Investigation of Regeneration Capacity in Rat Liver After Hepatic Resection

Şamil ÖZTÜRK; Latife Ceyda İRKİN; İlhan ÖZDEMİR

Article Details

Investigation of Regeneration Capacity in Rat Liver After Hepatic Resection

Authors:

Şamil ÖZTÜRK | Latife Ceyda İRKİN | İlhan ÖZDEMİR

Publisher:

Ekoloji ve Ekotoksikoloji Derneği

Main Topics:

Life sciences

Journal:

Environmental Toxicology and Ecology 2021 Vol.1 Issue 1, pp.27-32

Document Type:

Article

Publication Date:

4/2021

Document Language:

English

Document ID (Org No.):

2000776230

Frequency:

Bi-Annual

eISSN:

2757-9719

Keywords:

Abstract:

 

The liver is the largest gland of the body that secretes both endocrine and exocrine secretions and plays a major role in the regulation of metabolic functions. Numerous factors such as drugs, chemicals, accidents, alcohol, surgical procedures can cause damage to the liver tissue. In this study, we aimed to determine the regeneration capacity of liver tissue in order to recover the mass loss after hepatic resection.
In our experiment 21 Wistar albino male rats were used. All experimental groups applied midline incision with laparotomy for resection of liver. At the end of 1 and 7th days, liver tissue removed for light microscopic analysis. The rats were divided three groups: Control, group 1: hepatectomy one day after liver resection, group 2: hepatectomy seven days after liver resection.
The tissue of all experimental groups were showed some histopatological changes such as sinuzoidal dilatation, vacuolization in the hepatocytes. These histopathological differentiation was found to be severe in group II compared to other groups. At the end of the 7th day, it was observed that the regeneration increased significantly, and the mitotic index value reached almost the maximum level in the second group. It was observed that the mitotic index value gradually decreased in group I and reached values close to the control group.

 


The liver is the largest gland of the body that secretes both endocrine and exocrine secretions and plays a major role in the regulation of metabolic functions. Numerous factors such as drugs, chemicals, accidents, alcohol, surgical procedures can cause damage to the liver tissue. In this study, we aimed to determine the regeneration capacity of liver tissue in order to recover the mass loss after hepatic resection. In our experiment 21 Wistar albino male rats were used. All experimental groups applied midline incision with laparotomy for resection of liver. At the end of 1 and 7th days, liver tissue removed for light microscopic analysis. The rats were divided three groups: Control, group 1: hepatectomy one day after liver resection, group 2: hepatectomy seven days after liver resection. The tissue of all experimental groups were showed some histopatological changes such as sinuzoidal dilatation, vacuolization in the hepatocytes. These histopathological differentiation was found to be severe in group II compared to other groups. At the end of the 7th day, it was observed that the regeneration increased significantly, and the mitotic index value reached almost the maximum level in the second group. It was observed that the mitotic index value gradually decreased in group I and reached values close to the control group.

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Article Details

Investigation of Regeneration Capacity in Rat Liver After Hepatic Resection

Authors:

Şamil ÖZTÜRK | Latife Ceyda İRKİN | İlhan ÖZDEMİR

Publisher:

Ekoloji ve Ekotoksikoloji Derneği

Main Topics:

Life sciences

Journal:

Environmental Toxicology and Ecology 2021 Vol.1 Issue 1, pp.27-32

Document Type:

Article

Publication Date:

4/2021

Document Language:

English

Document ID (Org No.):

2000776230

Frequency:

Bi-Annual

eISSN:

2757-9719

Hepatectomy

Regeneration

Liver

Mitosis

Issues

Article Details

Investigation of Regeneration Capacity in Rat Liver After Hepatic Resection

Authors: Şamil ÖZTÜRK | Latife Ceyda İRKİN | İlhan ÖZDEMİR

Publisher: Ekoloji ve Ekotoksikoloji Derneği

Main Topics: Life sciences

Journal: Environmental Toxicology and Ecology 2021 Vol.1 Issue 1, pp.27-32

Document Type: Article

Publication Date: 4/2021

Document Language: English

Document ID (Org No.): 2000776230

Frequency: Bi-Annual

eISSN: 2757-9719

Hepatectomy

Regeneration

Liver

Mitosis

Issues

Authors:

Şamil ÖZTÜRK | Latife Ceyda İRKİN | İlhan ÖZDEMİR

Publisher:

Ekoloji ve Ekotoksikoloji Derneği

Main Topics:

Life sciences

Journal:

Environmental Toxicology and Ecology 2021 Vol.1 Issue 1, pp.27-32

Document Type:

Article

Publication Date:

4/2021

Document Language:

English

Document ID (Org No.):

2000776230

Frequency:

Bi-Annual

eISSN:

2757-9719