharmacy Vol.23 Issue 1, pp.34-43

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346124

pISSN:

2630-6344

Stability studies

compression coated ornidazole tablet

ethylcellulose

characterization of tablet

dissolution study

Issues

Article Details

Stability studies of compression coated ornidazole tablets for colon specific drug delivery

Authors: Zeynep Senyiğit | Mine Özyazıcı

Publisher: Marmara University

Main Topics: Pharmaceutical Biotechnology

Journal: Journal of Research in Pharmacy Vol.23 Issue 1, pp.34-43

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001346124

pISSN: 2630-6344

Stability studies

compression coated ornidazole tablet

ethylcellulose

characterization of tablet

dissolution study

Issues

Authors:

Zeynep Senyiğit | Mine Özyazıcı

Publisher:

Marmara University

Main Topics:

Pharmaceutical Biotechnology

Journal:

Journal of Research in Pharmacy Vol.23 Issue 1, pp.34-43

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346124

pISSN:

2630-6344