Cryptogenic cirrhosis and Common variable immunodeficiency: an unrecognized relationship

Recep Evcen; Murat Bıyık; Fatih Çölkesen; Filiz Sadi Aykan; Mehmet Kılınç; Mehmet Emin Gerek; Tacettin Akçal; Eray Yıldız; Şevket Arslan

Article Details

Cryptogenic cirrhosis and Common variable immunodeficiency: an unrecognized relationship

Authors:

Recep Evcen | Murat Bıyık | Fatih Çölkesen | Filiz Sadi Aykan | Mehmet Kılınç | Mehmet Emin Gerek | Tacettin Akçal | Eray Yıldız | Şevket Arslan

Publisher:

Prusa Medical Publishing

Main Topics:

Allergy

Journal:

The European Research Journal Vol.11 Issue 2, pp.244-250

Document Type:

Article

Publication Date:

4/2025

Document Language:

English

Document ID (Org No.):

2001341269

pISSN:

2149-3189

Keywords:

Abstract:

 Objective: This study investigates the prevalence of Common Variable Immunodeficiency CVID in patients with cryptogenic cirrhosis. It aims to highlight CVIDs role in liver involvement and raise awareness of its potential as an underlying cause of cryptogenic cirrhosis. Methods: This retrospective cohort study, approved by the ethics committee, included patients diagnosed with cryptogenic cirrhosis at a university hospital. Comprehensive evaluations were performed to exclude other causes of cirrhosis, and patients were screened for CVID based on the European Society for Immunodeficiencies ESID criteria. Results: This study included 30 patients with cryptogenic cirrhosis, among whom 6.7 n2 were diagnosed with CVID. Both CVID patients had low immunoglobulin levels and abnormal immune cell profiles, leading to recurrent infections in one case and suspicion due to low total protein levels in the other. IVIG treatment was initiated for both, and liver biopsy findings in one patient suggested CVID-related liver involvement. Conclusions: Determining the underlying causes of chronic liver diseases is crucial for guiding treatment and follow-up, potentially preventing cirrhosis progression and influencing liver transplantation eligibility. CVID screening in patients with cryptogenic cirrhosis should be considered, with appropriate treatments initiated as needed.

 Objective: This study investigates the prevalence of Common Variable Immunodeficiency CVID in patients with cryptogenic cirrhosis. It aims to highlight CVIDs role in liver involvement and raise awareness of its potential as an underlying cause of cryptogenic cirrhosis. Methods: This retrospective cohort study, approved by the ethics committee, included patients diagnosed with cryptogenic cirrhosis at a university hospital. Comprehensive evaluations were performed to exclude other causes of cirrhosis, and patients were screened for CVID based on the European Society for Immunodeficiencies ESID criteria. Results: This study included 30 patients with cryptogenic cirrhosis, among whom 6.7 n2 were diagnosed with CVID. Both CVID patients had low immunoglobulin levels and abnormal immune cell profiles, leading to recurrent infections in one case and suspicion due to low total protein levels in the other. IVIG treatment was initiated for both, and liver biopsy findings in one patient suggested CVID-related liver involvement. Conclusions: Determining the underlying causes of chronic liver diseases is crucial for guiding treatment and follow-up, potentially preventing cirrhosis progression and influencing liver transplantation eligibility. CVID screening in patients with cryptogenic cirrhosis should be considered, with appropriate treatments initiated as needed.

