Effects of Salvia Tomentosa Ointment on Dermal Wound Healing in a Rabbit Model

Mehmet Mustafa Demir; Volkan İpek; Hidayet Tutun; Harun Çınar; Leyla Elif Özgü Ayözger

Article Details

Effects of Salvia Tomentosa Ointment on Dermal Wound Healing in a Rabbit Model

Authors:

Mehmet Mustafa Demir | Volkan İpek | Hidayet Tutun | Harun Çınar | Leyla Elif Özgü Ayözger

Publisher:

Bursa Uludağ University

Main Topics:

Veterinary Sciences (Other)

Journal:

Journal of Research in Veterinary Medicine Vol.42 Issue 2, pp.54-64

Document Type:

Article

Publication Date:

12/2023

Document Language:

English

Document ID (Org No.):

2001308983

pISSN:

2667-6745

Keywords:

Abstract:

 This study aimed to evaluate the wound healing activity of an ointment containing the hydroethanolic extract of Salvia Tomentosa S. tomentosa in a dermal wound model using rabbits. Ointments with concentrations of 2.5 wv and 5 wv were prepared using the hydroethanolic extracts of S. tomentosa. An in vivo excisional wound model was embloyed with New Zealand rabbits n  35 to assess the wound healing activity of these ointments. Rabbits were randomly divided into five experimental groups: negative received no treatment, vehicle received only the ointment vehicle, positive control treated with Fitokrem, and those treated with 2.5 wv and 5 wv S. tomentosa ointments. Wound diameters were measured using calipers on the 4th, 8th, and 14th days, and histopathological examinations were conducted on the 3rd, 7th, and 14th days of treatment. The total phenolic content of the S. tomentosa hydroethanolic extract was determined to be 61.52  2.33 μg of Gallic Acid Equivalents per mg of dry plant material. The total phenolic content and 2,2-diphenyl-1-picrylhydrazyl DPPH scavenging activity of the hydroethanolic extract of Salvia tomentosa were determined spectrophotometrically. In terms of wound closure, both 2.5 and 5 S. tomentosa ointments demonstrated wound healing activity comparable to that of Fitokrem. In conclusion, S. tomentosa exibits a positive effect on dermal wound healing in rabbits.

 This study aimed to evaluate the wound healing activity of an ointment containing the hydroethanolic extract of Salvia Tomentosa S. tomentosa in a dermal wound model using rabbits. Ointments with concentrations of 2.5 wv and 5 wv were prepared using the hydroethanolic extracts of S. tomentosa. An in vivo excisional wound model was embloyed with New Zealand rabbits n  35 to assess the wound healing activity of these ointments. Rabbits were randomly divided into five experimental groups: negative received no treatment, vehicle received only the ointment vehicle, positive control treated with Fitokrem, and those treated with 2.5 wv and 5 wv S. tomentosa ointments. Wound diameters were measured using calipers on the 4th, 8th, and 14th days, and histopathological examinations were conducted on the 3rd, 7th, and 14th days of treatment. The total phenolic content of the S. tomentosa hydroethanolic extract was determined to be 61.52  2.33 μg of Gallic Acid Equivalents per mg of dry plant material. The total phenolic content and 2,2-diphenyl-1-picrylhydrazyl DPPH scavenging activity of the hydroethanolic extract of Salvia tomentosa were determined spectrophotometrically. In terms of wound closure, both 2.5 and 5 S. tomentosa ointments demonstrated wound healing activity comparable to that of Fitokrem. In conclusion, S. tomentosa exibits a positive effect on dermal wound healing in rabbits.

