The Oxidative Stress And Antioxidant Status Childhood With İmmune Thrombocytopenic Purpura

Fatma İlknur VAROL; Saadet AKARSU; Bilal ÜSTÜNDAĞ

Article Details

The Oxidative Stress And Antioxidant Status Childhood With İmmune Thrombocytopenic Purpura

Authors:

Fatma İlknur VAROL | Saadet AKARSU | Bilal ÜSTÜNDAĞ

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Promotion of health

Journal:

Pediatric Practice and Research 2019 Vol.7 Issue Ek, pp.342-347

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000584797

Frequency:

Tri-annual

pISSN:

2147-6470

Abstract:

 

The most common cause of acute onset thrombocytopenia in a healthy child is acute immune thrombocytopenic purpura (ITP). Thrombocytopenia is defined as a platelet count below 150x109 / L (1). Immune thrombocytopenic purpura is an autoimmune disease characterized by immune-mediated platelet destruction in the reticuloendothelial system (RES) (2). Other mechanisms that have been suggested to be responsible include impaired platelet production (3), complement-dependent mechanism thrombolysis (4), and antibody-dependent oxidant product hydrogen peroxide causing cellular damage (5).
Approximately 75-80% of the clinical cases of immune thrombocytopenic purpura have been classifiied as acute (self-limiting within six months) and 20-25% as chronic (lasting more than six months) (6)
The aim of the treatment is to inhibit the development of antibodies against platelets by suppressing the immune system and stop the breakdown of platelets in the spleen. Corticosteroids, intravenous immunoglobulin (IVIG), anti-D immunoglobulin and rituximab can be used in the treatment (7). High dose MP or IVIG is preferred as the initial treatment for childhood ITP. Since there is no difference in success rates in treatment, the choice is made on the basis of costs and side effects.
Oxidative damage plays a role in the pathogenesis of autoimmune diseases. Oxidative stress and free radicals have been suggested to be responsible for the pathogenesis and prognosis of ITP. Increased lipid peroxidation and decreased antioxidant capacity in ITP may play a significant role on antibodies bound to membrane lipids and platelet destruction (8).
In the literature, there is little information about oxidative stress and antioxidant defense mechanism in ITP (8). The aim of this study is to investigate the effects of oxidative stress level and different treatment options on antioxidant capacity in acute and chronic ITP and to show that whether the disease would be acute or chronic type can be predicted and the most appropriate choice of treatment can be defined by depending on the oxidative stress index (OSI) obtained during the diagnosis phase.

Article Details

The Oxidative Stress And Antioxidant Status Childhood With İmmune Thrombocytopenic Purpura

Authors: Fatma İlknur VAROL | Saadet AKARSU | Bilal ÜSTÜNDAĞ

Publisher: MediHealth Academy Yayıncılık

Main Topics: Promotion of health

Journal: Pediatric Practice and Research 2019 Vol.7 Issue Ek, pp.342-347

Document Type: Article

Publication Date: 12/2019

Document Language: English

Document ID (Org No.): 2000584797

Frequency: Tri-annual

pISSN: 2147-6470

Issues

Authors:

Fatma İlknur VAROL | Saadet AKARSU | Bilal ÜSTÜNDAĞ

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Promotion of health

Journal:

Pediatric Practice and Research 2019 Vol.7 Issue Ek, pp.342-347

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000584797

Frequency:

Tri-annual

pISSN:

2147-6470