The effect of endobronchial coil treatment (EBCT) on hemorheological parameters and oxidative stress: a pilot study

Erhan Ugurlu; Emine Kılıç Toprak; Nazlı Çetin; Özgen Kılıç Erkek; Nilüfer Yiğit; Hilmiye Pakyürek; Göksel Altınışık Ergur; Z. Melek Küçükatay

Article Details

The effect of endobronchial coil treatment (EBCT) on hemorheological parameters and oxidative stress: a pilot study

Authors:

Erhan Ugurlu | Emine Kılıç Toprak | Nazlı Çetin | Özgen Kılıç Erkek | Nilüfer Yiğit | Hilmiye Pakyürek | Göksel Altınışık Ergur | Z. Melek Küçükatay

Publisher:

Pamukkale University

Main Topics:

Göğüs Hastalıkları

Journal:

Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.137-148

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001318846

pISSN:

1308-0865

Keywords:

Abstract:

 Purpose: Chronic Obstructive Pulmonary Disease COPD is a common, preventable, curable disease characterized by persistent airflow limitation, respiratory symptoms due to airway andor alveolar abnormalities caused by severe exposure to harmful particles, gases. During the endobronchial coil treatment EBCT process, the volume of the lung parenchyma is reduced by shrinking the elastic recoil. Although there are studies showing worsening of hemorheological parameters in COPD exacerbations, no study investigated whether hemorheological parameters are improved after coil. The aim of this study was to assess the effects of coil therapy on erythrocyte deformability, whole blood viscosity WBV measured at autologous, standard 40 hematocrit and plasma viscosity PV in COPD patients. Material and methods: Venous blood samples were taken once from the healthy control group n17 and before and 1 month after the treatment from the COPD patients who had been indicated for coil according to GOLD guidelines n20. To assess erythrocyte deformability, shear-dependent erythrocyte elongation was measured at 0.3-3.0 Pa by an ektacytometer LORCA, while WBV, PV were measured using a rotational viscometer. Results: Erythrocyte deformability measured at shear stresses between 0.3-5.33 Pa were found to be higher following treatment compared to pre-coil values. EBCT did not have a statistically significant effect on WBV measured at autologous, 40 hematocrit, PV and oxidative stress indices. Conclusion: Increased erythrocyte deformability determined following EBCT at the shear stresses observed at the pulmonary level is a favourable finding, showing that the procedure may positively affect the hemodynamics of COPD patients as well as causing clinical improvement.

 Purpose: Chronic Obstructive Pulmonary Disease COPD is a common, preventable, curable disease characterized by persistent airflow limitation, respiratory symptoms due to airway andor alveolar abnormalities caused by severe exposure to harmful particles, gases. During the endobronchial coil treatment EBCT process, the volume of the lung parenchyma is reduced by shrinking the elastic recoil. Although there are studies showing worsening of hemorheological parameters in COPD exacerbations, no study investigated whether hemorheological parameters are improved after coil. The aim of this study was to assess the effects of coil therapy on erythrocyte deformability, whole blood viscosity WBV measured at autologous, standard 40 hematocrit and plasma viscosity PV in COPD patients. Material and methods: Venous blood samples were taken once from the healthy control group n17 and before and 1 month after the treatment from the COPD patients who had been indicated for coil according to GOLD guidelines n20. To assess erythrocyte deformability, shear-dependent erythrocyte elongation was measured at 0.3-3.0 Pa by an ektacytometer LORCA, while WBV, PV were measured using a rotational viscometer. Results: Erythrocyte deformability measured at shear stresses between 0.3-5.33 Pa were found to be higher following treatment compared to pre-coil values. EBCT did not have a statistically significant effect on WBV measured at autologous, 40 hematocrit, PV and oxidative stress indices. Conclusion: Increased erythrocyte deformability determined following EBCT at the shear stresses observed at the pulmonary level is a favourable finding, showing that the procedure may positively affect the hemodynamics of COPD patients as well as causing clinical improvement.

 Purpose: Chronic Obstructive Pulmonary Disease COPD is a common, preventable, curable disease characterized by persistent airflow limitation, respiratory symptoms due to airway andor alveolar abnormalities caused by severe exposure to harmful particles, gases. During the endobronchial coil treatment EBCT process, the volume of the lung parenchyma is reduced by shrinking the elastic recoil. Although there are studies showing worsening of hemorheological parameters in COPD exacerbations, no study investigated whether hemorheological parameters are improved after coil. The aim of this study was to assess the effects of coil therapy on erythrocyte deformability, whole blood viscosity WBV measured at autologous, standard 40 hematocrit and plasma viscosity PV in COPD patients. Material and methods: Venous blood samples were taken once from the healthy control group n17 and before and 1 month after the treatment from the COPD patients who had been indicated for coil according to GOLD guidelines n20. To assess erythrocyte deformability, shear-dependent erythrocyte elongation was measured at 0.3-3.0 Pa by an ektacytometer LORCA, while WBV, PV were measured using a rotational viscometer. Results: Erythrocyte deformability measured at shear stresses between 0.3-5.33 Pa were found to be higher following treatment compared to pre-coil values. EBCT did not have a statistically significant effect on WBV measured at autologous, 40 hematocrit, PV and oxidative stress indices. Conclusion: Increased erythrocyte deformability determined following EBCT at the shear stresses observed at the pulmonary level is a favourable finding, showing that the procedure may positively affect the hemodynamics of COPD patients as well as causing clinical improvement.

