TAKSAN SINIFI BİLEŞİKLERİN ANTİTÜMÖR ETKİLERİ :

Nurgün ERDEMOĞLU; Bilge ŞENER

doi:https://doi.org/10.1501/Eczfak_0000000343

Article Details

TAKSAN SINIFI BİLEŞİKLERİN ANTİTÜMÖR ETKİLERİ :

Authors:

Nurgün ERDEMOĞLU | Bilge ŞENER

Publisher:

Ankara University

Journal:

Journal of Faculty of Pharmacy of Ankara University 2000 Vol.29 Issue 1

Document Type:

Article

Publication Date:

5/2000

Document Language:

Turkish

Document ID (Org No.):

2000868377

Frequency:

Tri-annual

eISSN:

2564-6524

pISSN:

1015-3918

DOI:

https://doi.org/10.1501/Eczfak_0000000343

Keywords:

Abstract:

 

The taxane class agents (paclitaxel and docetaxel) are the one of the most important cancer chemotherapeutics in the past several years. Paclitaxel, one of microtubule-stabilizing anticancer agents, was first obtained from the bark of the Pacific yew (Taxus brevifolia Nutt.) in 1971. Docetaxel is semisynthetically derived from 10-deacetylbaccatin HI extracted from the needles of the European yew (Taxus baccata L.). Both drugs are very similar in mechanism of action, preclinical and clinical activities. In this article, the recent clinical trials and structure-activity relationships of paclitaxel (Taxol ) and docetaxel (Taxotere ) have been reviewed.

 

Taksan sınıfı bileşikler (paklitaksel ve dosetaksel) son yılların en önemli kanser kemoterapötiklerindendir. Mikrotubullerin stabil halde kalmasını sağlayan paklitaksel, ilk defa ABD'de yetişen Taxus brevifolia Nutt.'nın kabuğundan 1971 yılında elde edilmiştir. Dosetaksel, Avrupa'da yetişen Taxus baccata'nın yapraklarından ekstre edilen 10-deasetilbakkatin III'den yarısentez sonucu elde edilmiştir. Her iki ilaç benzer etki mekanizması, preklinik ve klinik aktivitelere sahiptir. Bu makalede, paklitaksel (Taxol ) ve dosetaksel (Taxotere ) üzerinde son yıllarda yapılan klinik araştırmalar ve yapı-aktivite ilişkilerine ait bilgiler verilmektedir.

Article Details

TAKSAN SINIFI BİLEŞİKLERİN ANTİTÜMÖR ETKİLERİ :

Authors:

Nurgün ERDEMOĞLU | Bilge ŞENER

Publisher:

Ankara University

Journal:

Journal of Faculty of Pharmacy of Ankara University 2000 Vol.29 Issue 1

Document Type:

Article

Publication Date:

5/2000

Document Language:

Turkish

Document ID (Org No.):

2000868377

Frequency:

Tri-annual

eISSN:

2564-6524

pISSN:

1015-3918

DOI:

https://doi.org/10.1501/Eczfak_0000000343

Antikanser

paklitaksel

dosetaksel

Taksol

Taxotere

mikrotubul

kanser

Issues

Article Details

Authors: Nurgün ERDEMOĞLU | Bilge ŞENER

Publisher: Ankara University

Journal: Journal of Faculty of Pharmacy of Ankara University 2000 Vol.29 Issue 1

Document Type: Article

Publication Date: 5/2000

Document Language: Turkish

Document ID (Org No.): 2000868377

Frequency: Tri-annual

eISSN: 2564-6524

pISSN: 1015-3918

DOI: https://doi.org/10.1501/Eczfak_0000000343

Issues

Authors:

Nurgün ERDEMOĞLU | Bilge ŞENER

Publisher:

Ankara University

Journal:

Journal of Faculty of Pharmacy of Ankara University 2000 Vol.29 Issue 1

Document Type:

Article

Publication Date:

5/2000

Document Language:

Turkish

Document ID (Org No.):

2000868377

Frequency:

Tri-annual

eISSN:

2564-6524

pISSN:

1015-3918

DOI:

https://doi.org/10.1501/Eczfak_0000000343