Determination of the pharmacokinetics of marbofloxacin in endotoxemic sheep

Devran COŞKUN; Orhan ÇORUM; Enver YAZAR

Article Details

Determination of the pharmacokinetics of marbofloxacin in endotoxemic sheep

Authors:

Devran COŞKUN | Orhan ÇORUM | Enver YAZAR

Publisher:

The Chamber of Veterinary Surgeons, Istanbul

Main Topics:

Animal husbandry

Journal:

Journal of Istanbul Veterinary Sciences 2020, pp.42-42

Document Type:

Article

Publication Date:

3/2020

Document Language:

English

Document ID (Org No.):

2000485277

Frequency:

Tri-annual

eISSN:

2602-3490

pISSN:

2602-3490

Abstract:

 

Endotoxemia causes many pathophysiological changes in the body. These changes may alter the
pharmacokinetics of antibacterial agents used in the treatment. Purpose of this research; a) to determine the
effect of the pharmacokinetics of marbofloxacin in the healthy sheep, b) to determine the effect of
endotoxemia treatment (ET) on the pharmacokinetics of marbofloxacin in the healthy sheep, c) to
determine the pharmacokinetics of marbofloxacin in the experimentally induced endotoxemic (LPS, E.
coli O55:B5) sheep treated with ET. Seven clinically healthy Merino sheep were used. The study was
carried out according to a 3-cycle cross-pharmacokinetic design and a 15-day wash-out period was
performed between the stages. In the study, respectively, marbofloxacin (MB) 10 mg/kg (IV), MB + ET
(lactated ringer + Dextrose 5% + sodium chloride 0.45% 20 mL/kg, IV, 20 ml/kg/h, dexamethasone 0.5
mg/kg, SC) and LPS (10 μg/kg IV infusion for 30 minutes) followed by MB + ET were administered. In
all phases of the study, blood samples were collected before (0 hours, control) and after MB administration
at 0.083, 0.167, 0.25, 0.333, 0.417, 0.5, 0.75, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 18, 24, 36, 48, 72 and 96 h.
Plasma MB concentration was measured using high performance liquid chromatography-UV and noncompartmental
pharmacokinetic parameters were calculated. When the MB + ET group was compared
with the MB group, no difference was found (P>0.05) in the basic pharmacokinetic parameters
(t1/2λz , MRT, AUC0-∞, ClT and Vdss). When the LPS +MB + ET group was compared with the other
two groups, it was found that t1/2λz and MRT were prolonged, AUC0-∞ increased and ClT decreased
(P<0.05). In conclusion, it may be stated that endotoxemia may change pharmacokinetic values of
marbofloxacin.

Article Details

Determination of the pharmacokinetics of marbofloxacin in endotoxemic sheep

Authors: Devran COŞKUN | Orhan ÇORUM | Enver YAZAR

Publisher: The Chamber of Veterinary Surgeons, Istanbul

Main Topics: Animal husbandry

Journal: Journal of Istanbul Veterinary Sciences 2020, pp.42-42

Document Type: Article

Publication Date: 3/2020

Document Language: English

Document ID (Org No.): 2000485277

Frequency: Tri-annual

eISSN: 2602-3490

pISSN: 2602-3490

Issues

Authors:

Devran COŞKUN | Orhan ÇORUM | Enver YAZAR

Publisher:

The Chamber of Veterinary Surgeons, Istanbul

Main Topics:

Animal husbandry

Journal:

Journal of Istanbul Veterinary Sciences 2020, pp.42-42

Document Type:

Article

Publication Date:

3/2020

Document Language:

English

Document ID (Org No.):

2000485277

Frequency:

Tri-annual

eISSN:

2602-3490

pISSN:

2602-3490