Synthesis, Characterization and in Vitro Degradation of Poly(DL-Lactide)/Poly(DL-Lactide-co-Glycolide) Films

Menemşe KİREMİTÇİ-GÜMÜŞDERELİOĞLU; Günday DENİZ

Article Details

Synthesis, Characterization and in Vitro Degradation of Poly(DL-Lactide)/Poly(DL-Lactide-co-Glycolide) Films

Authors:

Menemşe KİREMİTÇİ-GÜMÜŞDERELİOĞLU | Günday DENİZ

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 1999 Vol.23 Issue 2, pp.153-162

Document Type:

Article

Publication Date:

1/1999

Document Language:

Turkish

Document ID (Org No.):

2000730442

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

Abstract:

 

Poly(dl-lactide) (PLA) homopolymers and  poly(dl-lactide-co-glycolide) (PLGA) copolymers were synthesized from  their cyclic dimers, i.e. dl-lactide and glycolide, by ring-opening  polymerization in the presence of catalyst stannous octoate and chain  control agent lauryl alcohol.  The effects of catalyst and chain  control agent concentrations, reaction temperature, and reaction time  on the molecular weight and yield of homopolymers were studied.  The  homopolymers were obtained in the intrinsic viscosity 0.1 to 1.0 dl/g  range by changing the polymerization conditions.  The copolymers in  two different lactide/glycolide ratios, i.e. 90:10 and 70:30 and in  0.60 intrinsic viscosity were synthesized.  The polymers were further  characterized by IR, 1H-NMR, 13C-NMR, and DSC. In vitro  degradation studies were conducted at 37°C in pH 7.4 phosphate  buffered saline.  The results showed that the intrinsic viscosities of  all polymers decrease continuously until 0.20 dl/g after exposure to  phosphate buffered saline and then a very sharp mass loss occurs.

 

Poly(dl-lactide) (PLA) homopolymers and  poly(dl-lactide-co-glycolide) (PLGA) copolymers were synthesized from  their cyclic dimers, i.e. dl-lactide and glycolide, by ring-opening  polymerization in the presence of catalyst stannous octoate and chain  control agent lauryl alcohol.  The effects of catalyst and chain  control agent concentrations, reaction temperature, and reaction time  on the molecular weight and yield of homopolymers were studied.  The  homopolymers were obtained in the intrinsic viscosity 0.1 to 1.0 dl/g  range by changing the polymerization conditions.  The copolymers in  two different lactide/glycolide ratios, i.e. 90:10 and 70:30 and in  0.60 intrinsic viscosity were synthesized.  The polymers were further  characterized by IR, 1H-NMR, 13C-NMR, and DSC. In vitro  degradation studies were conducted at 37°C in pH 7.4 phosphate  buffered saline.  The results showed that the intrinsic viscosities of  all polymers decrease continuously until 0.20 dl/g after exposure to  phosphate buffered saline and then a very sharp mass loss occurs.

Article Details

Synthesis, Characterization and in Vitro Degradation of Poly(DL-Lactide)/Poly(DL-Lactide-co-Glycolide) Films

Authors: Menemşe KİREMİTÇİ-GÜMÜŞDERELİOĞLU | Günday DENİZ

Publisher: TUBITAK

Journal: Turkish Journal of Chemistry 1999 Vol.23 Issue 2, pp.153-162

Document Type: Article

Publication Date: 1/1999

Document Language: Turkish

Document ID (Org No.): 2000730442

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

Issues

Authors:

Menemşe KİREMİTÇİ-GÜMÜŞDERELİOĞLU | Günday DENİZ

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 1999 Vol.23 Issue 2, pp.153-162

Document Type:

Article

Publication Date:

1/1999

Document Language:

Turkish

Document ID (Org No.):

2000730442

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527