Protective role of Ferulic acid on acrylamide-induced testis toxicity in rats

Arzu Gezer; Seda Yakut; Nurcan Kılıç Bargutalp; Berrin Tarakcı Gencer

Article Details

Protective role of Ferulic acid on acrylamide-induced testis toxicity in rats

Authors:

Arzu Gezer | Seda Yakut | Nurcan Kılıç Bargutalp | Berrin Tarakcı Gencer

Publisher:

Ondokuz Mayıs University

Main Topics:

Histology and Embryology

Journal:

Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 4, pp.740-747

Document Type:

Article

Publication Date:

3/2024

Document Language:

English

Document ID (Org No.):

2001302833

pISSN:

1309-4483

Keywords:

Abstract:

 It has become important over the last few years to reduce the detrimental effects of Acrylamide ACR, which is the carcinogenic substance formed by the exposure of some foods to high temperatures. The present investigation evaluated the defensive effect of ferulic acid FA as opposed to toxicity in testis tissue triggered by ACR in male rats. ACR 100 ppm was administered in drinking water alone or with FA for 30 days orally. This study revealed that treatment with FA could remarkably decrease MDA levels and significantly increase SOD levels in the testicular tissue of the ACR-treated rats. Intaking of FA as a supplement is also supported by increasing FSHR, LHR, and AR sex hormone receptors levels. FA also reduced the harmful effects leading to ACR by decreasing histopathological changes in the testicular tissue. This study demonstrated the probable protective mechanism of FA against testicular toxicity caused by ACR.

 It has become important over the last few years to reduce the detrimental effects of Acrylamide ACR, which is the carcinogenic substance formed by the exposure of some foods to high temperatures. The present investigation evaluated the defensive effect of ferulic acid FA as opposed to toxicity in testis tissue triggered by ACR in male rats. ACR 100 ppm was administered in drinking water alone or with FA for 30 days orally. This study revealed that treatment with FA could remarkably decrease MDA levels and significantly increase SOD levels in the testicular tissue of the ACR-treated rats. Intaking of FA as a supplement is also supported by increasing FSHR, LHR, and AR sex hormone receptors levels. FA also reduced the harmful effects leading to ACR by decreasing histopathological changes in the testicular tissue. This study demonstrated the probable protective mechanism of FA against testicular toxicity caused by ACR.

 It has become important over the last few years to reduce the detrimental effects of Acrylamide ACR, which is the carcinogenic substance formed by the exposure of some foods to high temperatures. The present investigation evaluated the defensive effect of ferulic acid FA as opposed to toxicity in testis tissue triggered by ACR in male rats. ACR 100 ppm was administered in drinking water alone or with FA for 30 days orally. This study revealed that treatment with FA could remarkably decrease MDA levels and significantly increase SOD levels in the testicular tissue of the ACR-treated rats. Intaking of FA as a supplement is also supported by increasing FSHR, LHR, and AR sex hormone receptors levels. FA also reduced the harmful effects leading to ACR by decreasing histopathological changes in the testicular tissue. This study demonstrated the probable protective mechanism of FA against testicular toxicity caused by ACR.

 It has become important over the last few years to reduce the detrimental effects of Acrylamide ACR, which is the carcinogenic substance formed by the exposure of some foods to high temperatures. The present investigation evaluated the defensive effect of ferulic acid FA as opposed to toxicity in testis tissue triggered by ACR in male rats. ACR 100 ppm was administered in drinking water alone or with FA for 30 days orally. This study revealed that treatment with FA could remarkably decrease MDA levels and significantly increase SOD levels in the testicular tissue of the ACR-treated rats. Intaking of FA as a supplement is also supported by increasing FSHR, LHR, and AR sex hormone receptors levels. FA also reduced the harmful effects leading to ACR by decreasing histopathological changes in the testicular tissue. This study demonstrated the probable protective mechanism of FA against testicular toxicity caused by ACR.

Article Details

Protective role of Ferulic acid on acrylamide-induced testis toxicity in rats

Authors: Arzu Gezer | Seda Yakut | Nurcan Kılıç Bargutalp | Berrin Tarakcı Gencer

Publisher: Ondokuz Mayıs University

Main Topics: Histology and Embryology

Journal: Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 4, pp.740-747

Document Type: Article

Publication Date: 3/2024

Document Language: English

Document ID (Org No.): 2001302833

pISSN: 1309-4483

Acrylamide

Ferulic acid

testis

rat

Issues

Authors:

Arzu Gezer | Seda Yakut | Nurcan Kılıç Bargutalp | Berrin Tarakcı Gencer

Publisher:

Ondokuz Mayıs University

Main Topics:

Histology and Embryology

Journal:

Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 4, pp.740-747

Document Type:

Article

Publication Date:

3/2024

Document Language:

English

Document ID (Org No.):

2001302833

pISSN:

1309-4483