Development and ın vitro characterization of embelin bilosomes for enhanced oral bioavailability

Dhanashree Sanap; Sneha Agrawal

Article Details

Development and ın vitro characterization of embelin bilosomes for enhanced oral bioavailability

Authors:

Dhanashree Sanap | Sneha Agrawal

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.29 Issue 4, pp.1616-1626

Document Type:

Article

Publication Date:

5/2025

Document Language:

English

Document ID (Org No.):

2001342442

pISSN:

2630-6344

Keywords:

Abstract:

 The goal of this study was to formulate a nanotechnology-based system incorporating surfactants, cholesterol CHL, and sodium deoxycholate SDC and optimization was done using central composite design of design-expert software. The variables used were X1 Surfactant; Span 80 and X2 Bile salt; SDC. In vitro, release kinetics assessment of the drug revealed an increase in drug release of the drug. Transmission electron microscopy TEM exhibited a round shape of developed bilosomes with few having rough surfaces. Fourier Transform Infrared Spectroscopy FT-IR data exhibited no specific physiochemical interaction between active and additives. Differential scanning calorimetry DSC studies showed the molecular state and the indication of no interactions among the formulation ingredients. The mean vesicle size, polydispersity index, zeta potential, and entrapment efficiency  of optimized bilosome formulation were observed to be 211.1 nm, 0.513, 47.8 mV, and 99.664  respectively. Overall, the obtained results confirmed that Embelin-loaded bilosome could be promising for oral drug delivery.

 The goal of this study was to formulate a nanotechnology-based system incorporating surfactants, cholesterol CHL, and sodium deoxycholate SDC and optimization was done using central composite design of design-expert software. The variables used were X1 Surfactant; Span 80 and X2 Bile salt; SDC. In vitro, release kinetics assessment of the drug revealed an increase in drug release of the drug. Transmission electron microscopy TEM exhibited a round shape of developed bilosomes with few having rough surfaces. Fourier Transform Infrared Spectroscopy FT-IR data exhibited no specific physiochemical interaction between active and additives. Differential scanning calorimetry DSC studies showed the molecular state and the indication of no interactions among the formulation ingredients. The mean vesicle size, polydispersity index, zeta potential, and entrapment efficiency  of optimized bilosome formulation were observed to be 211.1 nm, 0.513, 47.8 mV, and 99.664  respectively. Overall, the obtained results confirmed that Embelin-loaded bilosome could be promising for oral drug delivery.

 The goal of this study was to formulate a nanotechnology-based system incorporating surfactants, cholesterol CHL, and sodium deoxycholate SDC and optimization was done using central composite design of design-expert software. The variables used were X1 Surfactant; Span 80 and X2 Bile salt; SDC. In vitro, release kinetics assessment of the drug revealed an increase in drug release of the drug. Transmission electron microscopy TEM exhibited a round shape of developed bilosomes with few having rough surfaces. Fourier Transform Infrared Spectroscopy FT-IR data exhibited no specific physiochemical interaction between active and additives. Differential scanning calorimetry DSC studies showed the molecular state and the indication of no interactions among the formulation ingredients. The mean vesicle size, polydispersity index, zeta potential, and entrapment efficiency  of optimized bilosome formulation were observed to be 211.1 nm, 0.513, 47.8 mV, and 99.664  respectively. Overall, the obtained results confirmed that Embelin-loaded bilosome could be promising for oral drug delivery.

 The goal of this study was to formulate a nanotechnology-based system incorporating surfactants, cholesterol CHL, and sodium deoxycholate SDC and optimization was done using central composite design of design-expert software. The variables used were X1 Surfactant; Span 80 and X2 Bile salt; SDC. In vitro, release kinetics assessment of the drug revealed an increase in drug release of the drug. Transmission electron microscopy TEM exhibited a round shape of developed bilosomes with few having rough surfaces. Fourier Transform Infrared Spectroscopy FT-IR data exhibited no specific physiochemical interaction between active and additives. Differential scanning calorimetry DSC studies showed the molecular state and the indication of no interactions among the formulation ingredients. The mean vesicle size, polydispersity index, zeta potential, and entrapment efficiency  of optimized bilosome formulation were observed to be 211.1 nm, 0.513, 47.8 mV, and 99.664  respectively. Overall, the obtained results confirmed that Embelin-loaded bilosome could be promising for oral drug delivery.

Article Details

Development and ın vitro characterization of embelin bilosomes for enhanced oral bioavailability

Authors:

Dhanashree Sanap | Sneha Agrawal

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.29 Issue 4, pp.1616-1626

Document Type:

Article

Publication Date:

5/2025

Document Language:

English

Document ID (Org No.):

2001342442

pISSN:

2630-6344

Embelin

bilosomes

nanocarriers

anti-microbial

entrapment efficiency

zeta potential

particle size

Issues

Article Details

Authors: Dhanashree Sanap | Sneha Agrawal

Publisher: Marmara University

Main Topics: Pharmacology and Pharmaceutical Sciences (Other)

Journal: Journal of Research in Pharmacy Vol.29 Issue 4, pp.1616-1626

Document Type: Article

Publication Date: 5/2025

Document Language: English

Document ID (Org No.): 2001342442

pISSN: 2630-6344

Issues

Authors:

Dhanashree Sanap | Sneha Agrawal

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.29 Issue 4, pp.1616-1626

Document Type:

Article

Publication Date:

5/2025

Document Language:

English

Document ID (Org No.):

2001342442

pISSN:

2630-6344