 Objective: This study investigates the prevalence of Common Variable Immunodeficiency CVID in patients with cryptogenic cirrhosis. It aims to highlight CVIDs role in liver involvement and raise awareness of its potential as an underlying cause of cryptogenic cirrhosis. Methods: This retrospective cohort study, approved by the ethics committee, included patients diagnosed with cryptogenic cirrhosis at a university hospital. Comprehensive evaluations were performed to exclude other causes of cirrhosis, and patients were screened for CVID based on the European Society for Immunodeficiencies ESID criteria. Results: This study included 30 patients with cryptogenic cirrhosis, among whom 6.7 n2 were diagnosed with CVID. Both CVID patients had low immunoglobulin levels and abnormal immune cell profiles, leading to recurrent infections in one case and suspicion due to low total protein levels in the other. IVIG treatment was initiated for both, and liver biopsy findings in one patient suggested CVID-related liver involvement. Conclusions: Determining the underlying causes of chronic liver diseases is crucial for guiding treatment and follow-up, potentially preventing cirrhosis progression and influencing liver transplantation eligibility. CVID screening in patients with cryptogenic cirrhosis should be considered, with appropriate treatments initiated as needed.

 Objective: This study investigates the prevalence of Common Variable Immunodeficiency CVID in patients with cryptogenic cirrhosis. It aims to highlight CVIDs role in liver involvement and raise awareness of its potential as an underlying cause of cryptogenic cirrhosis. Methods: This retrospective cohort study, approved by the ethics committee, included patients diagnosed with cryptogenic cirrhosis at a university hospital. Comprehensive evaluations were performed to exclude other causes of cirrhosis, and patients were screened for CVID based on the European Society for Immunodeficiencies ESID criteria. Results: This study included 30 patients with cryptogenic cirrhosis, among whom 6.7 n2 were diagnosed with CVID. Both CVID patients had low immunoglobulin levels and abnormal immune cell profiles, leading to recurrent infections in one case and suspicion due to low total protein levels in the other. IVIG treatment was initiated for both, and liver biopsy findings in one patient suggested CVID-related liver involvement. Conclusions: Determining the underlying causes of chronic liver diseases is crucial for guiding treatment and follow-up, potentially preventing cirrhosis progression and influencing liver transplantation eligibility. CVID screening in patients with cryptogenic cirrhosis should be considered, with appropriate treatments initiated as needed.

Article Details

Cryptogenic cirrhosis and Common variable immunodeficiency: an unrecognized relationship

Authors:

Recep Evcen | Murat Bıyık | Fatih Çölkesen | Filiz Sadi Aykan | Mehmet Kılınç | Mehmet Emin Gerek | Tacettin Akçal | Eray Yıldız | Şevket Arslan

Publisher:

Prusa Medical Publishing

Main Topics:

Allergy

Journal:

The European Research Journal Vol.11 Issue 2, pp.244-250

Document Type:

Article

Publication Date:

4/2025

Document Language:

English

Document ID (Org No.):

2001341269

pISSN:

2149-3189

Common variable immunodeficiency

cryptogenic cirrhosis

nodular regenerative hyperplasia

Issues

Article Details

Cryptogenic cirrhosis and Common variable immunodeficiency: an unrecognized relationship

Authors: Recep Evcen | Murat Bıyık | Fatih Çölkesen | Filiz Sadi Aykan | Mehmet Kılınç | Mehmet Emin Gerek | Tacettin Akçal | Eray Yıldız | Şevket Arslan

Publisher: Prusa Medical Publishing

Main Topics: Allergy

Journal: The European Research Journal Vol.11 Issue 2, pp.244-250

Document Type: Article

Publication Date: 4/2025

Document Language: English

Document ID (Org No.): 2001341269

pISSN: 2149-3189

Common variable immunodeficiency

cryptogenic cirrhosis

nodular regenerative hyperplasia

Issues

Authors:

Recep Evcen | Murat Bıyık | Fatih Çölkesen | Filiz Sadi Aykan | Mehmet Kılınç | Mehmet Emin Gerek | Tacettin Akçal | Eray Yıldız | Şevket Arslan

Publisher:

Prusa Medical Publishing

Main Topics:

Allergy

Journal:

The European Research Journal Vol.11 Issue 2, pp.244-250

Document Type:

Article

Publication Date:

4/2025

Document Language:

English

Document ID (Org No.):

2001341269

pISSN:

2149-3189