Modulation of PTEN by hexarelin attenuates coronary artery ligation-induced heart failure in rats

Elvis AGBO; Donghai LIU; Meixiu LI; Roland Osei SAAHENE; Liqiang CHEN; Junpeng ZHAO; Yiquan WANG; Guozhong TIAN

Article Details

Modulation of PTEN by hexarelin attenuates coronary artery ligation-induced heart failure in rats

Authors:

Elvis AGBO | Donghai LIU | Meixiu LI | Roland Osei SAAHENE | Liqiang CHEN | Junpeng ZHAO | Yiquan WANG | Guozhong TIAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 3, pp.946-958

Document Type:

Article

Publication Date:

5/2019

Document Language:

English

Document ID (Org No.):

2000750147

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Abstract:

 

Background/aim:  Hexarelin  is  a  synthetic  growth  hormone-releasing  peptide  that  exerts  cardioprotective  effects.  However,  its  cardioprotective effect against heart failure (HF) is yet to be explained. This study investigated the therapeutic role of hexarelin and the mechanisms underlying its cardioprotective effects against coronary artery ligation (CAL)-induced HF in rats. Materials and methods: Rats with four weeks of permanent CAL, induced myocardial infarction, and HF were randomly separated into four groups: the control group (Ctrl), sham group (Sham), hexarelin treatment group (HF + Hx), and heart failure group (HF). The rats were treated with subcutaneous injection of hexarelin (100 μg/kg) in the treatment group or saline in the other groups twice a day for 30 days. Left ventricular (LV) function, oxidative stress, apoptosis, molecular analyses, and cardiac structural and pathological changes in rats were assessed.Results: The treatment of HF rats with hexarelin significantly induced the upregulation of phosphatase and tensin homologue (PTEN) expression and inhibited the phosphorylation of protein kinase B (Akt) and mammalian target of rapamycin (mTOR) to significantly improve LV function, ameliorate myocardial remodeling, and reduce oxidative stress. Conclusion:  These  findings  indicate  that  hexarelin  attenuates  CAL-induced  HF  in  rats  by  ameliorating  myocardial  remodeling,  LV  dysfunction, and oxidative stress via the upmodulation of PTEN signaling and downregulation of the Akt/mTOR signaling pathway.

Article Details

Modulation of PTEN by hexarelin attenuates coronary artery ligation-induced heart failure in rats

Authors: Elvis AGBO | Donghai LIU | Meixiu LI | Roland Osei SAAHENE | Liqiang CHEN | Junpeng ZHAO | Yiquan WANG | Guozhong TIAN

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 3, pp.946-958

Document Type: Article

Publication Date: 5/2019

Document Language: English

Document ID (Org No.): 2000750147

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Issues

Authors:

Elvis AGBO | Donghai LIU | Meixiu LI | Roland Osei SAAHENE | Liqiang CHEN | Junpeng ZHAO | Yiquan WANG | Guozhong TIAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 3, pp.946-958

Document Type:

Article

Publication Date:

5/2019

Document Language:

English

Document ID (Org No.):

2000750147

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144