Investigating the predictive role of serum amyloid A and its association with immunological and coagulation biomarkers in recurrent pregnancy loss

Ghada Barakat; Mahmoud Thabet; Kawkab Ali Hasan; Dalia Moemen; Ismail A. Elhefnawy; Ahmed Ragab; Dalia Mahmoud Abdelmonem Elsherbini; Mohamed El-Sherbiny; Nagwan Ahmed Bahgat; Maged Ragheb Elshamy; Rayan G. Albarakati; Baisakhi Kar; Sara Izzeldin Hassan; Spogmai Arif; Saima Reshi; Abida Ikram; Rebecamma Ommen; Nayla Jamal Bushaqer; Mahmoud Mohamed Abdel-Razik; Waleed Eldars

Article Details

Investigating the predictive role of serum amyloid A and its association with immunological and coagulation biomarkers in recurrent pregnancy loss

Authors:

Ghada Barakat | Mahmoud Thabet | Kawkab Ali Hasan | Dalia Moemen | Ismail A. Elhefnawy | Ahmed Ragab | Dalia Mahmoud Abdelmonem Elsherbini | Mohamed El-Sherbiny | Nagwan Ahmed Bahgat | Maged Ragheb Elshamy | Rayan G. Albarakati | Baisakhi Kar | Sara Izzeldin Hassan | Spogmai Arif | Saima Reshi | Abida Ikram | Rebecamma Ommen | Nayla Jamal Bushaqer | Mahmoud Mohamed Abdel-Razik | Waleed Eldars

Publisher:

Libyan Journal of Medicine

Journal:

Libyan Journal of Medicine Vol.20 Issue 1, pp.0-0

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001392835

pISSN:

1819-6357

Keywords:

Abstract:

 To evaluate the predictive role of serum amyloid A (SAA) levels and their association with antiphospholipid antibodies (APA) and coagulation markers such as lupus anticoagulants (LA), anticardiolipin (ACA), protein C (PC) deficiency, protein S (PS) deficiency, and antithrombin III (ATIII) deficiency in recurrent pregnancy loss (RPL). This prospective case-control study comprised two groups: the study group (n = 88) included women with recurrent pregnancy loss at Mansoura University Hospital between January 2019 and December 2020, and the control group (n = 52) included women without obstetric or medical complications. Demographic, clinical, and laboratory data, including serum samples collected at 10 weeks of gestation, were collected from all participants. The study measured SAA levels, lupus anticoagulants, anti-cardiolipin, protein C, protein S, and antithrombin III levels. The SAA level was significantly elevated in the recurrent pregnancy loss group compared to that in the control group. Lupus anticoagulant positive, anti-cardiolipin positive Immunoglobulin M (IgM), and deficiencies in protein C, protein S, and antithrombin III were significantly observed in patients with RPL (p < 0.05). The SAA levels were significantly elevated in both LA-positive and ACA-positive IgM patients. The receiver operating characteristic (ROC) curve analysis demonstrated that at SAA > 24.8 for the prediction of recurrent pregnancy loss, sensitivity was 98.86%, and specificity was 92.31%. Positive and negative predictive values were 95.6% and 98.0%, respectively. The area under the curve = 0.971 (0.927–0.992). SAA is associated with recurrent pregnancy loss and may therefore serve as a potential predictor of this condition. The observed elevation in SAA levels could be primary or secondary to the inflammatory response that promotes thrombotic activity in RPL patients at risk of APA, Protein S, Protein C, and ATIII deficiencies. Implementing SAA screening during pregnancy may facilitate the identification of individuals who could potentially benefit from novel treatment strategies.

Article Details

Investigating the predictive role of serum amyloid A and its association with immunological and coagulation biomarkers in recurrent pregnancy loss

Publisher:

Libyan Journal of Medicine

Journal:

Libyan Journal of Medicine Vol.20 Issue 1, pp.0-0

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001392835

pISSN:

1819-6357

Antiphospholipid syndrome

recurrent early pregnancy loss

serum amyloid A protein

protein C

protein S

Issues

Article Details

Investigating the predictive role of serum amyloid A and its association with immunological and coagulation biomarkers in recurrent pregnancy loss

Publisher: Libyan Journal of Medicine

Journal: Libyan Journal of Medicine Vol.20 Issue 1, pp.0-0

Document Type: Article

Publication Date: 1/2025

Document Language: English

Document ID (Org No.): 2001392835

pISSN: 1819-6357

Antiphospholipid syndrome

recurrent early pregnancy loss

serum amyloid A protein

protein C

protein S

Issues

Publisher:

Libyan Journal of Medicine

Journal:

Libyan Journal of Medicine Vol.20 Issue 1, pp.0-0

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001392835

pISSN:

1819-6357