Protective Role of Naringenin on Oxidative Stress Caused by Fenamiphos in Rat Blood and Spleen Tissue

Hatice Karaboduk; Çağlar Adıgüzel; Fatma Gökçe Apaydın; Suna Kalender; Meltem Uzunhisarcikli; Yusuf Kalender

Article Details

Protective Role of Naringenin on Oxidative Stress Caused by Fenamiphos in Rat Blood and Spleen Tissue

Authors:

Hatice Karaboduk | Çağlar Adıgüzel | Fatma Gökçe Apaydın | Suna Kalender | Meltem Uzunhisarcikli | Yusuf Kalender

Publisher:

Igdir University

Main Topics:

Hayvan Bilimi (Diğer)

Journal:

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.14 Issue 2, pp.625-635

Document Type:

Article

Publication Date:

1/2024

Document Language:

Turkish

Document ID (Org No.):

2001317798

pISSN:

2536-4618

Keywords:

Abstract:

 Fenamiphos, an organophosphate insecticide, is frequently used in agricultural areas and causes various problems in terms of environment and public health. Naringenin is a flavonone with anticancer, anti-inflammatory, antioxidant and antiproliferative activities. The aim of this study is to investigate the protective role of naringenin on fenamiphos-induced oxidative stress in the blood and spleen tissue of rats. In this study, rats were divided into 4 groups, with 6 in each group. 1st group: control group, 2nd group: fenamifos 0.76 mgkg b.w. treated group, 3rd group: naringenin 50 mgkg b.w. treated group 4th group: fenamifos 0.76 mgkg b.w. v.a. plus naringenin 50 mgkg b.a. treated group. The substances were given to experimental animals via gavage for 28 days. When the fenamiphos treated group was compared with the control group, a statistically significant increase was observed in MDA, IL-17 and 8-OHdG levels compared to the control group p 0.05, while a statistically significant decrease was observed in SOD, CAT, GPx and GST enzyme activities p0.05. When the naringenin-treated group was compared with the fenamiphos-treated group, a significant improvement in the parameters was observed. In this study, it was observed that the administration of naringenin, which has strong antioxidant properties, significantly reduced oxidative damage against the toxicity caused by fenamiphos in the blood and spleen tissue of rats.

 Fenamiphos, an organophosphate insecticide, is frequently used in agricultural areas and causes various problems in terms of environment and public health. Naringenin is a flavonone with anticancer, anti-inflammatory, antioxidant and antiproliferative activities. The aim of this study is to investigate the protective role of naringenin on fenamiphos-induced oxidative stress in the blood and spleen tissue of rats. In this study, rats were divided into 4 groups, with 6 in each group. 1st group: control group, 2nd group: fenamifos 0.76 mgkg b.w. treated group, 3rd group: naringenin 50 mgkg b.w. treated group 4th group: fenamifos 0.76 mgkg b.w. v.a. plus naringenin 50 mgkg b.a. treated group. The substances were given to experimental animals via gavage for 28 days. When the fenamiphos treated group was compared with the control group, a statistically significant increase was observed in MDA, IL-17 and 8-OHdG levels compared to the control group p 0.05, while a statistically significant decrease was observed in SOD, CAT, GPx and GST enzyme activities p0.05. When the naringenin-treated group was compared with the fenamiphos-treated group, a significant improvement in the parameters was observed. In this study, it was observed that the administration of naringenin, which has strong antioxidant properties, significantly reduced oxidative damage against the toxicity caused by fenamiphos in the blood and spleen tissue of rats.

 Fenamiphos, an organophosphate insecticide, is frequently used in agricultural areas and causes various problems in terms of environment and public health. Naringenin is a flavonone with anticancer, anti-inflammatory, antioxidant and antiproliferative activities. The aim of this study is to investigate the protective role of naringenin on fenamiphos-induced oxidative stress in the blood and spleen tissue of rats. In this study, rats were divided into 4 groups, with 6 in each group. 1st group: control group, 2nd group: fenamifos 0.76 mgkg b.w. treated group, 3rd group: naringenin 50 mgkg b.w. treated group 4th group: fenamifos 0.76 mgkg b.w. v.a. plus naringenin 50 mgkg b.a. treated group. The substances were given to experimental animals via gavage for 28 days. When the fenamiphos treated group was compared with the control group, a statistically significant increase was observed in MDA, IL-17 and 8-OHdG levels compared to the control group p 0.05, while a statistically significant decrease was observed in SOD, CAT, GPx and GST enzyme activities p0.05. When the naringenin-treated group was compared with the fenamiphos-treated group, a significant improvement in the parameters was observed. In this study, it was observed that the administration of naringenin, which has strong antioxidant properties, significantly reduced oxidative damage against the toxicity caused by fenamiphos in the blood and spleen tissue of rats.

