Factors associated with frequency and severity of COVID-19 in patients with axial spondyloarthritis

Mete Pekdiker; Mete Kara; Emrah Koç; Gezmiş Kimyon

Article Details

Factors associated with frequency and severity of COVID-19 in patients with axial spondyloarthritis

Authors:

Mete Pekdiker | Mete Kara | Emrah Koç | Gezmiş Kimyon

Publisher:

Pamukkale University

Main Topics:

Romatoloji ve Artrit

Journal:

Pamukkale Tıp Dergisi Vol.16 Issue 3, pp.404-411

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001282761

pISSN:

1308-0865

Keywords:

Abstract:

 Purpose: The severe course of COVID-19 in individuals with chronic diseases has led to concerns in managing rheumatic diseases during the pandemic; therefore, we aimed to define the factors associated with the frequency and severity of COVID-19 in patients with axial spondyloarthritis axSpa in this study. Materials and methods: Patients with axSpa who were followed up in three tertiary hospitals and used their treatment regularly for at least six months were included. We assessed the relationship between axSpa-associated variables such as disease duration time, radiological severity, treatment and COVID-19 outcomes. Results: A total of 833 patients with a mean disease duration of 109 months were analyzed; 64.5 of them had ankylosing spondylitis, 35.5 had non-radiographic axSpa, and 59.4 of patients were treated with a biologic agent. The frequency of COVID-19 was 23 n:192; only five patients 0.5 had a history of intensive care unit. Advanced age, hypertension HT, and diabetes mellitus DM were found to be significantly more common in those with involvement in high-resolution computed tomography HRCT p:0.02, p:0.01, and p0.001. In hospitalized individuals, female gender, HT, DM, and disease lasting longer than 10 years were significantly higher p:0.03, p:0.011, p0.001, and p:0.014. Only DM was found as an independent risk factor for both pulmonary involvement in HRCT p:0.029 and hospitalization p:0.001. Conclusion: We conducted our study with a homogenous study population and our results suggested that biological agents did not affect poor COVID-19 outcomes; only DM was associated with a more severe COVID-19 course in patients with axSpa.

 Purpose: The severe course of COVID-19 in individuals with chronic diseases has led to concerns in managing rheumatic diseases during the pandemic; therefore, we aimed to define the factors associated with the frequency and severity of COVID-19 in patients with axial spondyloarthritis axSpa in this study. Materials and methods: Patients with axSpa who were followed up in three tertiary hospitals and used their treatment regularly for at least six months were included. We assessed the relationship between axSpa-associated variables such as disease duration time, radiological severity, treatment and COVID-19 outcomes. Results: A total of 833 patients with a mean disease duration of 109 months were analyzed; 64.5 of them had ankylosing spondylitis, 35.5 had non-radiographic axSpa, and 59.4 of patients were treated with a biologic agent. The frequency of COVID-19 was 23 n:192; only five patients 0.5 had a history of intensive care unit. Advanced age, hypertension HT, and diabetes mellitus DM were found to be significantly more common in those with involvement in high-resolution computed tomography HRCT p:0.02, p:0.01, and p0.001. In hospitalized individuals, female gender, HT, DM, and disease lasting longer than 10 years were significantly higher p:0.03, p:0.011, p0.001, and p:0.014. Only DM was found as an independent risk factor for both pulmonary involvement in HRCT p:0.029 and hospitalization p:0.001. Conclusion: We conducted our study with a homogenous study population and our results suggested that biological agents did not affect poor COVID-19 outcomes; only DM was associated with a more severe COVID-19 course in patients with axSpa.

 Purpose: The severe course of COVID-19 in individuals with chronic diseases has led to concerns in managing rheumatic diseases during the pandemic; therefore, we aimed to define the factors associated with the frequency and severity of COVID-19 in patients with axial spondyloarthritis axSpa in this study. Materials and methods: Patients with axSpa who were followed up in three tertiary hospitals and used their treatment regularly for at least six months were included. We assessed the relationship between axSpa-associated variables such as disease duration time, radiological severity, treatment and COVID-19 outcomes. Results: A total of 833 patients with a mean disease duration of 109 months were analyzed; 64.5 of them had ankylosing spondylitis, 35.5 had non-radiographic axSpa, and 59.4 of patients were treated with a biologic agent. The frequency of COVID-19 was 23 n:192; only five patients 0.5 had a history of intensive care unit. Advanced age, hypertension HT, and diabetes mellitus DM were found to be significantly more common in those with involvement in high-resolution computed tomography HRCT p:0.02, p:0.01, and p0.001. In hospitalized individuals, female gender, HT, DM, and disease lasting longer than 10 years were significantly higher p:0.03, p:0.011, p0.001, and p:0.014. Only DM was found as an independent risk factor for both pulmonary involvement in HRCT p:0.029 and hospitalization p:0.001. Conclusion: We conducted our study with a homogenous study population and our results suggested that biological agents did not affect poor COVID-19 outcomes; only DM was associated with a more severe COVID-19 course in patients with axSpa.

