Biological effect of alpha-Lipoic Acid on Aflatoxicosis in Broiler chickens

Disouky Mohamed Mourad; Gehad Rashad Donia; Rasha Salah Mohamed; Hanan Saad El-Samahy

Article Details

Biological effect of alpha-Lipoic Acid on Aflatoxicosis in Broiler chickens

Authors:

Disouky Mohamed Mourad | Gehad Rashad Donia | Rasha Salah Mohamed | Hanan Saad El-Samahy

Publisher:

AENSI (American-Eurasian Network for Scientific Information)

Journal:

Australian Journal of Basic and Applied Sciences Vol.14 Issue 1, pp.22-34

Document Type:

Article

Publication Date:

1/2020

Document Language:

English

Document ID (Org No.):

2001858031

pISSN:

1991-8178

Abstract:

 Aflatoxicosis, is still unresolved problem in poultry production caused severe economic losses due to it reduces immunity, damages different tissues, reduces carcass quality and increases susceptibility to infectious diseases, so this work aimed to determine the ability of lipoic acid (universal antioxidant) to ameliorate the harmful effects of aflatoxins in broiler chickens as alternative feed additives and to detect its effect on performance, liver & kidney function, antioxidant status andhistopathological changes. 125one-day old commercial chicks reared under strict hygienic measures and fed basal diet till 8th day of age then 5 chicks were slaughtered and their serum samples were obtained while other 120 chicks were divided into 4 equal groups (n=30),each group subdivided into 3 replicates (10 birds/replicate). Group 1: fed a basal diet (control). Group 2:lipoic acid treated, Group 3:aflatoxicated. Group 4:aflatoxicated with lipoic acid treatment. Body weight, feed intake, signs and mortality were recorded till the end of experiment. Serum samples were collected twice from each group at 14thdays post aflatoxicosis (dpa) and end of experiment, for biochemical analysis.At the end of experimentfour birds from each group were sacrified for gross and histopathological examination of Liver, kidney, intestine and heart. The results revealed no mortalities among different groups till end of experiment, aflatoxicated chickens showed inappetence and loosy fecal matter while gross investigation exhibited petichae on breast and thigh, thymus and spleen were congested &atrophied and liver congested with darkness. Both aflatoxicated and lipoic acid treated chickens revealed significant reduction of body weight from 14th dpa till the end of experiment.Biochemical analysis showed that ALT and AST at 14 dpa were significantly increased in aflatoxicated chickens while at the end of experiment, only creatinine was significantly increased in aflatoxicated chickens and decreased in lipoic acid treated group.finally,SOD, CAT and MDA of all groups exhibited non-significant difference at 14 dpa and the end of experiment. The histopathological examination showedcongestion, necrosis and inflammatory cell infiltration in liver, intestine, kidney and heart ofaflatoxicated group. On the contrary,lipoic acid reduced severity of signs, gross and histopathological changes exhibited by aflatoxins in broiler chickens and improved liver & kidney function tests, antioxidant enzymesand oxidative stress marker when used alone or added to aflatoxicated diet of broilers.So, lipoic acid should be supported to bean alternative feed additive against aflatoxicosis in broiler chickens. [.

Article Details

Biological effect of alpha-Lipoic Acid on Aflatoxicosis in Broiler chickens

Authors: Disouky Mohamed Mourad | Gehad Rashad Donia | Rasha Salah Mohamed | Hanan Saad El-Samahy

Publisher: AENSI (American-Eurasian Network for Scientific Information)

Journal: Australian Journal of Basic and Applied Sciences Vol.14 Issue 1, pp.22-34

Document Type: Article

Publication Date: 1/2020

Document Language: English

Document ID (Org No.): 2001858031

pISSN: 1991-8178

Issues

Authors:

Disouky Mohamed Mourad | Gehad Rashad Donia | Rasha Salah Mohamed | Hanan Saad El-Samahy

Publisher:

AENSI (American-Eurasian Network for Scientific Information)

Journal:

Australian Journal of Basic and Applied Sciences Vol.14 Issue 1, pp.22-34

Document Type:

Article

Publication Date:

1/2020

Document Language:

English

Document ID (Org No.):

2001858031

pISSN:

1991-8178