Spectrophotometric method enhanced by cloud point extraction for the determination of Levofloxacin in pharmaceutical preparations

Talal Abdullah Atawe; Shahla Jamal Shakkor

Article Details

Spectrophotometric method enhanced by cloud point extraction for the determination of Levofloxacin in pharmaceutical preparations

Authors:

Talal Abdullah Atawe | Shahla Jamal Shakkor

Publisher:

University of Kirkuk

Journal:

Kirkuk Journal of Science Vol.21 Issue 2, pp.53-63

Document Type:

Article

Publication Date:

1/2026

Document Language:

English

Document ID (Org No.):

2001932273

pISSN:

3005-4788

Keywords:

Abstract:

 This study presents a simple and accurate analytical determination of the quantity of certain anti-inflammatory drugs of the fluoroquinolone class, specifically Levofloxacin, in its pure form and in pharmaceutical preparations. This study uses the cloud point extraction method, which is the reaction of the drug with namely Ferric (III) ions in FeCl3 salt, in the presence of the active surface Triton X-114. The used method showed excellent linearity in the range of 5-45 μg/ml at a wavelength of 386 nm, with high accuracy and sensitivity. This is evident from the limit of detection (LOD) of 1.346 μg/ml and the limit of quantification (LOQ) of 4.055 μg/ml. The application of this method to commercial tablet formulations and intravenous injections resulted in high recovery rates RSD%.

Article Details

Spectrophotometric method enhanced by cloud point extraction for the determination of Levofloxacin in pharmaceutical preparations

Authors:

Talal Abdullah Atawe | Shahla Jamal Shakkor

Publisher:

University of Kirkuk

Journal:

Kirkuk Journal of Science Vol.21 Issue 2, pp.53-63

Document Type:

Article

Publication Date:

1/2026

Document Language:

English

Document ID (Org No.):

2001932273

pISSN:

3005-4788

Levofloxacin

cloud point extraction

spectrophotometer

FeCl

Triton X-114

Issues

Article Details

Spectrophotometric method enhanced by cloud point extraction for the determination of Levofloxacin in pharmaceutical preparations

Authors: Talal Abdullah Atawe | Shahla Jamal Shakkor

Publisher: University of Kirkuk

Journal: Kirkuk Journal of Science Vol.21 Issue 2, pp.53-63

Document Type: Article

Publication Date: 1/2026

Document Language: English

Document ID (Org No.): 2001932273

pISSN: 3005-4788

Levofloxacin

cloud point extraction

spectrophotometer

FeCl

Triton X-114

Issues

Authors:

Talal Abdullah Atawe | Shahla Jamal Shakkor

Publisher:

University of Kirkuk

Journal:

Kirkuk Journal of Science Vol.21 Issue 2, pp.53-63

Document Type:

Article

Publication Date:

1/2026

Document Language:

English

Document ID (Org No.):

2001932273

pISSN:

3005-4788