Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery

Hakika ERDOGAN; Orkun MUHSİNOGLU

doi:https://doi.org/10.19127/bshealthscience.788064

Article Details

Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery

Authors:

Hakika ERDOGAN | Orkun MUHSİNOGLU

Publisher:

Cem TIRINK

Main Topics:

Surgery & related medical specialties

Journal:

Black Sea Journal of Health Science 2021 Vol.4 Issue 1, pp.17-21

Document Type:

Article

Publication Date:

12/2020

Document Language:

English

Document ID (Org No.):

2000895730

Frequency:

Tri-annual

eISSN:

2619-9041

DOI:

https://doi.org/10.19127/bshealthscience.788064

Abstract:

 

This study aimed to evaluate the efficacy of hyaluronic acid/trehalose drop for corneal epithelial and stromal healing after phacoemulsification surgery at Maltepe University, Department of Ophthalmology, Istanbul, Turkey. It is a retrospective randomized comparative study.The patients had phacoemulsification surgery divided into two groups. These patients received either a mixture of sodium hyaluronate and trehalose (HT, Thealoz Duo®, Thea)(Group 1) or sodium hyaluronate 0.15% (Eye Still®; Teka) (Group 2) postoperatively. Effect on corneal epithelial and stromal healing was evaluated using Oxford staining and the vertical scar length measured by optic coherence tomography (OCT) respectively. Preoperative and postoperative findings for Oxford staining, Schirmer’s test, tear film break-uptime (TBUT) and ocular surface disease index(OSDI) scores were also evaluated. The correlation between scar length and tear film parameters was examined. The effect of trehalose on the epithelial healing and stromal scar formation was evaluated. Group 1 and 2 each had 30 eyes. The two groups were similar according to age and sex distribution. In terms of epithelial healing, it was faster in the trehalose group, although there was no statistical difference between the two groups. The length of the stromal scar was not significantly different between groups, though a smaller scar formation was observed in group 1 compared to those in group 2 at both 1 week and 1 month postoperatively. There was also no significant difference between the groups in tear film parameters. The stromal scar length was correlated with the Schirmer test on the 15th day. Although it was not statistically significant, the hyaluronic acid/trehalose may affect epithelial healing and stromal scar formation in a positive way after phacoemulsification surgery. Larger and longer studies are needed.

Article Details

Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery

Authors: Hakika ERDOGAN | Orkun MUHSİNOGLU

Publisher: Cem TIRINK

Main Topics: Surgery & related medical specialties

Journal: Black Sea Journal of Health Science 2021 Vol.4 Issue 1, pp.17-21

Document Type: Article

Publication Date: 12/2020

Document Language: English

Document ID (Org No.): 2000895730

Frequency: Tri-annual

eISSN: 2619-9041

DOI: https://doi.org/10.19127/bshealthscience.788064

Issues

Authors:

Hakika ERDOGAN | Orkun MUHSİNOGLU

Publisher:

Cem TIRINK

Main Topics:

Surgery & related medical specialties

Journal:

Black Sea Journal of Health Science 2021 Vol.4 Issue 1, pp.17-21

Document Type:

Article

Publication Date:

12/2020

Document Language:

English

Document ID (Org No.):

2000895730

Frequency:

Tri-annual

eISSN:

2619-9041

DOI:

https://doi.org/10.19127/bshealthscience.788064