Synthesis of Some New 1-Acylthiosemicarbazides and 1,2,4-Triazol-5-Thiones, and Their Analgesic and Anti-Inflammatory Activities

Yasemin DÜNDAR; Bilge ÇAKIR; Esra KÜPELİ

Article Details

Synthesis of Some New 1-Acylthiosemicarbazides and 1,2,4-Triazol-5-Thiones, and Their Analgesic and Anti-Inflammatory Activities

Authors:

Yasemin DÜNDAR | Bilge ÇAKIR | Esra KÜPELİ

Publisher:

TUBITAK

Main Topics:

Applied physics

Journal:

Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.301-313

Document Type:

Article

Publication Date:

2/2007

Document Language:

English

Document ID (Org No.):

2000728713

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

Abstract:

 

We synthesized new 1-[3-(2-oxobenzothiazolin-3-yl)propanoyl]-4-  substituted-thiosemicarbazides and their corresponding cyclized  3-[2-(2-oxobenzothiazoline-3-yl)ethyl]-4-substituted-1,2,4-triazol-5-thione  ana-logs in which position 4 of the triazole ring was substituted by  cyclohexyl, methyl, allyl, phenyl, p-methylphenyl, p-methoxyphenyl,  p-chlorophenyl, p-nitrophenyl, benzyl, and phenylethyl to screen their  analgesic and anti-inflammatory activities as well as gastric  ulceration potential in test animals.  None of the compounds, except  5a, 5e, and 5h, caused gastric lesions or bleeding.  Compound 5g  was found to have higher analgesic and anti-inflammatory activity  among the synthesized compounds.

 

We synthesized new 1-[3-(2-oxobenzothiazolin-3-yl)propanoyl]-4-  substituted-thiosemicarbazides and their corresponding cyclized  3-[2-(2-oxobenzothiazoline-3-yl)ethyl]-4-substituted-1,2,4-triazol-5-thione  ana-logs in which position 4 of the triazole ring was substituted by  cyclohexyl, methyl, allyl, phenyl, p-methylphenyl, p-methoxyphenyl,  p-chlorophenyl, p-nitrophenyl, benzyl, and phenylethyl to screen their  analgesic and anti-inflammatory activities as well as gastric  ulceration potential in test animals.  None of the compounds, except  5a, 5e, and 5h, caused gastric lesions or bleeding.  Compound 5g  was found to have higher analgesic and anti-inflammatory activity  among the synthesized compounds.

Article Details

Synthesis of Some New 1-Acylthiosemicarbazides and 1,2,4-Triazol-5-Thiones, and Their Analgesic and Anti-Inflammatory Activities

Authors: Yasemin DÜNDAR | Bilge ÇAKIR | Esra KÜPELİ

Publisher: TUBITAK

Main Topics: Applied physics

Journal: Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.301-313

Document Type: Article

Publication Date: 2/2007

Document Language: English

Document ID (Org No.): 2000728713

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

Issues

Authors:

Yasemin DÜNDAR | Bilge ÇAKIR | Esra KÜPELİ

Publisher:

TUBITAK

Main Topics:

Applied physics

Journal:

Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.301-313

Document Type:

Article

Publication Date:

2/2007

Document Language:

English

Document ID (Org No.):

2000728713

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527