Gene therapy in sports medicine

Christian Latermann; Semih Gur; Paul Robbins; Christopher Evans

Article Details

Gene therapy in sports medicine

Authors:

Christian Latermann | Semih Gur | Paul Robbins | Christopher Evans

Publisher:

Turkish Association of Orthopaedics and Traumatology

Journal:

Acta Orthopaedica et Traumatologica Turcica 1997 Vol.31 Issue 5, pp.502-505

Document Type:

Article

Publication Date:

9/2006

Document Language:

English

Document ID (Org No.):

2000814171

Frequency:

Bimonthly

eISSN:

1017-995X

pISSN:

1017-995X

Keywords:

-

Abstract:

 

Injured soft tissues trigger a cellular response which is necessary for recovery and regulated by specific proteins, namely growth factors like PDGF, TGF-B, BFGF, IGF-1 and BMP-2. Application of these factors via external  route is not possible because of the very short half-life time. Thus, gene therapy with virus vectors is now being discussed to provide continuous growth factors. As briefly summarized in this review article experiments on animals and early results of clinical work and research demonstrate that it can be used in the treatment of sports injuries.

 

Yaralanmaya uğrayan yumuşak dokunun iyileşmesi için gerekli hücresel yanıtların herbirisi PDGF, TGF-B, bFGF, IGF-I, BMP-2 gibi. "growth factor" diye adlandırılan spesifik proteinler tarafından kontrol edilirler. Dışarıdan uygulanabilen bu faktörlerin yenilenme ömrü son derece kısa olduğu için viral taşıyıcı-larla, gen tedavisi gündeme gelmiştir. Gen tedavisinin en büyük etkinliği potansiyel olarak etkilenen dokulara sürekli growth faktör taşıyıcılarının verilmesidir. Bu derleme ile özetlendiği üzere hayvanlar üzerinde ya-pılan çalışmalar ve insan araştırmalarının ilk klinik sonuçları bu tekniğin spor yaralanmalarının tedavisinde kullanılabileceğini ortaya koymaktadır.

Article Details

Gene therapy in sports medicine

Authors: Christian Latermann | Semih Gur | Paul Robbins | Christopher Evans

Publisher: Turkish Association of Orthopaedics and Traumatology

Journal: Acta Orthopaedica et Traumatologica Turcica 1997 Vol.31 Issue 5, pp.502-505

Document Type: Article

Publication Date: 9/2006

Document Language: English

Document ID (Org No.): 2000814171

Frequency: Bimonthly

eISSN: 1017-995X

pISSN: 1017-995X

-

Issues

Authors:

Christian Latermann | Semih Gur | Paul Robbins | Christopher Evans

Publisher:

Turkish Association of Orthopaedics and Traumatology

Journal:

Acta Orthopaedica et Traumatologica Turcica 1997 Vol.31 Issue 5, pp.502-505

Document Type:

Article

Publication Date:

9/2006

Document Language:

English

Document ID (Org No.):

2000814171

Frequency:

Bimonthly

eISSN:

1017-995X

pISSN:

1017-995X