Assessment of macular microcirculation in patients with multiple sclerosis by swept-source optical coherence tomography angiography

Serhat Eker; Yalçın Karaküçük; Haluk Gumus

Article Details

Assessment of macular microcirculation in patients with multiple sclerosis by swept-source optical coherence tomography angiography

Authors:

Serhat Eker | Yalçın Karaküçük | Haluk Gumus

Publisher:

Marmara University

Main Topics:

Surgery (Other)

Journal:

Marmara Medical Journal Vol.37 Issue 2, pp.192-197

Document Type:

Article

Publication Date:

5/2024

Document Language:

English

Document ID (Org No.):

2001317375

pISSN:

1019-1941

Keywords:

Abstract:

 Objective: To investigate the changes in the retinal microcirculation in multiple sclerosis MS patients by swept-source optical coherence tomography angiography SS-OCTA. Patients and Methods: Thirty-seven patients with relapsing-remitting MS and 40 healthy volunteers were included into this crosssectional study. Clinical history, Expanded Disability Status Scale and duration of MS were collected. SS-OCTA by deep range imaging DRI OCT measurements were performed on all subjects. Macular perfusion parameters including superficial and deep foveal avascular zones FAZs, FAZd, respectively , vascular densities of superficial capillary plexus SCP , deep capillary plexus DCP  and choriocapillaris CC  were compared with healthy subjects. Results: Vascular densities of SCP, DCP and CC were found to be statistically lower in the study group compared to the control group p  0.02, p  0.03, p  0.03, respectively. FAZs and FAZd, areas were significantly higher in the study group p  0.02, p  0.02, respectively. Central macular thickness and subfoveal choroidal thickness were significantly lower than in the control group p  0.015, p  0.047, respectively. Conclusion: Evaluation of retinal blood flow in patients with MS is useful both for understanding the physiopathology of the disease and in the clinical follow-up.

 Objective: To investigate the changes in the retinal microcirculation in multiple sclerosis MS patients by swept-source optical coherence tomography angiography SS-OCTA. Patients and Methods: Thirty-seven patients with relapsing-remitting MS and 40 healthy volunteers were included into this crosssectional study. Clinical history, Expanded Disability Status Scale and duration of MS were collected. SS-OCTA by deep range imaging DRI OCT measurements were performed on all subjects. Macular perfusion parameters including superficial and deep foveal avascular zones FAZs, FAZd, respectively , vascular densities of superficial capillary plexus SCP , deep capillary plexus DCP  and choriocapillaris CC  were compared with healthy subjects. Results: Vascular densities of SCP, DCP and CC were found to be statistically lower in the study group compared to the control group p  0.02, p  0.03, p  0.03, respectively. FAZs and FAZd, areas were significantly higher in the study group p  0.02, p  0.02, respectively. Central macular thickness and subfoveal choroidal thickness were significantly lower than in the control group p  0.015, p  0.047, respectively. Conclusion: Evaluation of retinal blood flow in patients with MS is useful both for understanding the physiopathology of the disease and in the clinical follow-up.

 Objective: To investigate the changes in the retinal microcirculation in multiple sclerosis MS patients by swept-source optical coherence tomography angiography SS-OCTA. Patients and Methods: Thirty-seven patients with relapsing-remitting MS and 40 healthy volunteers were included into this crosssectional study. Clinical history, Expanded Disability Status Scale and duration of MS were collected. SS-OCTA by deep range imaging DRI OCT measurements were performed on all subjects. Macular perfusion parameters including superficial and deep foveal avascular zones FAZs, FAZd, respectively , vascular densities of superficial capillary plexus SCP , deep capillary plexus DCP  and choriocapillaris CC  were compared with healthy subjects. Results: Vascular densities of SCP, DCP and CC were found to be statistically lower in the study group compared to the control group p  0.02, p  0.03, p  0.03, respectively. FAZs and FAZd, areas were significantly higher in the study group p  0.02, p  0.02, respectively. Central macular thickness and subfoveal choroidal thickness were significantly lower than in the control group p  0.015, p  0.047, respectively. Conclusion: Evaluation of retinal blood flow in patients with MS is useful both for understanding the physiopathology of the disease and in the clinical follow-up.

 Objective: To investigate the changes in the retinal microcirculation in multiple sclerosis MS patients by swept-source optical coherence tomography angiography SS-OCTA. Patients and Methods: Thirty-seven patients with relapsing-remitting MS and 40 healthy volunteers were included into this crosssectional study. Clinical history, Expanded Disability Status Scale and duration of MS were collected. SS-OCTA by deep range imaging DRI OCT measurements were performed on all subjects. Macular perfusion parameters including superficial and deep foveal avascular zones FAZs, FAZd, respectively , vascular densities of superficial capillary plexus SCP , deep capillary plexus DCP  and choriocapillaris CC  were compared with healthy subjects. Results: Vascular densities of SCP, DCP and CC were found to be statistically lower in the study group compared to the control group p  0.02, p  0.03, p  0.03, respectively. FAZs and FAZd, areas were significantly higher in the study group p  0.02, p  0.02, respectively. Central macular thickness and subfoveal choroidal thickness were significantly lower than in the control group p  0.015, p  0.047, respectively. Conclusion: Evaluation of retinal blood flow in patients with MS is useful both for understanding the physiopathology of the disease and in the clinical follow-up.

Article Details

Assessment of macular microcirculation in patients with multiple sclerosis by swept-source optical coherence tomography angiography

Authors:

Serhat Eker | Yalçın Karaküçük | Haluk Gumus

Publisher:

Marmara University

Main Topics:

Surgery (Other)

Journal:

Marmara Medical Journal Vol.37 Issue 2, pp.192-197

Document Type:

Article

Publication Date:

5/2024

Document Language:

English

Document ID (Org No.):

2001317375

pISSN:

1019-1941

Multiple sclerosis

Retinal vasculature

Vascular density

Macular perfusion

Swept-source optical coherence tomography angiography

Issues

Article Details

Assessment of macular microcirculation in patients with multiple sclerosis by swept-source optical coherence tomography angiography

Authors: Serhat Eker | Yalçın Karaküçük | Haluk Gumus

Publisher: Marmara University

Main Topics: Surgery (Other)

Journal: Marmara Medical Journal Vol.37 Issue 2, pp.192-197

Document Type: Article

Publication Date: 5/2024

Document Language: English

Document ID (Org No.): 2001317375

pISSN: 1019-1941

Multiple sclerosis

Retinal vasculature

Vascular density

Macular perfusion

Swept-source optical coherence tomography angiography

Issues

Authors:

Serhat Eker | Yalçın Karaküçük | Haluk Gumus

Publisher:

Marmara University

Main Topics:

Surgery (Other)

Journal:

Marmara Medical Journal Vol.37 Issue 2, pp.192-197

Document Type:

Article

Publication Date:

5/2024

Document Language:

English

Document ID (Org No.):

2001317375

pISSN:

1019-1941