Detection of Epstein Barr Virus DNA by in Situ Hybridization in Gastric Cancer Patients

Bayan H. Ahmed

Article Details

Detection of Epstein Barr Virus DNA by in Situ Hybridization in Gastric Cancer Patients

Authors:

Bayan H. Ahmed

Publisher:

The International Centre for Advancement of Sciences and Technology

Main Topics:

Medicine

Journal:

International Journal for Sciences and Technology 2012 Vol.7 Issue 2, pp.66-74

Document Type:

Article

Publication Date:

6/2012

Document Language:

English

Document ID (Org No.):

26171

Frequency:

Quarterly

eISSN:

18172509

pISSN:

18162509

Descriptors:

Keywords:

Abstract:

 Epstein Barr virus (EBV) is a member of Herpesviridae families and the well known cause of the worldwide common infectious mononucleosis. An increasing number of studies have suggested causal relationship between (EBV) and primary gastric adenocarcinoma. In this study we investigate the expression of (EBV) in gastric adenocarcinoma using (EBV-DNA) detection kit and we try to correlate the clinical and the pathological parameters with (EBV) expression. Among 30 randomly selected cases of gastric adenocarcinoma, there were 17 male and 13 female with male to female ratio 1.3:1 (EBV) was detected in (26.6%) cases, male to female 1:1. The mean age for the entire group was 55.8 ± 13.39 where as the mean age for patients with EBV-GC was 56 ± 17.7 yrs. (EBV) positive expression was slightly predominant in the distal third of the stomach, more frequent in the intestinal subtype, distributed between grade II and III. Statistical analysis shows no significant correlation regarding all the above parameters. Our conclusion that there is an association between(EBV) infection and gastric cancer.

 Epstein Barr Viurus هو عضو من عائلة ال Herpesvirida وهو معروف عالميا كأحد اسباب تكثر وحيدات النواة في الدم ، أن الدراسات المتزايدة أقترحت علاقة سببية بين EBV والسرطان الغدي المعوي الاولي. في هذه الدراسة قمنا بالتحري عن EBV في السرطان الغدي المعوي باستعمال عدة التحري عن EBV –DNA كما حاولنا ايجاد العلاقة بين وجود EBV والعلامات السريرية والمرضية.
من بين 30 حالة للسرطان الغدي المعوي المختارة عشوائيا كانت هنالك 17 من الذكور و13 من الاناث وبنسبة 1.3: 1 تم تشخيص EBV في (26.6%) حيث كانت نسبة الذكور الى الاناث 1:1. ان المعدل العمري للمجموع الكامل 55.8 ± 13.39 سنة بينما كان معدل اعمار المرضى الحاملين لل EBV في السرطان الغدي المعوي هو56 ± 17.7 سنة.
اظهر التحليل الاحصائي عدم وجود فروقات معنوية بالاعتماد على المقاييس المذكورة اعلاه. ان استنتاجنا هو وجود ارتباط بين الاصابة ب EBV والسرطان المعدي.

Article Details

Detection of Epstein Barr Virus DNA by in Situ Hybridization in Gastric Cancer Patients

Authors:

Bayan H. Ahmed

Publisher:

The International Centre for Advancement of Sciences and Technology

Main Topics:

Medicine

Journal:

International Journal for Sciences and Technology 2012 Vol.7 Issue 2, pp.66-74

Document Type:

Article

Publication Date:

6/2012

Document Language:

English

Document ID (Org No.):

26171

Frequency:

Quarterly

eISSN:

18172509

pISSN:

18162509

Descriptors:

EPSTEIN-BARR VIRUS

CANCER

STOMACH

BLOOD CELLS

DNA

HYBRIDIZATION

PATIENTS

DIAGNOSIS

IRAQ

Epistein Bar virus

DNA

In situ hybridization gastric Ca

Issues

Article Details

Authors: Bayan H. Ahmed

Publisher: The International Centre for Advancement of Sciences and Technology

Main Topics: Medicine

Journal: International Journal for Sciences and Technology 2012 Vol.7 Issue 2, pp.66-74

Document Type: Article

Publication Date: 6/2012

Document Language: English

Document ID (Org No.): 26171

Frequency: Quarterly

eISSN: 18172509

pISSN: 18162509

Descriptors:

Issues

Authors:

Bayan H. Ahmed

Publisher:

The International Centre for Advancement of Sciences and Technology

Main Topics:

Medicine

Journal:

International Journal for Sciences and Technology 2012 Vol.7 Issue 2, pp.66-74

Document Type:

Article

Publication Date:

6/2012

Document Language:

English

Document ID (Org No.):

26171

Frequency:

Quarterly

eISSN:

18172509

pISSN:

18162509