Comparison Between the Effect of Antimlarial Drug Produced by Local

Mohammed Abdul-Aziz Kadir; Nuria Abdul-Hussein; Ayhan Rashid Mahmoud

Article Details

Comparison Between the Effect of Antimlarial Drug Produced by Local

Authors:

Mohammed Abdul-Aziz Kadir | Nuria Abdul-Hussein | Ayhan Rashid Mahmoud

Publisher:

University of Kirkuk

Journal:

Kirkuk Journal of Science Vol.9 Issue 1, pp.1-10

Document Type:

Article

Publication Date:

6/2014

Document Language:

English

Document ID (Org No.):

2001931683

pISSN:

3005-4788

Keywords:

Abstract:

 Local isolate of Streptomyces sp.1 showed ability to produce antimalarial activity against P.vivax, it
caused a great reduction in the number of the parasite. The inhibition percentages during 24 and 48 hours
were 60.90, 88.38 respectively. Purification of antimalarial agent produced by Streptomyces sp.1 was done
by extraction with ethylacetate followed by methanol, and application of gel filtration (Sephadex LH-20,
Silica gel column) which resulted in brownish compound. This compound named as SAN 1.
Drug, antibiotics and SAN1 inhibited the growth of P. vivax in vitro. The highest inhibition value (87.55%)
was observed when 1000  g/ml of trimethoprim was added to cultural medium, followed by chloroquine,
primaquine, chloramphenicol, tetracycline, streptomycin, SAN1, rifamycin, erythromycin, ampicillin with
inhibition percent 86.09, 83.81, 81.74, 78.83, 78.66, 78.42, 75.10, 74.27 and 74.06% respectively.

Article Details

Comparison Between the Effect of Antimlarial Drug Produced by Local

Authors:

Mohammed Abdul-Aziz Kadir | Nuria Abdul-Hussein | Ayhan Rashid Mahmoud

Publisher:

University of Kirkuk

Journal:

Kirkuk Journal of Science Vol.9 Issue 1, pp.1-10

Document Type:

Article

Publication Date:

6/2014

Document Language:

English

Document ID (Org No.):

2001931683

pISSN:

3005-4788

chemical drugs

Streptomyces

vivax

Issues

Article Details

Comparison Between the Effect of Antimlarial Drug Produced by Local

Authors: Mohammed Abdul-Aziz Kadir | Nuria Abdul-Hussein | Ayhan Rashid Mahmoud

Publisher: University of Kirkuk

Journal: Kirkuk Journal of Science Vol.9 Issue 1, pp.1-10

Document Type: Article

Publication Date: 6/2014

Document Language: English

Document ID (Org No.): 2001931683

pISSN: 3005-4788

chemical drugs

Streptomyces

vivax

Issues

Authors:

Mohammed Abdul-Aziz Kadir | Nuria Abdul-Hussein | Ayhan Rashid Mahmoud

Publisher:

University of Kirkuk

Journal:

Kirkuk Journal of Science Vol.9 Issue 1, pp.1-10

Document Type:

Article

Publication Date:

6/2014

Document Language:

English

Document ID (Org No.):

2001931683

pISSN:

3005-4788