Durability of Sustained Virological Response and Long Term Follow Up to Pegylated Interferon and Ribavirin in Treated Patients with Chronic Hepatitis C

Waseem Hamoudi; Sami Al-Smadi; Karim Lutfi; Moath Azizi; Yousef Niomat

doi:10.12816/0004535

Article Details

Durability of Sustained Virological Response and Long Term Follow Up to Pegylated Interferon and Ribavirin in Treated Patients with Chronic Hepatitis C

Authors:

Waseem Hamoudi | Sami Al-Smadi | Karim Lutfi | Moath Azizi | Yousef Niomat

Publisher:

Jordanian Medical services - Jordanian Armed Forces

Main Topics:

Medicine

Journal:

Journal of the Royal Medical Services 2014 vol.21 Issue 2, pp.6-12

Document Type:

Article

Publication Date:

6/2014

Document Language:

English

Document ID (Org No.):

47306

Frequency:

Quarterly

eISSN:

20788711

pISSN:

20788703

DOI:

10.12816/0004535

Descriptors:

Keywords:

Abstract:

 Objective: To study the clinical, biochemical and virological long-term outcome in chronic hepatitis C patients with a Sustained Virological Response after Pegylated Interferon plus ribavirin combination therapy.
Methods: Twenty eight patients with a Sustained Virological Response after treatment with Pegylated Interferon plus ribavirin were included in a 5-year follow-up study in a single Gastroenterology & Hepatology center, based on standard clinical practice. Clinical and ultrasonic evaluation, liver function tests, alpha-fetoprotein and hepatitis C virus RNA by PCR were performed annually for a period of 5 years.
Results: The mean follow-up period of the 28 patients was 67 ± 4 months after they obtained a sustained virological response. Eleven patients (39.2%) presented with high fibrosis score (Metavir >3) before treatment. Seventeen patients (60.7%) had genotype 4, nine patients (32.1%) genotype 1, one patient genotype 2 and one patient genotype 3. One patient (3.5%) showed evidence of hepatic decompensation. One patient (3.5%) showed virological relapse after achieving sustained virological response. At the end of the 5-year follow-up there were no deaths, no elevation in liver function tests and no hepatocellular carcinoma.
Conclusion: The long-term outcome of patients with sustained virological response to Pegylated Interferon plus ribavirin was maintained in 96.5% with one patient having virological relapse, indicating that Long term recurrence rate to combination therapy was very low.

Article Details

Durability of Sustained Virological Response and Long Term Follow Up to Pegylated Interferon and Ribavirin in Treated Patients with Chronic Hepatitis C

Authors:

Waseem Hamoudi | Sami Al-Smadi | Karim Lutfi | Moath Azizi | Yousef Niomat

Publisher:

Jordanian Medical services - Jordanian Armed Forces

Main Topics:

Medicine

Journal:

Journal of the Royal Medical Services 2014 vol.21 Issue 2, pp.6-12

Document Type:

Article

Publication Date:

6/2014

Document Language:

English

Document ID (Org No.):

47306

Frequency:

Quarterly

eISSN:

20788711

pISSN:

20788703

DOI:

10.12816/0004535

Descriptors:

LIVER DISEASES

INTERFERON

BIOCHEMISTRY

VIROSES

PATIENTS

THERAPY

Chronic Hepatitis C

Pegylated Interferon

Ribavirin

Sustained Virological Response

Viral Genotype

Issues

Article Details

Authors: Waseem Hamoudi | Sami Al-Smadi | Karim Lutfi | Moath Azizi | Yousef Niomat

Publisher: Jordanian Medical services - Jordanian Armed Forces

Main Topics: Medicine

Journal: Journal of the Royal Medical Services 2014 vol.21 Issue 2, pp.6-12

Document Type: Article

Publication Date: 6/2014

Document Language: English

Document ID (Org No.): 47306

Frequency: Quarterly

eISSN: 20788711

pISSN: 20788703

DOI: 10.12816/0004535

Descriptors:

Issues

Authors:

Waseem Hamoudi | Sami Al-Smadi | Karim Lutfi | Moath Azizi | Yousef Niomat

Publisher:

Jordanian Medical services - Jordanian Armed Forces

Main Topics:

Medicine

Journal:

Journal of the Royal Medical Services 2014 vol.21 Issue 2, pp.6-12

Document Type:

Article

Publication Date:

6/2014

Document Language:

English

Document ID (Org No.):

47306

Frequency:

Quarterly

eISSN:

20788711

pISSN:

20788703

DOI:

10.12816/0004535