 This study aimed to evaluate the wound healing activity of an ointment containing the hydroethanolic extract of Salvia Tomentosa S. tomentosa in a dermal wound model using rabbits. Ointments with concentrations of 2.5 wv and 5 wv were prepared using the hydroethanolic extracts of S. tomentosa. An in vivo excisional wound model was embloyed with New Zealand rabbits n  35 to assess the wound healing activity of these ointments. Rabbits were randomly divided into five experimental groups: negative received no treatment, vehicle received only the ointment vehicle, positive control treated with Fitokrem, and those treated with 2.5 wv and 5 wv S. tomentosa ointments. Wound diameters were measured using calipers on the 4th, 8th, and 14th days, and histopathological examinations were conducted on the 3rd, 7th, and 14th days of treatment. The total phenolic content of the S. tomentosa hydroethanolic extract was determined to be 61.52  2.33 μg of Gallic Acid Equivalents per mg of dry plant material. The total phenolic content and 2,2-diphenyl-1-picrylhydrazyl DPPH scavenging activity of the hydroethanolic extract of Salvia tomentosa were determined spectrophotometrically. In terms of wound closure, both 2.5 and 5 S. tomentosa ointments demonstrated wound healing activity comparable to that of Fitokrem. In conclusion, S. tomentosa exibits a positive effect on dermal wound healing in rabbits.

 This study aimed to evaluate the wound healing activity of an ointment containing the hydroethanolic extract of Salvia Tomentosa S. tomentosa in a dermal wound model using rabbits. Ointments with concentrations of 2.5 wv and 5 wv were prepared using the hydroethanolic extracts of S. tomentosa. An in vivo excisional wound model was embloyed with New Zealand rabbits n  35 to assess the wound healing activity of these ointments. Rabbits were randomly divided into five experimental groups: negative received no treatment, vehicle received only the ointment vehicle, positive control treated with Fitokrem, and those treated with 2.5 wv and 5 wv S. tomentosa ointments. Wound diameters were measured using calipers on the 4th, 8th, and 14th days, and histopathological examinations were conducted on the 3rd, 7th, and 14th days of treatment. The total phenolic content of the S. tomentosa hydroethanolic extract was determined to be 61.52  2.33 μg of Gallic Acid Equivalents per mg of dry plant material. The total phenolic content and 2,2-diphenyl-1-picrylhydrazyl DPPH scavenging activity of the hydroethanolic extract of Salvia tomentosa were determined spectrophotometrically. In terms of wound closure, both 2.5 and 5 S. tomentosa ointments demonstrated wound healing activity comparable to that of Fitokrem. In conclusion, S. tomentosa exibits a positive effect on dermal wound healing in rabbits.

Article Details

Effects of Salvia Tomentosa Ointment on Dermal Wound Healing in a Rabbit Model

Authors:

Mehmet Mustafa Demir | Volkan İpek | Hidayet Tutun | Harun Çınar | Leyla Elif Özgü Ayözger

Publisher:

Bursa Uludağ University

Main Topics:

Veterinary Sciences (Other)

Journal:

Journal of Research in Veterinary Medicine Vol.42 Issue 2, pp.54-64

Document Type:

Article

Publication Date:

12/2023

Document Language:

English

Document ID (Org No.):

2001308983

pISSN:

2667-6745

Rabbit

radical scavenging activity

Salvia tomentosa

total phenolic content

wound healingRabbit

radical scavenging activity

Salvia tomentosa

total phenolic content

wound healing

Issues

Article Details

Authors: Mehmet Mustafa Demir | Volkan İpek | Hidayet Tutun | Harun Çınar | Leyla Elif Özgü Ayözger

Publisher: Bursa Uludağ University

Main Topics: Veterinary Sciences (Other)

Journal: Journal of Research in Veterinary Medicine Vol.42 Issue 2, pp.54-64

Document Type: Article

Publication Date: 12/2023

Document Language: English

Document ID (Org No.): 2001308983

pISSN: 2667-6745

Issues

Authors:

Mehmet Mustafa Demir | Volkan İpek | Hidayet Tutun | Harun Çınar | Leyla Elif Özgü Ayözger

Publisher:

Bursa Uludağ University

Main Topics:

Veterinary Sciences (Other)

Journal:

Journal of Research in Veterinary Medicine Vol.42 Issue 2, pp.54-64

Document Type:

Article

Publication Date:

12/2023

Document Language:

English

Document ID (Org No.):

2001308983

pISSN:

2667-6745