Swelling and Anticancer Drug Uptake Capacity of Chitosan/Hyaluronic Acid/Gelatin Hydrogels

Betül Taşdelen; Ömer Faruk Güder

Article Details

Swelling and Anticancer Drug Uptake Capacity of Chitosan/Hyaluronic Acid/Gelatin Hydrogels

Authors:

Betül Taşdelen | Ömer Faruk Güder

Publisher:

Tekirdag Namik Kemal University

Main Topics:

Biyomedikal Mühendisliğinde Biyomateryaller

Journal:

European Journal of Engineering and Applied Sciences Vol.7 Issue 1, pp.21-26

Document Type:

Article

Publication Date:

7/2024

Document Language:

Turkish

Document ID (Org No.):

2001309671

pISSN:

2651-3412

Keywords:

Abstract:

 Nowadays, the number of patients diagnosed with cancer is increasing day by day. Chemotherapy is an indispensable treatment method in many cancer treatments. Hydrogels have the ability to absorbdesorb water thanks to their cross-links and 3-dimensional network structures. In order to eliminate the disadvantages of chemotherapy applications and to ensure that a sufficient dose of drug is given to the patient, targeted drug release technologies have been developed and hydrogels have come to the fore in this field. Natural polymeric hydrogels are widely used in the medical field. ChitosanCS natural biopolymer has been used in controlled drug release systems for many years due to its unique properties such as high biocompatibility, biodegradability and low toxicity. By using different natural biopolymers with CS, the swelling and drup uptake capacity properties of the hydrogels can be improved. In this article, the swelling and drug uptake capacity of CS, CSHA and CSHAGEL hydrogels in the 5-Fluorouracil 5-FU used as a model drug was evaluated and drug uptake capacities were determined by UV-Vis spectrophotometer. As a result, swelling and drug uptake capacities of CS, CSHA and CSHAGEL hydrogels in anticancer drug solution were investigated. While the 5-FU retention capacity 1.2 mg 5-FUg dry gel increased with the addition of HA to CS, a decrease in 5-FU retention capacity 0.4 mg 5-FUg dry gel was observed with the addition of GEL to CS. All the prepared hydrogels are promising in future for controlled drug delivery sytems in biomedical applications.

 Nowadays, the number of patients diagnosed with cancer is increasing day by day. Chemotherapy is an indispensable treatment method in many cancer treatments. Hydrogels have the ability to absorbdesorb water thanks to their cross-links and 3-dimensional network structures. In order to eliminate the disadvantages of chemotherapy applications and to ensure that a sufficient dose of drug is given to the patient, targeted drug release technologies have been developed and hydrogels have come to the fore in this field. Natural polymeric hydrogels are widely used in the medical field. ChitosanCS natural biopolymer has been used in controlled drug release systems for many years due to its unique properties such as high biocompatibility, biodegradability and low toxicity. By using different natural biopolymers with CS, the swelling and drup uptake capacity properties of the hydrogels can be improved. In this article, the swelling and drug uptake capacity of CS, CSHA and CSHAGEL hydrogels in the 5-Fluorouracil 5-FU used as a model drug was evaluated and drug uptake capacities were determined by UV-Vis spectrophotometer. As a result, swelling and drug uptake capacities of CS, CSHA and CSHAGEL hydrogels in anticancer drug solution were investigated. While the 5-FU retention capacity 1.2 mg 5-FUg dry gel increased with the addition of HA to CS, a decrease in 5-FU retention capacity 0.4 mg 5-FUg dry gel was observed with the addition of GEL to CS. All the prepared hydrogels are promising in future for controlled drug delivery sytems in biomedical applications.

 Nowadays, the number of patients diagnosed with cancer is increasing day by day. Chemotherapy is an indispensable treatment method in many cancer treatments. Hydrogels have the ability to absorbdesorb water thanks to their cross-links and 3-dimensional network structures. In order to eliminate the disadvantages of chemotherapy applications and to ensure that a sufficient dose of drug is given to the patient, targeted drug release technologies have been developed and hydrogels have come to the fore in this field. Natural polymeric hydrogels are widely used in the medical field. ChitosanCS natural biopolymer has been used in controlled drug release systems for many years due to its unique properties such as high biocompatibility, biodegradability and low toxicity. By using different natural biopolymers with CS, the swelling and drup uptake capacity properties of the hydrogels can be improved. In this article, the swelling and drug uptake capacity of CS, CSHA and CSHAGEL hydrogels in the 5-Fluorouracil 5-FU used as a model drug was evaluated and drug uptake capacities were determined by UV-Vis spectrophotometer. As a result, swelling and drug uptake capacities of CS, CSHA and CSHAGEL hydrogels in anticancer drug solution were investigated. While the 5-FU retention capacity 1.2 mg 5-FUg dry gel increased with the addition of HA to CS, a decrease in 5-FU retention capacity 0.4 mg 5-FUg dry gel was observed with the addition of GEL to CS. All the prepared hydrogels are promising in future for controlled drug delivery sytems in biomedical applications.

