Lisinopril dihydrate loaded nano-spanlastic bio-adhesive gel for intranasal delivery: 23 factorial optimization, fabrication and ex-vivo studies for enhanced mucosal permeation

N.A.

Article Details

Lisinopril dihydrate loaded nano-spanlastic bio-adhesive gel for intranasal delivery: 23 factorial optimization, fabrication and ex-vivo studies for enhanced mucosal permeation

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmaceutical Sciences

Journal:

Journal of Research in Pharmacy Vol.26 Issue 4, pp.884-899

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347281

pISSN:

2630-6344

Keywords:

Abstract:

 Lisinopril dihydrate LP is an FDA approved drug used in the treatment of hypertension. When administered orally it is slowly and incompletely absorbed with a bioavailability of 2530 only. The aim of the present study is to increase the bioavailability of LP by formulating into nano-spanlastic bio-adhesive gel for intranasal delivery. LP loaded nano-spanlastics LPSp were prepared by ethanol injection method according to 23 factorial designs using Design Expert software, to explore the impact of different independent variables on Particle Size PS and Entrapment efficiency EE. The optimized LPSp was evaluated for PS, surface morphology, polydispersity index PDI, zeta potential, EE and in-vitro drug release. Further, the optimized LPSp was loaded into Carbopol gel base 1 and evaluated for pH, percentage drug content, texture properties and rheology. The permeation and histopathological studies were carried out using goat nasal mucosa. The optimized LPSp possessed spherical shape with PS and EE of 3204.5 nm and 722.5 respectively. Drug release studies revealed that the drug enclosed in spanlastic dispersion showed higher drug release compared to niosome dispersion. The LPSp gels exhibited satisfactory results for pH, drug content, texture properties and rheology. The ex-vivo results showed that the permeation rate of LP loaded nanospanlastic bio-adhesive gel LPSpG increased when compared to that of LP loaded niosome gel LPNiG. The results infer that encapsulating LP into vesicular carriers and formulating into a bio-adhesive gel augments its permeation and increases the residence time in nasal mucosa and therefore enhances its bioavailability.

 Lisinopril dihydrate LP is an FDA approved drug used in the treatment of hypertension. When administered orally it is slowly and incompletely absorbed with a bioavailability of 2530 only. The aim of the present study is to increase the bioavailability of LP by formulating into nano-spanlastic bio-adhesive gel for intranasal delivery. LP loaded nano-spanlastics LPSp were prepared by ethanol injection method according to 23 factorial designs using Design Expert software, to explore the impact of different independent variables on Particle Size PS and Entrapment efficiency EE. The optimized LPSp was evaluated for PS, surface morphology, polydispersity index PDI, zeta potential, EE and in-vitro drug release. Further, the optimized LPSp was loaded into Carbopol gel base 1 and evaluated for pH, percentage drug content, texture properties and rheology. The permeation and histopathological studies were carried out using goat nasal mucosa. The optimized LPSp possessed spherical shape with PS and EE of 3204.5 nm and 722.5 respectively. Drug release studies revealed that the drug enclosed in spanlastic dispersion showed higher drug release compared to niosome dispersion. The LPSp gels exhibited satisfactory results for pH, drug content, texture properties and rheology. The ex-vivo results showed that the permeation rate of LP loaded nanospanlastic bio-adhesive gel LPSpG increased when compared to that of LP loaded niosome gel LPNiG. The results infer that encapsulating LP into vesicular carriers and formulating into a bio-adhesive gel augments its permeation and increases the residence time in nasal mucosa and therefore enhances its bioavailability.

