Effect of microsatellite instability on histopathological parameters and prognosis in colon cancers

Tuğba Toyran; Kivilcim Erdogan; Emine Kılıç Bağır; Arbil Açıkalın; Merve Aksın; Semra Paydaş; Burak Mete; Seyda Erdogan

Article Details

Effect of microsatellite instability on histopathological parameters and prognosis in colon cancers

Authors:

Tuğba Toyran | Kivilcim Erdogan | Emine Kılıç Bağır | Arbil Açıkalın | Merve Aksın | Semra Paydaş | Burak Mete | Seyda Erdogan

Publisher:

Cukurova University

Main Topics:

Klinik Tıp Bilimleri

Journal:

Cukurova Medical Journal Vol.48 Issue 1, pp.1-10

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001282240

pISSN:

2602-3032

Keywords:

Abstract:

 Purpose: The aim of this study was to compare the clinicopathological features, while evaluating the frequency of MSI, and the survival rates in these patients in our patient group with MSI and microsatellite stabil MSS colorectal carcinomas CRCs. Materials and Methods: We retrospectively enrolled 146 patients who underwent colon resection between the years of 2014-2022. The expression of MSI status was evaluated by immunohistochemistry. The association of MSI status, presense of tumor-infiltrating lymphocytes TILs, and tumor budding score with a patients survival was assessed by the KaplanMeier method and Cox regression analysis. Results: There were 104 71.2 MSS cases and, 42 28.8 MSI cases. 15 10.3 MSI tumors were found to be MSI-low, and 27 18.5 to be MSI-high. MSI tumors were significantly associated with younger patients 50, earlier stage T1-T2, right localization, lower rate of lymph node metastasis, presence of mucinous component and TILs response. The Cox-regression model revealed TILs, tumor budding score, and MSI are variables that significantly affect survival. The presence of TILs exhibited a protective effect Hazard ratio HR0.446, which decreased the mortality risk by 2.24 times for the follow-up period, while the presence of high TBS increased the risk of mortality by HR3.22. Conclusion: This study revealed that patients with MSI CRCs may show unique clinicopathological features and should be evaluated using some guiding parameters that will improve survival.

 Purpose: The aim of this study was to compare the clinicopathological features, while evaluating the frequency of MSI, and the survival rates in these patients in our patient group with MSI and microsatellite stabil MSS colorectal carcinomas CRCs. Materials and Methods: We retrospectively enrolled 146 patients who underwent colon resection between the years of 2014-2022. The expression of MSI status was evaluated by immunohistochemistry. The association of MSI status, presense of tumor-infiltrating lymphocytes TILs, and tumor budding score with a patients survival was assessed by the KaplanMeier method and Cox regression analysis. Results: There were 104 71.2 MSS cases and, 42 28.8 MSI cases. 15 10.3 MSI tumors were found to be MSI-low, and 27 18.5 to be MSI-high. MSI tumors were significantly associated with younger patients 50, earlier stage T1-T2, right localization, lower rate of lymph node metastasis, presence of mucinous component and TILs response. The Cox-regression model revealed TILs, tumor budding score, and MSI are variables that significantly affect survival. The presence of TILs exhibited a protective effect Hazard ratio HR0.446, which decreased the mortality risk by 2.24 times for the follow-up period, while the presence of high TBS increased the risk of mortality by HR3.22. Conclusion: This study revealed that patients with MSI CRCs may show unique clinicopathological features and should be evaluated using some guiding parameters that will improve survival.

 Purpose: The aim of this study was to compare the clinicopathological features, while evaluating the frequency of MSI, and the survival rates in these patients in our patient group with MSI and microsatellite stabil MSS colorectal carcinomas CRCs. Materials and Methods: We retrospectively enrolled 146 patients who underwent colon resection between the years of 2014-2022. The expression of MSI status was evaluated by immunohistochemistry. The association of MSI status, presense of tumor-infiltrating lymphocytes TILs, and tumor budding score with a patients survival was assessed by the KaplanMeier method and Cox regression analysis. Results: There were 104 71.2 MSS cases and, 42 28.8 MSI cases. 15 10.3 MSI tumors were found to be MSI-low, and 27 18.5 to be MSI-high. MSI tumors were significantly associated with younger patients 50, earlier stage T1-T2, right localization, lower rate of lymph node metastasis, presence of mucinous component and TILs response. The Cox-regression model revealed TILs, tumor budding score, and MSI are variables that significantly affect survival. The presence of TILs exhibited a protective effect Hazard ratio HR0.446, which decreased the mortality risk by 2.24 times for the follow-up period, while the presence of high TBS increased the risk of mortality by HR3.22. Conclusion: This study revealed that patients with MSI CRCs may show unique clinicopathological features and should be evaluated using some guiding parameters that will improve survival.

