The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty

Davut BOZKAYA; Ebru ERGENEKON; Aysegul YUCEL; Sengul OZDEK; İbrahim HİRFANOGLU; Ozden TURAN; Canan TURKYİLMAZ; Esra ONAL; Esin KOC; Yıldız ATALAY

Article Details

The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty

Authors:

Davut BOZKAYA | Ebru ERGENEKON | Aysegul YUCEL | Sengul OZDEK | İbrahim HİRFANOGLU | Ozden TURAN | Canan TURKYİLMAZ | Esra ONAL | Esin KOC | Yıldız ATALAY

Publisher:

Rabia YILMAZ

Main Topics:

Promotion of health

Journal:

Çağdaş Tıp Dergisi 2019 Vol.9 Issue 1, pp.9-14

Document Type:

Article

Publication Date:

3/2019

Document Language:

English

Document ID (Org No.):

2000497421

Frequency:

Bimonthly

eISSN:

2667-7180

Abstract:

 


Introduction:
Most important factors in retinopathy of prematurity (ROP) are prematurity and
oxygen toxicity although blood transfusions, insulin like growth factor-1 (
IGF-1), insulin like growth factor binding protein 3 (IGFBP-3) and vascular
endothelial growth factor (VEGF) also have important roles.


The
objectives of this study were, to measure IGF-1 and IGFBP-3 levels in preterm
newborns before and after blood transfusion and assess if the effect of
transfusion in development of ROP is via these mediators, and to investigate
whether IGF-1 and IGFBP-3 levels measured at 32 and 33 gestational age (GA)
were different in preterm newborns with and without ROP.


Material
and Methods: Preterm newborns with gestational age ≤34 weeks were included and
blood samples were obtained before and after red blood cell (RBC) transfusion.


Results:
Thirty newborns were included, 17 of whom had ROP ( stage 1: n=11, stage 2:
n=5, stage 3: n=1). IGF-1 and IGFBP-3 levels did not change after RBC
tranfusion. Excluding the patient with stage 3 ROP all ROP patients were
referred as mild ROP. No difference was observed between IGF-1 and IGFBP-3
levels of the patients with and without mild ROP. Patients with mild ROP had
significantly more number of transfusions.


Conclusions:
Erythrocyte transfusion increased the frequency of ROP, whereas IGFBP-3 and
IGF-1 were not associated of ROP.


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Article Details

The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty

Authors: Davut BOZKAYA | Ebru ERGENEKON | Aysegul YUCEL | Sengul OZDEK | İbrahim HİRFANOGLU | Ozden TURAN | Canan TURKYİLMAZ | Esra ONAL | Esin KOC | Yıldız ATALAY

Publisher: Rabia YILMAZ

Main Topics: Promotion of health

Journal: Çağdaş Tıp Dergisi 2019 Vol.9 Issue 1, pp.9-14

Document Type: Article

Publication Date: 3/2019

Document Language: English

Document ID (Org No.): 2000497421

Frequency: Bimonthly

eISSN: 2667-7180

Issues

Authors:

Davut BOZKAYA | Ebru ERGENEKON | Aysegul YUCEL | Sengul OZDEK | İbrahim HİRFANOGLU | Ozden TURAN | Canan TURKYİLMAZ | Esra ONAL | Esin KOC | Yıldız ATALAY

Publisher:

Rabia YILMAZ

Main Topics:

Promotion of health

Journal:

Çağdaş Tıp Dergisi 2019 Vol.9 Issue 1, pp.9-14

Document Type:

Article

Publication Date:

3/2019

Document Language:

English

Document ID (Org No.):

2000497421

Frequency:

Bimonthly

eISSN:

2667-7180