 Lisinopril dihydrate LP is an FDA approved drug used in the treatment of hypertension. When administered orally it is slowly and incompletely absorbed with a bioavailability of 2530 only. The aim of the present study is to increase the bioavailability of LP by formulating into nano-spanlastic bio-adhesive gel for intranasal delivery. LP loaded nano-spanlastics LPSp were prepared by ethanol injection method according to 23 factorial designs using Design Expert software, to explore the impact of different independent variables on Particle Size PS and Entrapment efficiency EE. The optimized LPSp was evaluated for PS, surface morphology, polydispersity index PDI, zeta potential, EE and in-vitro drug release. Further, the optimized LPSp was loaded into Carbopol gel base 1 and evaluated for pH, percentage drug content, texture properties and rheology. The permeation and histopathological studies were carried out using goat nasal mucosa. The optimized LPSp possessed spherical shape with PS and EE of 3204.5 nm and 722.5 respectively. Drug release studies revealed that the drug enclosed in spanlastic dispersion showed higher drug release compared to niosome dispersion. The LPSp gels exhibited satisfactory results for pH, drug content, texture properties and rheology. The ex-vivo results showed that the permeation rate of LP loaded nanospanlastic bio-adhesive gel LPSpG increased when compared to that of LP loaded niosome gel LPNiG. The results infer that encapsulating LP into vesicular carriers and formulating into a bio-adhesive gel augments its permeation and increases the residence time in nasal mucosa and therefore enhances its bioavailability.

 Lisinopril dihydrate LP is an FDA approved drug used in the treatment of hypertension. When administered orally it is slowly and incompletely absorbed with a bioavailability of 2530 only. The aim of the present study is to increase the bioavailability of LP by formulating into nano-spanlastic bio-adhesive gel for intranasal delivery. LP loaded nano-spanlastics LPSp were prepared by ethanol injection method according to 23 factorial designs using Design Expert software, to explore the impact of different independent variables on Particle Size PS and Entrapment efficiency EE. The optimized LPSp was evaluated for PS, surface morphology, polydispersity index PDI, zeta potential, EE and in-vitro drug release. Further, the optimized LPSp was loaded into Carbopol gel base 1 and evaluated for pH, percentage drug content, texture properties and rheology. The permeation and histopathological studies were carried out using goat nasal mucosa. The optimized LPSp possessed spherical shape with PS and EE of 3204.5 nm and 722.5 respectively. Drug release studies revealed that the drug enclosed in spanlastic dispersion showed higher drug release compared to niosome dispersion. The LPSp gels exhibited satisfactory results for pH, drug content, texture properties and rheology. The ex-vivo results showed that the permeation rate of LP loaded nanospanlastic bio-adhesive gel LPSpG increased when compared to that of LP loaded niosome gel LPNiG. The results infer that encapsulating LP into vesicular carriers and formulating into a bio-adhesive gel augments its permeation and increases the residence time in nasal mucosa and therefore enhances its bioavailability.

Article Details

Lisinopril dihydrate loaded nano-spanlastic bio-adhesive gel for intranasal delivery: 23 factorial optimization, fabrication and ex-vivo studies for enhanced mucosal permeation

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmaceutical Sciences

Journal:

Journal of Research in Pharmacy Vol.26 Issue 4, pp.884-899

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347281

pISSN:

2630-6344

Lisinopril dihydrate

spanlastic

edge activator

permeation

intranasal route

bio-adhesive gel

Issues

Article Details

Lisinopril dihydrate loaded nano-spanlastic bio-adhesive gel for intranasal delivery: 23 factorial optimization, fabrication and ex-vivo studies for enhanced mucosal permeation

Authors: N.A.

Publisher: Marmara University

Main Topics: Pharmaceutical Sciences

Journal: Journal of Research in Pharmacy Vol.26 Issue 4, pp.884-899

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001347281

pISSN: 2630-6344

Lisinopril dihydrate

spanlastic

edge activator

permeation

intranasal route

bio-adhesive gel

Issues

Authors:

N.A.

Publisher:

Marmara University

Main Topics:

Pharmaceutical Sciences

Journal:

Journal of Research in Pharmacy Vol.26 Issue 4, pp.884-899

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347281

pISSN:

2630-6344