 Amaç: Bu çalışmada, MSİ ile mikrosatellit stabil MSS kolorektal karsinomlu KRK hasta grubumuzda, klinikopatolojik özellikleri karşılaştırmayı, MSİ sıklığını ve bu hastalarda sağkalım oranlarını değerlendirmeyi amaçladık Gereç ve Yöntem: Çalışmaya retrospektif olarak 2014-2022 yılları arasında kolon rezeksiyonu yapılan 146 hasta dahil edildi. MSI durumu, immünohistokimyal belirteçlerle değerlendirildi. MSI durumu, tümörü infiltre eden lenfositlerin TILler varlığı ve tümör tomurcuklanma skorunun sağkalım ile olan ilişkisi, Kaplan-Meier yöntemi ve Cox regresyon analizi ile değerlendirildi. Bulgular: Olgularımızın 104ü 71,2 MSS, 42si 28,8 MSİdir. MSI tümörlerin 15i 10,3 MSI-düşük, 27si 18,5 MSİ-yüksek olarak bulundu. MSİ tümörler, genç yaş 50 yaş, erken evre T1-T2, sağ kolon lokalizasyonu, düşük lenf nodu metastazı oranı, müsinöz komponent ve TİL varlığı ile istatistiksel olarak anlamlı şekilde ilişkiliydi. Cox-regresyon modeli, TILlerin, tümör tomurcuklanma skorunun ve MSİnin sağkalımı önemli ölçüde etkileyen değişkenler olduğunu ortaya çıkardı. TILlerin varlığı, takip süresince ölüm riskini 2,24 kat azaltan koruyucu bir etki Tehlike oranı HR0,446 sergilerken, yüksek tümör tomurcuklanma skorunun ölüm riskini HR3,22 artırdığı bulundu. Sonuç: Çalışmamızda, MSİ KRKli hastaların, kendilerine özgü klinikopatolojik özellikler gösterebileceği ve sağkalımda yol gösterici bazı parametrelerle birlikte değerlendirilmesi gerektiği vurgulanmaktadır.

Article Details

Effect of microsatellite instability on histopathological parameters and prognosis in colon cancers

Authors:

Tuğba Toyran | Kivilcim Erdogan | Emine Kılıç Bağır | Arbil Açıkalın | Merve Aksın | Semra Paydaş | Burak Mete | Seyda Erdogan

Publisher:

Cukurova University

Main Topics:

Klinik Tıp Bilimleri

Journal:

Cukurova Medical Journal Vol.48 Issue 1, pp.1-10

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001282240

pISSN:

2602-3032

Colorectal carcinomas

microsatellite instability

tumor-infiltrating lymphocytes

tumor budding score

Kolon kanser

mikrosatellite instabilite

histopatolojik parametre

Kolon kanseri

mikrosatellite instabilite

histopatolojik parametre

prognoz

Issues

Article Details

Authors: Tuğba Toyran | Kivilcim Erdogan | Emine Kılıç Bağır | Arbil Açıkalın | Merve Aksın | Semra Paydaş | Burak Mete | Seyda Erdogan

Publisher: Cukurova University

Main Topics: Klinik Tıp Bilimleri

Journal: Cukurova Medical Journal Vol.48 Issue 1, pp.1-10

Document Type: Article

Publication Date: 3/2023

Document Language: English

Document ID (Org No.): 2001282240

pISSN: 2602-3032

Issues

Authors:

Tuğba Toyran | Kivilcim Erdogan | Emine Kılıç Bağır | Arbil Açıkalın | Merve Aksın | Semra Paydaş | Burak Mete | Seyda Erdogan

Publisher:

Cukurova University

Main Topics:

Klinik Tıp Bilimleri

Journal:

Cukurova Medical Journal Vol.48 Issue 1, pp.1-10

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001282240

pISSN:

2602-3032