Effect of Phototherapy on Serum Zinc Level in Neonatal Jaundice

Baiomi , Abdulmagid Mohammed; Hassan , Khaled Hassaan; Besher , Mohammed Ahmed; Mahmoud , Mahmoud Hussein

Article Details

Effect of Phototherapy on Serum Zinc Level in Neonatal Jaundice

Authors:

Baiomi , Abdulmagid Mohammed | Hassan , Khaled Hassaan | Besher , Mohammed Ahmed | Mahmoud , Mahmoud Hussein

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2020 Vol.81 Issue 3, pp.1614-1620

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

230418

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

Keywords:

Abstract:

 Background: Zinc salts can reduce phototherapy duration by precipitating unconjugated bilirubin in the intestinehowever, zinc toxicity is an issue that must be considered. Theoretically, bilirubin reduction by phototherapy mayincrease serum zinc levels, making additional zinc supplementation, which cause zinc toxicity.Objectives: To evaluate serum zinc level alterations before and after phototherapy in hyperbilirubinemicnewborns.Materials and Methods: A prospective cross sectional case-control study was performed at Neonatal IntensiveCare Unit (NICU), Al-Azhar University Hospital, Assiut. 150 newborns aged between 2-7 days divided into 50healthy neonates without hyperbilirubinemia (control group) and 100 neonates with physiological jaundice whorequired phototherapy (case group). Participants were treated according to American Academy of Pediatrics (AAP)criteria. Serum zinc level was measured before and after phototherapy.Results: The mean age of onset was approximately 2 days, while the majority of patients were females anddelivered with cesarean section. The age at admission was 3.09 ± 0.57 days. In regard to our primary outcomes,serum bilirubin level was decreased significantly after phototherapy to reach 8.47 ± 1.36 mg/dl (p < 0.001). Serumzinc level was increased significantly after phototherapy to reach 75.45 ± 14.94 mcg/mL (p < 0.001). Thecomparison between control and study groups regarding serum zinc level showed that there was highly statisticallysignificant difference being higher in case group compared to control group (p < 0.001). Phototherapy was associatedwith a significant increase in serum zinc level in neonates.Conclusions: Phototherapy increases serum zinc level by reducing bilirubin level so additional supplementation ofthis element can lead potentially zinc toxicity.

Article Details

Effect of Phototherapy on Serum Zinc Level in Neonatal Jaundice

Authors:

Baiomi , Abdulmagid Mohammed | Hassan , Khaled Hassaan | Besher , Mohammed Ahmed | Mahmoud , Mahmoud Hussein

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2020 Vol.81 Issue 3, pp.1614-1620

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

230418

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

Descriptors:

NEONATAL DISEASES

HYPERBILIRUBINAEMIA

ZINC

NEWBORNS

EGYPT

Hyperbilirubinemia

Zinc

Phototherapy

Neonatal Jaundice

Issues

Article Details

Authors: Baiomi , Abdulmagid Mohammed | Hassan , Khaled Hassaan | Besher , Mohammed Ahmed | Mahmoud , Mahmoud Hussein

Publisher: Pan Arab League of Continuous Medical Education

Main Topics: Medicine

Journal: The Egyptian Journal of Hospital Medicine 2020 Vol.81 Issue 3, pp.1614-1620

Document Type: Article

Publication Date: 10/2020

Document Language: English

Document ID (Org No.): 230418

Frequency: Quarterly

eISSN: 20907125

pISSN: 16872002

Descriptors:

Issues

Authors:

Baiomi , Abdulmagid Mohammed | Hassan , Khaled Hassaan | Besher , Mohammed Ahmed | Mahmoud , Mahmoud Hussein

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2020 Vol.81 Issue 3, pp.1614-1620

Document Type:

Article

Publication Date:

10/2020

Document Language:

English

Document ID (Org No.):

230418

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002