A VALIDATED ADSORPTIVE STRIPPING DIFFERENTIAL PULSE VOLTAMMETRIC METHOD FOR THE QUANTIFICATION OF LINAGLIPTIN FROM URINE SAMPLE

Ali Kemal Ateş

Article Details

A VALIDATED ADSORPTIVE STRIPPING DIFFERENTIAL PULSE VOLTAMMETRIC METHOD FOR THE QUANTIFICATION OF LINAGLIPTIN FROM URINE SAMPLE

Authors:

Ali Kemal Ateş

Publisher:

Ankara University

Main Topics:

Eczacılıkta Analitik Kimya

Journal:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 3, pp.809-816

Document Type:

Article

Publication Date:

9/2025

Document Language:

English

Document ID (Org No.):

2001356418

pISSN:

1015-3918

Keywords:

Abstract:

 Objective: In this study, a low-cost, sensitive and practical electroanalytical method was developed and validated for the determination of Linagliptin LNG, a therapeutic agent used in the treatment of Diabetes Mellitus, one of the most common chronic diseases worldwide, characterized by high blood glucose levels and directly affecting millions of people. Material and Method: Electroanalytical studies were completed using screen-printed carbon electrodes in pH: 8 Britton - Robinson buffer solution. Mechanistic studies were carried out by cyclic voltammetry technique. Adsorptive stripping differential pulse voltammetry technique was used for the electrochemical determination of LNG. Result and Discussion: The developed method exhibited linearity in the range of 0.1 - 7.5 µM and the limit of detection value was calculated as 37 nM. The developed method was applied for the determination of LNG from urine and a recovery value of 100.02 was obtained.

 Objective: In this study, a low-cost, sensitive and practical electroanalytical method was developed and validated for the determination of Linagliptin LNG, a therapeutic agent used in the treatment of Diabetes Mellitus, one of the most common chronic diseases worldwide, characterized by high blood glucose levels and directly affecting millions of people. Material and Method: Electroanalytical studies were completed using screen-printed carbon electrodes in pH: 8 Britton - Robinson buffer solution. Mechanistic studies were carried out by cyclic voltammetry technique. Adsorptive stripping differential pulse voltammetry technique was used for the electrochemical determination of LNG. Result and Discussion: The developed method exhibited linearity in the range of 0.1 - 7.5 µM and the limit of detection value was calculated as 37 nM. The developed method was applied for the determination of LNG from urine and a recovery value of 100.02 was obtained.

 Objective: In this study, a low-cost, sensitive and practical electroanalytical method was developed and validated for the determination of Linagliptin LNG, a therapeutic agent used in the treatment of Diabetes Mellitus, one of the most common chronic diseases worldwide, characterized by high blood glucose levels and directly affecting millions of people. Material and Method: Electroanalytical studies were completed using screen-printed carbon electrodes in pH: 8 Britton - Robinson buffer solution. Mechanistic studies were carried out by cyclic voltammetry technique. Adsorptive stripping differential pulse voltammetry technique was used for the electrochemical determination of LNG. Result and Discussion: The developed method exhibited linearity in the range of 0.1 - 7.5 µM and the limit of detection value was calculated as 37 nM. The developed method was applied for the determination of LNG from urine and a recovery value of 100.02 was obtained.

 Amaç: Bu çalışmada, dünya çapında en yaygın kronik hastalıklardan biri olan, yüksek kan şekeri ile karakterize, ve milyonlarca insanı doğrudan etkileyen bir rahatsızlık olan Diabetes Mellitus tedavisinde kullanılan terapötik bir ajan olan Linagliptin LNG tayini için düşük maliyetli, hassas ve pratik bir elektroanalitik yöntem geliştirilmiş ve valide edilmiştir. Gereç ve Yöntem: Elektroanalitik çalışmalar pH: 8 Britton - Robinson tampon çözelti ortamında perde baskılı carbon elektrotlar kullanılarak tamamlanmıştır. Mekanistik çalışmalar dönüşümlü voltametri tekniği ile yapılmıştır. LNGnin elektrokimyasal tayini için de adsorptif sıyırma diferansiyel puls voltametri tekniği kullanılmıştır. Sonuç ve Tartışma: Geliştirilen yöntem 0.1  7.5 µM aralığında doğrusallık sergilemiş ve gözlenebilme sınırı 37 nM olarak hesaplanmıştır. Geliştirilen yöntem idrardan LNG tayini için uygulanmış ve  100.02lik bir geri kazanım değeri elde edilmiştir.

Article Details

A VALIDATED ADSORPTIVE STRIPPING DIFFERENTIAL PULSE VOLTAMMETRIC METHOD FOR THE QUANTIFICATION OF LINAGLIPTIN FROM URINE SAMPLE

Authors:

Ali Kemal Ateş

Publisher:

Ankara University

Main Topics:

Eczacılıkta Analitik Kimya

Journal:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 3, pp.809-816

Document Type:

Article

Publication Date:

9/2025

Document Language:

English

Document ID (Org No.):

2001356418

pISSN:

1015-3918

Adsorptive stripping differential pulse voltammetry

antidiabetic drug

electrochemical determination

linagliptinAdsorptive sıyırma diferansiyel puls voltametri

antidiyabetik ilaç

elektrokimyasal analiz

linagliptin

Issues

Article Details

Authors: Ali Kemal Ateş

Publisher: Ankara University

Main Topics: Eczacılıkta Analitik Kimya

Journal: Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 3, pp.809-816

Document Type: Article

Publication Date: 9/2025

Document Language: English

Document ID (Org No.): 2001356418

pISSN: 1015-3918

Issues

Authors:

Ali Kemal Ateş

Publisher:

Ankara University

Main Topics:

Eczacılıkta Analitik Kimya

Journal:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 3, pp.809-816

Document Type:

Article

Publication Date:

9/2025

Document Language:

English

Document ID (Org No.):

2001356418

pISSN:

1015-3918