A speedy method for simultaneous determination in tablet active content by NIR and UV-Vis spectrophotometry: Comparison of PLS-1 and ICA-ANN models

Ahmet Hakan AKTAŞ; Halil Orhun ŞAHİN

doi:https://doi.org/10.35378/gujs.752042

Article Details

A speedy method for simultaneous determination in tablet active content by NIR and UV-Vis spectrophotometry: Comparison of PLS-1 and ICA-ANN models

Authors:

Ahmet Hakan AKTAŞ | Halil Orhun ŞAHİN

Publisher:

Gazi University

Main Topics:

Applied physics

Journal:

Gazi University Journal of Science 2021 Vol.34 Issue 2, pp.370-379

Document Type:

Article

Publication Date:

5/2021

Document Language:

English

Document ID (Org No.):

2000427626

eISSN:

2147-1762

DOI:

https://doi.org/10.35378/gujs.752042

Abstract:

 

In this study, the NIR and UV-Vis spectroscopy methods, which are frequently used in pharmaceutical industry, were applied to the environments where Paracetamol, Propyphenazone and Caffeine active substances are present, and the spectroscopic data obtained were evaluated comparatively with ICA-ANN and PLS-1, which are powerful chemometric methods. When using solid agents in NIR method, liquid solutions equivalent to them were used in UV-Vis method. Following the application of both methods, spectral data were evaluated as chemometrics and in both spectroscopic methods ICA-ANN method yielded more accurate results than PLS-1. High recovery rates and relatively low standard deviations were found in the applied methods and recommended for use in the pharmaceutical industry.

Article Details

A speedy method for simultaneous determination in tablet active content by NIR and UV-Vis spectrophotometry: Comparison of PLS-1 and ICA-ANN models

Authors: Ahmet Hakan AKTAŞ | Halil Orhun ŞAHİN

Publisher: Gazi University

Main Topics: Applied physics

Journal: Gazi University Journal of Science 2021 Vol.34 Issue 2, pp.370-379

Document Type: Article

Publication Date: 5/2021

Document Language: English

Document ID (Org No.): 2000427626

eISSN: 2147-1762

DOI: https://doi.org/10.35378/gujs.752042

Issues

Authors:

Ahmet Hakan AKTAŞ | Halil Orhun ŞAHİN

Publisher:

Gazi University

Main Topics:

Applied physics

Journal:

Gazi University Journal of Science 2021 Vol.34 Issue 2, pp.370-379

Document Type:

Article

Publication Date:

5/2021

Document Language:

English

Document ID (Org No.):

2000427626

eISSN:

2147-1762

DOI:

https://doi.org/10.35378/gujs.752042