 Günümüzde kanser teşhisi konulan hasta sayısı her geçen gün artmaktadır. Pek çok kanser tedavisinde kemoterapi vazgeçilmez tedavi yöntemidir. Kemoterapi uygulamalarının dezavantajlarını ortadan kaldırmak ve hastaya yeterli dozda ilaç verilmesinin sağlanması amacıyla hedefe yönelik ilaç salım teknolojileri geliştirilmiş ve hidrojeller bu alanda öne çıkmıştır. Hidrojeller, çapraz bağları ve 3-boyutlu ağ yapıları sayesinde su absorplama ve desorplama yeteneğine sahiptirler. Doğal polimerik hidrojeller tıp alanında yaygın olarak kullanılmaktadır. KitosanCS doğal biyopolimeri, yüksek biyouyumluluk, biyobozunabilirlik ve düşük toksisite gibi benzersiz özellikleri nedeniyle uzun yıllardır kontrollü ilaç salım sistemlerinde kullanılmaktadır. Farklı doğal biyopolimerlerin CS ile sentezlenmesi ile oluşan hidrojellerin şişme ve ilaç tutma kapasitesi özellikleri geliştirilebilir. Bu makalede, CSye hyaluronik asitHA ve jelatinGEL ilave edilmesiyle geliştirilmiş yeni tip CSHAGEL hidrojellerinin model ilaç olarak kullanılan 5-Fluorourasil5-FU antikanser ilacındaki kütlece şişmeleri değerlendirilmiş, UV-Vis spektrofotometre ile 5-FU ilacı tutma kapasiteleri belirlenmiştir. Sonuç olarak, CS, CSHA ve CSHAGEL hidrojellerinin antikanser ilacında şişme davranışı ve ilaç tutma kapasiteleri incelendi. CSye HA eklenmesiyle 5-FU tutma kapasitesi 1.2 mg 5-FUg kuru jel artarken CSye GEL ilave edilmesiyle ise 5-FU tutma kapasitesi 0.4 mg 5-FUg kuru jel azalma gözlenmiştir. Sentezlenen hidrojeller, biyomedikal alanda kontrollü ilaç salım sistemlerinde umut vadetmektedir.

Article Details

Swelling and Anticancer Drug Uptake Capacity of Chitosan/Hyaluronic Acid/Gelatin Hydrogels

Authors:

Betül Taşdelen | Ömer Faruk Güder

Publisher:

Tekirdag Namik Kemal University

Main Topics:

Biyomedikal Mühendisliğinde Biyomateryaller

Journal:

European Journal of Engineering and Applied Sciences Vol.7 Issue 1, pp.21-26

Document Type:

Article

Publication Date:

7/2024

Document Language:

Turkish

Document ID (Org No.):

2001309671

pISSN:

2651-3412

Hydrogel

Hyaluronic acid

Drug retention

Gelatin

Chitosan

5-FUHidrojel

Hyaluronik asit

İlaç Tutma

Jelatin

Kitosan

5-FU

Issues

Article Details

Authors: Betül Taşdelen | Ömer Faruk Güder

Publisher: Tekirdag Namik Kemal University

Main Topics: Biyomedikal Mühendisliğinde Biyomateryaller

Journal: European Journal of Engineering and Applied Sciences Vol.7 Issue 1, pp.21-26

Document Type: Article

Publication Date: 7/2024

Document Language: Turkish

Document ID (Org No.): 2001309671

pISSN: 2651-3412

Issues

Authors:

Betül Taşdelen | Ömer Faruk Güder

Publisher:

Tekirdag Namik Kemal University

Main Topics:

Biyomedikal Mühendisliğinde Biyomateryaller

Journal:

European Journal of Engineering and Applied Sciences Vol.7 Issue 1, pp.21-26

Document Type:

Article

Publication Date:

7/2024

Document Language:

Turkish

Document ID (Org No.):

2001309671

pISSN:

2651-3412