CAN GINGIVAL CREVICULAR FLUID HELP IN DIAGNOSING PULP INFLAMMATION? A SYSTEMATIC REVIEW

Wael Kassamany; Roula Abiad

Article Details

CAN GINGIVAL CREVICULAR FLUID HELP IN DIAGNOSING PULP INFLAMMATION? A SYSTEMATIC REVIEW

Authors:

Wael Kassamany | Roula Abiad

Publisher:

Beirut Arab University Press

Journal:

BAU Journal - Science and Technology Vol.7 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

6/2026

Document Language:

English

Document ID (Org No.):

2001951602

pISSN:

2959-331X

Keywords:

Abstract:

 This review aims to find if there’s a positive correlation between biological markers detected in human gingival crevicular fluid and pulp inflammation.
An electronic search of three databases; PubMed, EBSCOhost and Google Scholar was conducted using the keywords “tooth or teeth or pulp” AND “gingival crevice fluid or gingival crevicular fluid” for English articles published between the year 1990 and 2026. Information regarding study design, patients age range and gender distribution, sampling method used, types of biomarkers studied, assay test used, and key findings of each article were extracted and analyzed.
Biomarkers studied were substance P “SP”, neurokinin A “NKA”, interleukin-8 “IL-8”, tumor necrosis factor alpha “TNF-α”, calcitonin gene-related peptide “CGRP” and human nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing-3 protein “NLRP3”. The sampling method most commonly used to collect the gingival crevicular fluid (GCF) was a periopaper strip placed within the gingival sulcus for 1 minute. As for the assay test, ELISA (enzyme-linked immunosorbent assay) was found to be the most frequently used. In all studies included in this review, higher levels of biomarkers were detected when pulp inflammation/stimulation was present. These levels decreased significantly 1 week after pulpectomy in interventional studies.
Pulp inflammation can be associated with elevated levels of biomarkers in GCF, however future studies are needed to investigate the possibility of correlating certain biomarkers and their levels specifically and accurately with pulpal conditions.

Article Details

CAN GINGIVAL CREVICULAR FLUID HELP IN DIAGNOSING PULP INFLAMMATION? A SYSTEMATIC REVIEW

Authors:

Wael Kassamany | Roula Abiad

Publisher:

Beirut Arab University Press

Journal:

BAU Journal - Science and Technology Vol.7 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

6/2026

Document Language:

English

Document ID (Org No.):

2001951602

pISSN:

2959-331X

Biomarkers

Inflammatory markers

Cytokines

Pulp inflammation

Gingival crevicular fluid.

Issues

Article Details

CAN GINGIVAL CREVICULAR FLUID HELP IN DIAGNOSING PULP INFLAMMATION? A SYSTEMATIC REVIEW

Authors: Wael Kassamany | Roula Abiad

Publisher: Beirut Arab University Press

Journal: BAU Journal - Science and Technology Vol.7 Issue 2, pp.0-0

Document Type: Article

Publication Date: 6/2026

Document Language: English

Document ID (Org No.): 2001951602

pISSN: 2959-331X

Biomarkers

Inflammatory markers

Cytokines

Pulp inflammation

Gingival crevicular fluid.

Issues

Authors:

Wael Kassamany | Roula Abiad

Publisher:

Beirut Arab University Press

Journal:

BAU Journal - Science and Technology Vol.7 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

6/2026

Document Language:

English

Document ID (Org No.):

2001951602

pISSN:

2959-331X