 Organofosfatlı bir insektisit olan fenamifos, tarım alanlarında sıklıkla kullanılmakta, çevre ve halk sağlığı açısından çeşitli sorunlar meydana getirmektedir. Naringenin, antikanser, antiinflamatuvar, antioksidan ve antiproliferatif aktivitelere sahip bir flavonondur. Bu çalışmanın amacı sıçanların kan ve dalak dokusunda fenamifos kaynaklı oksidatif stres üzerine naringeninin koruyucu rolünü araştırmaktır. Bu çalışmada sıçanlar her grupta 6 adet olacak şekilde 4 gruba ayrılmıştır. 1. grup: kontrol grubu, 2. grup: fenamifos 0.76 mgkg v.a. muameleli grup, 3. grup: naringenin 50 mgkg v.a. muameleli grup 4. grup: fenamifos 0.76 mgkg v.a. ve naringenin 50 mgkg v.a. muameleli grup. Maddeler deney hayvanlarına 28 gün boyunca gavaj yolu ile verilmiştir. Fenamifos muameleli grup, kontrol grubu ile karşılaştırıldığında MDA, IL-17 ve 8-OHdG düzeylerinde kontrol grubuna göre istatistiksel olarak anlamlı bir artış gözlenirken p0.05, SOD, CAT, GPx ve GST enzim aktivitelerinde ise istatiksel olarak anlamlı bir azalma gözlenmiştir p0.05. Naringenin muameleli grup, fenamifos muameleli grup ile karşılaştırıldığında, parametrelerde anlamlı bir iyileşme gözlenmiştir. Bu çalışmada fenamifosun sıçanların kan ve dalak dokusunda oluşturduğu toksisiteye karşı, antioksidan özellikleri güçlü naringenin uygulamasının oksidatif hasarı önemli ölçüde azalttığı gözlenmiştir.

Article Details

Protective Role of Naringenin on Oxidative Stress Caused by Fenamiphos in Rat Blood and Spleen Tissue

Authors:

Hatice Karaboduk | Çağlar Adıgüzel | Fatma Gökçe Apaydın | Suna Kalender | Meltem Uzunhisarcikli | Yusuf Kalender

Publisher:

Igdir University

Main Topics:

Hayvan Bilimi (Diğer)

Journal:

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.14 Issue 2, pp.625-635

Document Type:

Article

Publication Date:

1/2024

Document Language:

Turkish

Document ID (Org No.):

2001317798

pISSN:

2536-4618

Blood

Spleen

Fenamiphos

Naringenin

Oxidative stressKan

Dalak

Fenamifos

Naringenin

Oksidatif stres

Issues

Article Details

Authors: Hatice Karaboduk | Çağlar Adıgüzel | Fatma Gökçe Apaydın | Suna Kalender | Meltem Uzunhisarcikli | Yusuf Kalender

Publisher: Igdir University

Main Topics: Hayvan Bilimi (Diğer)

Journal: Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.14 Issue 2, pp.625-635

Document Type: Article

Publication Date: 1/2024

Document Language: Turkish

Document ID (Org No.): 2001317798

pISSN: 2536-4618

Issues

Authors:

Hatice Karaboduk | Çağlar Adıgüzel | Fatma Gökçe Apaydın | Suna Kalender | Meltem Uzunhisarcikli | Yusuf Kalender

Publisher:

Igdir University

Main Topics:

Hayvan Bilimi (Diğer)

Journal:

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.14 Issue 2, pp.625-635

Document Type:

Article

Publication Date:

1/2024

Document Language:

Turkish

Document ID (Org No.):

2001317798

pISSN:

2536-4618