Histologic Evaluation in Patients with Benign  Prostatic Hyperplasia Treated with Finasteride  and Surgery Alone

Özkan POLAT

Article Details

Histologic Evaluation in Patients with Benign Prostatic Hyperplasia Treated with Finasteride and Surgery Alone

Authors:

Özkan POLAT

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 2, pp.157-162

Document Type:

Article

Publication Date:

1/1998

Document Language:

Turkish

Document ID (Org No.):

2000758448

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Keywords:

Abstract:

 

In this study, we compared stroma,  epithelium, glandular lumen, smooth  muscle hyperplasia, inflammation and fibrous  components in benign prostatic hyperplasia  (BPH) tissue between the group undergone  surgery only and the group who had taken finasteride  (5 alpha-reductase inhibitor) prior  to surgical treatment.  Prostate adenomas were obtained from both  12 patients administered finasteride for six  months prior to surgical treatment and  those of 11 patients undergone only surgical  treatment. The histological evaluation were  performed quantitatively by planimetry.  The mean epithelium ratio in the group administered  5 alpha-reductase inhibitor prior  to surgery lessened approximately twofold  compared to the other group's.  In conclusion, morphometric analysis may  have an indicative role in determining alternative  pharmacotherapies for BPH.

 

In this study, we compared stroma,  epithelium, glandular lumen, smooth  muscle hyperplasia, inflammation and fibrous  components in benign prostatic hyperplasia  (BPH) tissue between the group undergone  surgery only and the group who had taken finasteride  (5 alpha-reductase inhibitor) prior  to surgical treatment.  Prostate adenomas were obtained from both  12 patients administered finasteride for six  months prior to surgical treatment and  those of 11 patients undergone only surgical  treatment. The histological evaluation were  performed quantitatively by planimetry.  The mean epithelium ratio in the group administered  5 alpha-reductase inhibitor prior  to surgery lessened approximately twofold  compared to the other group's.  In conclusion, morphometric analysis may  have an indicative role in determining alternative  pharmacotherapies for BPH.

Article Details

Histologic Evaluation in Patients with Benign Prostatic Hyperplasia Treated with Finasteride and Surgery Alone

Authors:

Özkan POLAT

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 2, pp.157-162

Document Type:

Article

Publication Date:

1/1998

Document Language:

Turkish

Document ID (Org No.):

2000758448

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

5 alpha-reductase inhibitor

morphometric analysis

Histology of benign prostatic hyperplasia.

Issues

Article Details

Histologic Evaluation in Patients with Benign Prostatic Hyperplasia Treated with Finasteride and Surgery Alone

Authors: Özkan POLAT

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 1998 Vol.28 Issue 2, pp.157-162

Document Type: Article

Publication Date: 1/1998

Document Language: Turkish

Document ID (Org No.): 2000758448

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

5 alpha-reductase inhibitor

morphometric analysis

Histology of benign prostatic hyperplasia.

Issues

Authors:

Özkan POLAT

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 1998 Vol.28 Issue 2, pp.157-162

Document Type:

Article

Publication Date:

1/1998

Document Language:

Turkish

Document ID (Org No.):

2000758448

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144