Muscarinic M1 and M2 receptors, fasting and seizure development in animals

Merve SAYGI BACANAK

Article Details

Muscarinic M1 and M2 receptors, fasting and seizure development in animals

Authors:

Merve SAYGI BACANAK

Publisher:

Marmara University

Journal:

Clinical and Experimental Health Sciences 2018 Vol.8 Issue 4, pp.308-313

Document Type:

Article

Publication Date:

12/2018

Document Language:

English

Document ID (Org No.):

2000907143

Frequency:

Monthly

eISSN:

2459-1459

Abstract:

 


Muscarinic M1 and M2 receptors are widely distributed in the brain and contribute to

various physiological and pathological functions. It is well known that enhancement of

cholinergic activity produces convulsions in animals. Pilocarpine, the M1 muscarinic

receptor agonist, is commonly used to induce seizures in rodents. On the other hand

it has been reported that fasted rats and mice pretreated with the M1 and M2 receptor

antagonist atropine, scopolamine or biperiden develop convulsions after food intake

indicating cholinergic hypoactivity as the underlying mechanism. This review will

present pharmacological data for the M1 and M2 receptors in the brain and focus on

the contrasting findings related to their contribution to convulsions.

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Article Details

Muscarinic M1 and M2 receptors, fasting and seizure development in animals

Authors: Merve SAYGI BACANAK

Publisher: Marmara University

Journal: Clinical and Experimental Health Sciences 2018 Vol.8 Issue 4, pp.308-313

Document Type: Article

Publication Date: 12/2018

Document Language: English

Document ID (Org No.): 2000907143

Frequency: Monthly

eISSN: 2459-1459

Issues

Authors:

Merve SAYGI BACANAK

Publisher:

Marmara University

Journal:

Clinical and Experimental Health Sciences 2018 Vol.8 Issue 4, pp.308-313

Document Type:

Article

Publication Date:

12/2018

Document Language:

English

Document ID (Org No.):

2000907143

Frequency:

Monthly

eISSN:

2459-1459