THE EFFECT OF SALVIA FRUTICOSA WATER EXTRACT IN ACETIC-ACID-INDUCED COLITIS IN MICE

Rim Mrad; Suzana Salhab; Miriam Al-Battal; Jamilah Borjac

Article Details

THE EFFECT OF SALVIA FRUTICOSA WATER EXTRACT IN ACETIC-ACID-INDUCED COLITIS IN MICE

Authors:

Rim Mrad | Suzana Salhab | Miriam Al-Battal | Jamilah Borjac

Publisher:

Beirut Arab University Press

Journal:

BAU Journal - Science and Technology Vol.3 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

6/2022

Document Language:

English

Document ID (Org No.):

2001951525

pISSN:

2959-331X

Keywords:

Abstract:

 Inflammatory bowel disease (IBD) including Ulcerative colitis (UC) and Crohn’s disease, is a chronic condition of the intestine characterized by an uncontrolled inflammatory response. Current biologic treatments developed to treat IBD are expensive and associated with significant side effects; thus, alternative approaches are required. Recently, herbal concoctions have emerged as promising intervention. This study investigates the protective effects of Salvia fruticosa (SF) against acetic acid-induced colitis in mice, a model of human inflammatory bowel disease (IBD). Mice were divided into four groups (n=3). IBD was induced with acetic acid (6%). SF was administered by gavage at 1.5ug/kg mimicking folk medicine. SF treatment was given for 2, 4 & 6 days. After treatment, colons were collected for colonic biochemical markers, and histopathological evaluation. SF treatment induced enhancement in the colon’s structure and decreased ulcerations and inflammation. It significantly decreased pro-inflammatory cytokines TNF-α, IL-17 by 2.1-fold and 0.9-fold respectively at day2 and 6 and IL-6 by 2.8-fold at day 2 & 1.7-fold at day 6. Also, pro-inflammatory cytokine INF-γ showed a significant 22-fold decrease at day2 in SF-treated colitic group. Moreover, Myeloperoxidase (MPO) and Malondialdehyde (MDA) levels decreased showing the anti-oxidant property of the extract. Anti-oxidant Glutathione (GSH) level and anti-inflammatory cytokine IL-10, remained at normal levels while an increase by 0.9-fold at day 2 and 0.5-fold at day 6 in anti-inflammatory cytokine TGF-β in healthy SF-treated groups was significant. Hence, Salvia fruticosa exerts an anti-inflammatory and anti-oxidant effects against IBD as well as it help healing colon ulcers and maintain its architecture.

Article Details

THE EFFECT OF SALVIA FRUTICOSA WATER EXTRACT IN ACETIC-ACID-INDUCED COLITIS IN MICE

Authors:

Rim Mrad | Suzana Salhab | Miriam Al-Battal | Jamilah Borjac

Publisher:

Beirut Arab University Press

Journal:

BAU Journal - Science and Technology Vol.3 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

6/2022

Document Language:

English

Document ID (Org No.):

2001951525

pISSN:

2959-331X

Inflammatory Bowel Disease

Crohn’s Disease

Ulcerative Colitis

Cytokines

Myeloperoxidase

Glutathione

Malondyaldehyde.

Issues

Article Details

Authors: Rim Mrad | Suzana Salhab | Miriam Al-Battal | Jamilah Borjac

Publisher: Beirut Arab University Press

Journal: BAU Journal - Science and Technology Vol.3 Issue 2, pp.0-0

Document Type: Article

Publication Date: 6/2022

Document Language: English

Document ID (Org No.): 2001951525

pISSN: 2959-331X

Issues

Authors:

Rim Mrad | Suzana Salhab | Miriam Al-Battal | Jamilah Borjac

Publisher:

Beirut Arab University Press

Journal:

BAU Journal - Science and Technology Vol.3 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

6/2022

Document Language:

English

Document ID (Org No.):

2001951525

pISSN:

2959-331X