 Amaç: Kronik Obstrüktif Akciğer Hastalığı KOAH, zararlı partiküllere, gazlara şiddetli maruziyetin neden olduğu hava yolu veveya alveolar anormalliklere bağlı kalıcı hava akımı kısıtlılığı, solunum semptomları ile karakterize yaygın, önlenebilir, tedavi edilebilir bir hastalıktır. Endobronşiyal koil tedavisi EBCT işlemi sırasında elastik geri tepme küçültülerek akciğer parankiminin hacmi azaltılır. KOAH alevlenmelerinde hemoreolojik parametrelerin kötüleştiğini gösteren çalışmalar olmasına rağmen, koil sonrası hemoreolojik parametrelerin iyileşip iyileşmediğini araştıran bir çalışma yoktur. Bu çalışmanın amacı, KOAH hastalarında koil tedavisinin eritrosit deformabilitesi, otolog, standart 40 hematokritte ölçülen tam kan viskozitesi WBV ve plazma viskozitesi PV üzerindeki etkilerini değerlendirmektir. Gereç ve yöntem: Sağlıklı kontrol grubundan n17 ve GOLD yönergelerine göre coil için endikasyon konulmuş olan KOAH hastalarından n20 tedaviden önce ve 1 ay sonra venöz kan örnekleri alındı. Eritrosit deformabilitesini değerlendirmek için, kaymaya bağlı eritrosit uzaması 0,3-3,0 Pada bir ektasitometre LORCA ile ölçülürken, WBV, PV rotasyonel bir viskozimetre kullanılarak ölçüldü. Bulgular: Eritrosit deformabilitesi 0,3-5,33 Pa arasındaki kayma streslerinde ölçülmüş ve tedavi sonrasında coil öncesi değerlere kıyasla daha yüksek bulunmuştur. EBCTnin otolog, 40 hematokrit, PV ve oksidatif stres indekslerinde ölçülen WBV üzerinde istatistiksel olarak anlamlı bir etkisi olmamıştır. Sonuç: EBCT sonrasında pulmoner düzeyde gözlenen kayma gerilimlerinde belirlenen artmış eritrosit deformabilitesi, işlemin KOAH hastalarının hemodinamiğini olumlu yönde etkileyebileceğini ve klinik iyileşmeye neden olabileceğini gösteren olumlu bir bulgudur.

Article Details

The effect of endobronchial coil treatment (EBCT) on hemorheological parameters and oxidative stress: a pilot study

Authors:

Erhan Ugurlu | Emine Kılıç Toprak | Nazlı Çetin | Özgen Kılıç Erkek | Nilüfer Yiğit | Hilmiye Pakyürek | Göksel Altınışık Ergur | Z. Melek Küçükatay

Publisher:

Pamukkale University

Main Topics:

Göğüs Hastalıkları

Journal:

Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.137-148

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001318846

pISSN:

1308-0865

Chronic obstructive pulmonary disease

endobronchial coil therapy

erythrocyte deformability

hemorheology

oxidative stressKronik obstrüktif akciğer hastalığı

endobronşiyal koil tedavisi

eritrosit deformabilitesi

hemoreoloji

oksidatif stress

Issues

Article Details

Authors: Erhan Ugurlu | Emine Kılıç Toprak | Nazlı Çetin | Özgen Kılıç Erkek | Nilüfer Yiğit | Hilmiye Pakyürek | Göksel Altınışık Ergur | Z. Melek Küçükatay

Publisher: Pamukkale University

Main Topics: Göğüs Hastalıkları

Journal: Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.137-148

Document Type: Article

Publication Date: 1/2025

Document Language: English

Document ID (Org No.): 2001318846

pISSN: 1308-0865

Issues

Authors:

Erhan Ugurlu | Emine Kılıç Toprak | Nazlı Çetin | Özgen Kılıç Erkek | Nilüfer Yiğit | Hilmiye Pakyürek | Göksel Altınışık Ergur | Z. Melek Küçükatay

Publisher:

Pamukkale University

Main Topics:

Göğüs Hastalıkları

Journal:

Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.137-148

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001318846

pISSN:

1308-0865