Cryptococcal Cellulitis in a Diabetic with Nephropathy on Adalimumab Therapy for Rheumatoid Arthritis

Christine A. Moore; Imranali Khan; Almira Opardija

doi:https://doi.org/10.5799/jmid.367623

Article Details

Cryptococcal Cellulitis in a Diabetic with Nephropathy on Adalimumab Therapy for Rheumatoid Arthritis

Authors:

Christine A. Moore | Imranali Khan | Almira Opardija

Publisher:

Sağlık Araştırmaları Derneği

Journal:

Journal of Microbiology and Infectious Diseases 2017 Vol.07 Issue 03, pp.160-163

Document Type:

Article

Publication Date:

9/2017

Document Language:

Turkish

Document ID (Org No.):

2000487474

Frequency:

Quarterly

eISSN:

2146-9369

pISSN:

2146-3158

DOI:

https://doi.org/10.5799/jmid.367623

Abstract:

 

Cutaneous
infection with Cryptococcus neoformans is rare but can occur in the setting of
rheumatoid arthritis due to immunosuppression. Risk factors include chronic
kidney disease and use of tumor necrosis factor-alpha (TNF-α) inhibitor
adalimumab. We report the fourth case of primary cutaneous cryptococcosis (PCC)
in a diabetic female more than 60 years old living in rural Northwest Tennessee
and taking adalimumab for rheumatoid arthritis. In a literature review of
existing cases, this is the second case involving simultaneous chronic kidney
disease and the first case in a diabetic and following extended TNF-α inhibitor
immunosuppression monotherapy. Physicians should consider cryptococcal
infection in a patient who develops cellulitis that is unresponsive to empiric
therapy. In addition, it is imperative to monitor rheumatoid arthritis patients
taking adalimumab closely and consider alternative agents in those with
pre-existing immunosuppression or known risk factors for opportunistic
infections as primary prevention. .

Article Details

Cryptococcal Cellulitis in a Diabetic with Nephropathy on Adalimumab Therapy for Rheumatoid Arthritis

Authors: Christine A. Moore | Imranali Khan | Almira Opardija

Publisher: Sağlık Araştırmaları Derneği

Journal: Journal of Microbiology and Infectious Diseases 2017 Vol.07 Issue 03, pp.160-163

Document Type: Article

Publication Date: 9/2017

Document Language: Turkish

Document ID (Org No.): 2000487474

Frequency: Quarterly

eISSN: 2146-9369

pISSN: 2146-3158

DOI: https://doi.org/10.5799/jmid.367623

Issues

Authors:

Christine A. Moore | Imranali Khan | Almira Opardija

Publisher:

Sağlık Araştırmaları Derneği

Journal:

Journal of Microbiology and Infectious Diseases 2017 Vol.07 Issue 03, pp.160-163

Document Type:

Article

Publication Date:

9/2017

Document Language:

Turkish

Document ID (Org No.):

2000487474

Frequency:

Quarterly

eISSN:

2146-9369

pISSN:

2146-3158

DOI:

https://doi.org/10.5799/jmid.367623