Effect of Growth Hormone on Final Height in Children with Idiopathic Short Stature : A UAE, Eastern Region Experience

Shireen Mreish; Walid Kaplan; Fares Chedid

doi:10.5001/omj.2017.90

Article Details

Effect of Growth Hormone on Final Height in Children with Idiopathic Short Stature : A UAE, Eastern Region Experience

Authors:

Shireen Mreish | Walid Kaplan | Fares Chedid

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2017 Vol.32 Issue 6, pp.467-470

Document Type:

Article

Publication Date:

11/2017

Document Language:

English

Document ID (Org No.):

111082

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2017.90

Descriptors:

Keywords:

Abstract:

 Objectives: The use of growth hormone (GH) in idiopathic short stature (ISS) has been a subject of debate for the past two decades. We sought to assess the effect of GH on final height (FH) in patients with ISS in our region, which has a high consanguinity rate, and compare it to the effect observed in GH deficient (GHD) patients. Methods: We conducted a retrospective chart review from 1 January 2005 to 31 December 2013 for patients with ISS or GHD from the local United Arab Emirates population who received GH treatment and were followed-up regularly in our clinic. The change in height Z-score at 12 months and FH were assessed within each group and between the two groups. Results: Twenty-one patients with ISS and 29 patients with GHD were studied. There was a significant change in height Z-score at 12 months and FH in both groups (p < 0.001). The improvement in the ISS group was comparable to the response seen in GHD patients at 12 months (0.5±0.3 standard deviation score (SDS), and 0.5±0.4 SDS, respectively; p = 0.540). The effect on FH was better in ISS group than the GHD group of all etiologies (1.3±0.6 SDS vs. 0.9±0.7 SDS, respectively; p = 0.050), there was no difference between the ISS and the subgroup of idiopathic GHD (1.3±0.5 SDS and 1.2±0.8 SDS, respectively). Conclusions: In our local population, GH has a positive effect on the short-term growth and FH of children with ISS to the same extent that has been observed in children with idiopathic GH deficiency.

Article Details

Effect of Growth Hormone on Final Height in Children with Idiopathic Short Stature : A UAE, Eastern Region Experience

Authors:

Shireen Mreish | Walid Kaplan | Fares Chedid

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2017 Vol.32 Issue 6, pp.467-470

Document Type:

Article

Publication Date:

11/2017

Document Language:

English

Document ID (Org No.):

111082

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2017.90

Descriptors:

PAEDIATRICS

GROWTH FAILURE

HORMONE DEFICIENCY

DIAGNOSIS

PATIENTS

UNITED ARAB EMIRATES

Idiopathic Short Stature

Growth Hormone

Consanguinity

Growth Hormone Deficiency

Issues

Article Details

Authors: Shireen Mreish | Walid Kaplan | Fares Chedid

Publisher: Oman Medical Specialty Board

Main Topics: Medicine

Journal: Oman Medical Journal 2017 Vol.32 Issue 6, pp.467-470

Document Type: Article

Publication Date: 11/2017

Document Language: English

Document ID (Org No.): 111082

Frequency: Bi-Monthly

eISSN: 20705204

pISSN: 1999768X

DOI: 10.5001/omj.2017.90

Descriptors:

Issues

Authors:

Shireen Mreish | Walid Kaplan | Fares Chedid

Publisher:

Oman Medical Specialty Board

Main Topics:

Medicine

Journal:

Oman Medical Journal 2017 Vol.32 Issue 6, pp.467-470

Document Type:

Article

Publication Date:

11/2017

Document Language:

English

Document ID (Org No.):

111082

Frequency:

Bi-Monthly

eISSN:

20705204

pISSN:

1999768X

DOI:

10.5001/omj.2017.90