Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases

Nihal KILINÇ

doi:https://doi.org/10.5472/MMJoa.2802.07

Article Details

Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases

Authors:

Nihal KILINÇ

Publisher:

Marmara University

Main Topics:

Diseases

Journal:

Marmara Medical Journal 2015 Vol.28 Issue 2, pp.99-104

Document Type:

Article

Publication Date:

9/2015

Document Language:

English

Document ID (Org No.):

2000544842

Frequency:

Monthly

eISSN:

1309-9469

pISSN:

1019-1941

DOI:

https://doi.org/10.5472/MMJoa.2802.07

Abstract:

 


Objective: This study explores the correlation between the expression of E-cadherin, p53 tumor suppressor gene, c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases.

Patients and Methods: We have investigated tumor samples from sixty patients with invasive ductal breast carcinoma. 30 of the patients had axillary lymph node metastases and 30 had no axillary lymph node metastases. Tumor tissues of these patients were evaluated by immunohistochemistry for E-cadherin, p53, c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR). 

Results: E-cadherin staining was not expressed in 39 patients (65%) with invasive ductal breast carcinoma. ER, PgR, p53, and c-erb-B2 signals were positive in 36 (60%), 26 (43.3%), 33 (55%), and 29 (48.3%) of the patients, respectively. PgR and c-erb-B2 expression was associated with lymph node metastases (p=0.009, p=0.001, respectively). No association was found between the reduced E-cadherin protein and age. The presence of E-cadherin was associated with axillary lymph node metastases and p53 (p<0.009, p<0.001, respectively).

Conclusion: We found that, the p53 protein may play a role in regulation of E-cadherin protein expression in invasive ductal breast carcinomas with axillary lymph node metastases.

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Amaç: Aksiller lenf nodu metastazlı invaziv duktal meme karsinomda E-cadherin, p53 tümör supressör gen, c-erbB-2 (HER2/neu) ve steroid reseptörleri (ER ve PgR) ekspresyonu arasındaki ilişkiyi araştırmak amaçlanmıştır.Hastalar ve Yöntem: Bu çalışmada, 30 aksiller lenf nodu metastazlı ve 30 aksiller lenf nodu metastazı mevcut olmayan invaziv duktal meme karsinomlu 60 hasta immunokimyasal metodu kullanılarak E-cadherin ve c-erbB-2, ER ve PgR antikorları değerlendirildi.Bulgular: İnvaziv duktal meme karsinomlu 60 hastanın 39’unda (%65) E-cadherin ile boyanma tesbit edilmedi. Sırasıyla ER, PgR, p53, ve c-erb-B2, 60 hastanın 36’ında (%60), 60 hastanın 26’ında (%43,3), 60 hastanın 33’ünde (%55), and 60 hastanın 29’unda (%48,3) pozitif boyanma görüldü. PgR ve c-erb-B2 boyanması lenf nodu metastazı ile ilişkili idi (sırasıyla, p=0,009, p=0,001). E-cadherin proteini ile yaş arasında ilişki görülmedi. E-cadherin ile lenf nodu metastazı ve p53 arasında ilişki görüldü (sırasıyla, p.

Article Details

Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases

Authors: Nihal KILINÇ

Publisher: Marmara University

Main Topics: Diseases

Journal: Marmara Medical Journal 2015 Vol.28 Issue 2, pp.99-104

Document Type: Article

Publication Date: 9/2015

Document Language: English

Document ID (Org No.): 2000544842

Frequency: Monthly

eISSN: 1309-9469

pISSN: 1019-1941

DOI: https://doi.org/10.5472/MMJoa.2802.07

Issues

Authors:

Nihal KILINÇ

Publisher:

Marmara University

Main Topics:

Diseases

Journal:

Marmara Medical Journal 2015 Vol.28 Issue 2, pp.99-104

Document Type:

Article

Publication Date:

9/2015

Document Language:

English

Document ID (Org No.):

2000544842

Frequency:

Monthly

eISSN:

1309-9469

pISSN:

1019-1941

DOI:

https://doi.org/10.5472/MMJoa.2802.07