 Amaç: Kronik hastalığa sahip bireylerde COVİD-19un ağır seyri romatolojik hastalıkların tedavisinde endişeye yol açmıştır. Bu yüzden çalışmamızda aksiyel spondiloartritli aSpa hastalarda COVİD-19 sıklığı ve şiddeti ile ilişkili faktörleri tanımlamayı amaçladık. Gereç ve yöntem: Üç tersiyer merkezde izlenen ve en az altı aydır tedavilerini düzenli kullanan aSpalı hastalar çalışmaya dahil edildi. Hastalık süresi, radyolojik şiddet ve tedavi gibi aSpa ilişkili değişkenler ile COVİD-19 sonuçları arasındaki ilişkiyi değerlendirdik. Bulgular: Ortalama hastalık süresi 109 ay olan toplam 833 hasta analiz edildi; 64,5inde ankilozan spondilit ve 35,5inde non-radyografik aSpa tanısı mevcutken hastaların 59,4ü biyolojik ajanlarla tedavi edilmekteydi. Çalışma grubumuzda COVİD-19 sıklığı 23 n:192 olup sadece beş olguda 0,5 yoğun bakım ünitesi öyküsü vardı. İleri yaş, hipertansiyon HT ve diabetes mellitus DM yüksek çözünürlüklü bilgisayarlı tomografisinde YÇBT tutulum olan hastalarda anlamlı olarak daha fazlaydı p:0,02, p:0,01 ve p0,001. Hastaneye yatış gerektiren hastalarda ise ileri yaş, HT, DM ve 10 yıldan uzun hastalık süresi anlamlı olarak daha fazlaydı p:0,03, p:0,011, p0,001 ve p:0,014. Çok değişkenli regresyon analizinde sadece DM hem YÇBTde akciğer tutulumu p:0,029 hem de hospitalizasyon p:0,001 için bağımsız bir risk faktörü olarak bulundu. Sonuç: Homojen bir hasta grubu ile yaptığımız çalışmamızın sonuçları biyolojik ajanların COVİD-19 ilişkili kötü sonuçlar üzerine etkisini olmadığını göstermiştir; çalışmamızda sadece DM, aSpalı hastalarda daha ciddi COVİD-19 sonuçları ile ilişkiliydi.

Article Details

Factors associated with frequency and severity of COVID-19 in patients with axial spondyloarthritis

Authors:

Mete Pekdiker | Mete Kara | Emrah Koç | Gezmiş Kimyon

Publisher:

Pamukkale University

Main Topics:

Romatoloji ve Artrit

Journal:

Pamukkale Tıp Dergisi Vol.16 Issue 3, pp.404-411

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001282761

pISSN:

1308-0865

COVID-19

axial spondyloarthritis

ankylosing spondylitis

non-radiographic axial spondyloarthritis

diabetes mellitus

COVID-19

aksiyel spondiloartrit

ankilozan spondilit

radyografik olmayan aksiyel spondiloartrit

şeker hastalığı

Issues

Article Details

Authors: Mete Pekdiker | Mete Kara | Emrah Koç | Gezmiş Kimyon

Publisher: Pamukkale University

Main Topics: Romatoloji ve Artrit

Journal: Pamukkale Tıp Dergisi Vol.16 Issue 3, pp.404-411

Document Type: Article

Publication Date: 1/2023

Document Language: English

Document ID (Org No.): 2001282761

pISSN: 1308-0865

Issues

Authors:

Mete Pekdiker | Mete Kara | Emrah Koç | Gezmiş Kimyon

Publisher:

Pamukkale University

Main Topics:

Romatoloji ve Artrit

Journal:

Pamukkale Tıp Dergisi Vol.16 Issue 3, pp.404-411

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001282761

pISSN:

1308-0865