Endothelial Function and Flow-Mediated Dilation of Brachial Artery in Pre-Eclampsia : Color Doppler Ultrasound Study

Negin Rezavand; Firoozeh Veisi; Maryam Zangeneh; Seyede Sepide Naghibi; Seyed Mohammad Saleh Seyedzadeh; Mansour Rezaei

doi:10.5742/MEWFM.2017.93138

Article Details

Endothelial Function and Flow-Mediated Dilation of Brachial Artery in Pre-Eclampsia : Color Doppler Ultrasound Study

Authors:

Negin Rezavand | Firoozeh Veisi | Maryam Zangeneh | Seyede Sepide Naghibi | Seyed Mohammad Saleh Seyedzadeh | Mansour Rezaei

Publisher:

medi+WORLD International

Main Topics:

Medicine

Journal:

World Family Medicine Journal: Incorporating the Middle East Journal of Family Medicine 2017 Vol.15 Issue 10, pp.56-62

Document Type:

Article

Publication Date:

12/2017

Document Language:

English

Document ID (Org No.):

113220

Frequency:

Monthly

eISSN:

18390196

pISSN:

18390188

DOI:

10.5742/MEWFM.2017.93138

Descriptors:

Keywords:

Abstract:

 Background: Endothelial dysfunction plays animportant role in pre-eclampsia pathogenesis. Thiscan be assessed non-invasively by measuringarterial flow-mediated dilation (FMD).Objective: To compare FMD of the brachial arteryand endothelial function between healthy mothersand those who were diagnosed with pre-eclampsia.Methods: Three groups of pregnant women 20 to35 years old in gestational weeks 32 to 40 wererecruited including healthy subjects (60 cases),mild pre-eclampsia (60 cases), and severe preeclampsia(60 cases). FMD of the brachial arterywas measured by color Doppler ultrasound andcompared between the groups.Results: Mean FMD values were 9.72%, 5.07%,and4.33% respectively in the healthy group, mild preeclampsia,and severe pre-eclampsia (P< 0.001).According to logistic regression analysis, FMD(adjusted R2 = 25%), RI (adjusted R2 = 17.5%),PI (adjusted R2 = 29.3%), intima-media thickness(adjusted R2 = 43.3%) (P< 0.001) and BMI value(adjusted R2 = 10.3%, P= 0.006) were found tobe significant predictors of pre-eclampsia. However,maternal age (adjusted R2 = 1.4%, P= 0.39),gestational age (adjusted R2 = 0.1%, P= 0.98), andparity (adjusted R2 = 5.5%, P= 0.83) were notfound as significant predictors of pre-eclampsia.With increasing value of FMD of the brachial arterythe likelihood of pre-eclampsia decreased. Withincreasing value of intima-media thickness, PI,and RI, the likelihood of pre-eclampsia increased.Brachial artery FMD had sensitivity, specificity,PPV, and NPV values of respectively 70%, 76.7%,85.7%, and 56.1% to predict pre-eclampsia.Conclusion: Color Doppler ultrasound parametersespecially FMD of the brachial artery is a usefulnon-diagnostic method to predict pre-eclampsia inthe third trimester.

Article Details

Endothelial Function and Flow-Mediated Dilation of Brachial Artery in Pre-Eclampsia : Color Doppler Ultrasound Study

Authors:

Negin Rezavand | Firoozeh Veisi | Maryam Zangeneh | Seyede Sepide Naghibi | Seyed Mohammad Saleh Seyedzadeh | Mansour Rezaei

Publisher:

medi+WORLD International

Main Topics:

Medicine

Journal:

World Family Medicine Journal: Incorporating the Middle East Journal of Family Medicine 2017 Vol.15 Issue 10, pp.56-62

Document Type:

Article

Publication Date:

12/2017

Document Language:

English

Document ID (Org No.):

113220

Frequency:

Monthly

eISSN:

18390196

pISSN:

18390188

DOI:

10.5742/MEWFM.2017.93138

Descriptors:

ENDOTHELIAL CELLS

PREGNANCY TOXAEMIA

DILATATION TECHNIQUE (MEDICINE)

ARTERIES

COLOUR DOPPLER IMAGING

ULTRASOUND

OBSTETRICS

GYNECOLOGY

Pregnancy

Pre-Eclampsia

Doppler Ultrasound

Endothelium

Flow-Mediated Dilatation

Issues

Article Details

Authors: Negin Rezavand | Firoozeh Veisi | Maryam Zangeneh | Seyede Sepide Naghibi | Seyed Mohammad Saleh Seyedzadeh | Mansour Rezaei

Publisher: medi+WORLD International

Main Topics: Medicine

Journal: World Family Medicine Journal: Incorporating the Middle East Journal of Family Medicine 2017 Vol.15 Issue 10, pp.56-62

Document Type: Article

Publication Date: 12/2017

Document Language: English

Document ID (Org No.): 113220

Frequency: Monthly

eISSN: 18390196

pISSN: 18390188

DOI: 10.5742/MEWFM.2017.93138

Descriptors:

Issues

Authors:

Negin Rezavand | Firoozeh Veisi | Maryam Zangeneh | Seyede Sepide Naghibi | Seyed Mohammad Saleh Seyedzadeh | Mansour Rezaei

Publisher:

medi+WORLD International

Main Topics:

Medicine

Journal:

World Family Medicine Journal: Incorporating the Middle East Journal of Family Medicine 2017 Vol.15 Issue 10, pp.56-62

Document Type:

Article

Publication Date:

12/2017

Document Language:

English

Document ID (Org No.):

113220

Frequency:

Monthly

eISSN:

18390196

pISSN:

18390188

DOI:

10.5742/MEWFM.2017.93138