Diagnostic and Prognostic Value of Serum Vitronectin and Galectin-3 levels in Thyroid Tumors

Esra Arslan; Göksel Alçın; Bağnu Orhan; Derya Sönmez; F.didem Can Trabulus; Ahmet Volkan Sünter; Kıvılcım Ulusan

Article Details

Diagnostic and Prognostic Value of Serum Vitronectin and Galectin-3 levels in Thyroid Tumors

Authors:

Esra Arslan | Göksel Alçın | Bağnu Orhan | Derya Sönmez | F.didem Can Trabulus | Ahmet Volkan Sünter | Kıvılcım Ulusan

Publisher:

Mersin University

Main Topics:

Endocrinology | Nuclear Medicine

Journal:

Molecular Oncologic Imaging Vol.4 Issue 3, pp.18-26

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001339020

pISSN:

2791-965X

Keywords:

Abstract:

 Objective: Increased expression of Galectin-3Gal-3 and Vitronectin VN molecules has been the subject of research, since it may be a biological marker that can be used for the separation of benign and malignant tissues. We aimed to evaluate serum Gal-3 and VN expression levels in the presence of thyroid tissue, and evaluate the predictive and prognostic value of these molecules in the differential diagnosis of malignant tissues. Materials and Methods: 44 patients with thyroid nodules were included in this prospective study. Benign and malignant lesions were distinguished from thyroidectomy materials. Results: Mean preoperative Gal-3 and VN values measured in malignant lesions were statistically significantly higher than preoperative Gal-3 and VN values in benign lesions p-values: 0.007 and 0.009, respectively. Also, mean Gal-3 and VN values measured in serum were significantly reduced after operation compared to preoperative values p-values0.001 and 0.001, respectively. Mean preoperative Gal-3 and VN values were found statistically significantly higher if there is capsular invasion p-values: 0.033 and 0.026, respectively. Conclusion: The serum Gal-3 and VN concentrations are increased in thyroid cancer and in the presence of capsular invasion. And also decreased during the postoperative period significantly. Our findings will contribute to the literature in order to improve correct diagnosis and mortality rates in thyroid lesions.

 Objective: Increased expression of Galectin-3Gal-3 and Vitronectin VN molecules has been the subject of research, since it may be a biological marker that can be used for the separation of benign and malignant tissues. We aimed to evaluate serum Gal-3 and VN expression levels in the presence of thyroid tissue, and evaluate the predictive and prognostic value of these molecules in the differential diagnosis of malignant tissues. Materials and Methods: 44 patients with thyroid nodules were included in this prospective study. Benign and malignant lesions were distinguished from thyroidectomy materials. Results: Mean preoperative Gal-3 and VN values measured in malignant lesions were statistically significantly higher than preoperative Gal-3 and VN values in benign lesions p-values: 0.007 and 0.009, respectively. Also, mean Gal-3 and VN values measured in serum were significantly reduced after operation compared to preoperative values p-values0.001 and 0.001, respectively. Mean preoperative Gal-3 and VN values were found statistically significantly higher if there is capsular invasion p-values: 0.033 and 0.026, respectively. Conclusion: The serum Gal-3 and VN concentrations are increased in thyroid cancer and in the presence of capsular invasion. And also decreased during the postoperative period significantly. Our findings will contribute to the literature in order to improve correct diagnosis and mortality rates in thyroid lesions.

 Objective: Increased expression of Galectin-3Gal-3 and Vitronectin VN molecules has been the subject of research, since it may be a biological marker that can be used for the separation of benign and malignant tissues. We aimed to evaluate serum Gal-3 and VN expression levels in the presence of thyroid tissue, and evaluate the predictive and prognostic value of these molecules in the differential diagnosis of malignant tissues. Materials and Methods: 44 patients with thyroid nodules were included in this prospective study. Benign and malignant lesions were distinguished from thyroidectomy materials. Results: Mean preoperative Gal-3 and VN values measured in malignant lesions were statistically significantly higher than preoperative Gal-3 and VN values in benign lesions p-values: 0.007 and 0.009, respectively. Also, mean Gal-3 and VN values measured in serum were significantly reduced after operation compared to preoperative values p-values0.001 and 0.001, respectively. Mean preoperative Gal-3 and VN values were found statistically significantly higher if there is capsular invasion p-values: 0.033 and 0.026, respectively. Conclusion: The serum Gal-3 and VN concentrations are increased in thyroid cancer and in the presence of capsular invasion. And also decreased during the postoperative period significantly. Our findings will contribute to the literature in order to improve correct diagnosis and mortality rates in thyroid lesions.

 Objective: Increased expression of Galectin-3Gal-3 and Vitronectin VN molecules has been the subject of research, since it may be a biological marker that can be used for the separation of benign and malignant tissues. We aimed to evaluate serum Gal-3 and VN expression levels in the presence of thyroid tissue, and evaluate the predictive and prognostic value of these molecules in the differential diagnosis of malignant tissues. Materials and Methods: 44 patients with thyroid nodules were included in this prospective study. Benign and malignant lesions were distinguished from thyroidectomy materials. Results: Mean preoperative Gal-3 and VN values measured in malignant lesions were statistically significantly higher than preoperative Gal-3 and VN values in benign lesions p-values: 0.007 and 0.009, respectively. Also, mean Gal-3 and VN values measured in serum were significantly reduced after operation compared to preoperative values p-values0.001 and 0.001, respectively. Mean preoperative Gal-3 and VN values were found statistically significantly higher if there is capsular invasion p-values: 0.033 and 0.026, respectively. Conclusion: The serum Gal-3 and VN concentrations are increased in thyroid cancer and in the presence of capsular invasion. And also decreased during the postoperative period significantly. Our findings will contribute to the literature in order to improve correct diagnosis and mortality rates in thyroid lesions.

Article Details

Diagnostic and Prognostic Value of Serum Vitronectin and Galectin-3 levels in Thyroid Tumors

Authors:

Esra Arslan | Göksel Alçın | Bağnu Orhan | Derya Sönmez | F.didem Can Trabulus | Ahmet Volkan Sünter | Kıvılcım Ulusan

Publisher:

Mersin University

Main Topics:

Endocrinology | Nuclear Medicine

Journal:

Molecular Oncologic Imaging Vol.4 Issue 3, pp.18-26

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001339020

pISSN:

2791-965X

Thyroid cancer

thyroid nodules

Vitronectin

Galectin-3

Prognosis

Diagnosis

Issues

Article Details

Diagnostic and Prognostic Value of Serum Vitronectin and Galectin-3 levels in Thyroid Tumors

Authors: Esra Arslan | Göksel Alçın | Bağnu Orhan | Derya Sönmez | F.didem Can Trabulus | Ahmet Volkan Sünter | Kıvılcım Ulusan

Publisher: Mersin University

Main Topics: Endocrinology | Nuclear Medicine

Journal: Molecular Oncologic Imaging Vol.4 Issue 3, pp.18-26

Document Type: Article

Publication Date: 1/2025

Document Language: English

Document ID (Org No.): 2001339020

pISSN: 2791-965X

Thyroid cancer

thyroid nodules

Vitronectin

Galectin-3

Prognosis

Diagnosis

Issues

Authors:

Esra Arslan | Göksel Alçın | Bağnu Orhan | Derya Sönmez | F.didem Can Trabulus | Ahmet Volkan Sünter | Kıvılcım Ulusan

Publisher:

Mersin University

Main Topics:

Endocrinology | Nuclear Medicine

Journal:

Molecular Oncologic Imaging Vol.4 Issue 3, pp.18-26

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001339020

pISSN:

2791-965X