Addition of hyperthermic intraperitoneal chemotherapy (HIPEC) after complete cytoreductive surgery in a child with desmoplastic small round cell tumour

İbrahim KARTAL; Koray TOPGÜL; Mustafa Kemal ASLAN; Ayhan DAĞDEMİR; Emel ÖZYÜREK; Şaban SARIKAYA

Article Details

Addition of hyperthermic intraperitoneal chemotherapy (HIPEC) after complete cytoreductive surgery in a child with desmoplastic small round cell tumour

Authors:

İbrahim KARTAL | Koray TOPGÜL | Mustafa Kemal ASLAN | Ayhan DAĞDEMİR | Emel ÖZYÜREK | Şaban SARIKAYA

Publisher:

Ondokuz Mayıs University

Main Topics:

Promotion of health

Journal:

Journal of Experimental and Clinical Medicine 2019 Vol.36 Issue 4, pp.131-135

Document Type:

Article

Publication Date:

3/2020

Document Language:

English

Document ID (Org No.):

2000507822

Frequency:

Quarterly

eISSN:

1309-5129

pISSN:

1309-4483

Abstract:

 


Desmoplastic small round cell tumour (DSRCT) is a rare and aggressive sarcoma. No curative treatment has been reported yet; however, multi-agent chemotherapy, an aggressive surgical approach and radiotherapy have been used. Hyperthermic intraperitoneal chemotherapy (HIPEC) is an additional strategy used to remove microscopic disease after cytoreduction, especially in patients with peritoneal carcinomatosis and colorectal cancer; however, its application in paediatric patients has been reported rarely. In Turkey, some HIPEC studies have been performed in adult patients but not in paediatric patients. A 10-yearold girl presented to the hospital with a mass palpated in the left lumbar region. The mass was reported as a primitive neuroectodermal tumour after the biopsy. Left radical nephrectomy and lymph node dissection were performed after she failed to respond to five months of neoadjuvant chemotherapy. The pathological examination revealed a DSRCT. A multi-agent chemotherapy regimen was applied to the patient for one year. Myeloablative chemotherapy and autologous stem cell transplantation were performed in the patient, who subsequently entered remission. During the third month of follow-up, high-dose multi-agent chemotherapy protocols were initiated because of disease relapse. At 6 months after recurrence, HIPEC with irinotecan and oxaliplatin was performed after the excision of all tumour foci by intracavitary cytoreductive surgery. No complications were observed. The patient was prescribed a tyrosine kinase receptor inhibitor (sunitinib maleate). The patient died 8 months later. In conclusion, although the benefit of HIPEC is still unknown and requires evaluation in a prospective trial, HIPEC can be used as an alternative treatment in paediatric patients with peritoneal carcinomatosis. 


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Article Details

Addition of hyperthermic intraperitoneal chemotherapy (HIPEC) after complete cytoreductive surgery in a child with desmoplastic small round cell tumour

Authors: İbrahim KARTAL | Koray TOPGÜL | Mustafa Kemal ASLAN | Ayhan DAĞDEMİR | Emel ÖZYÜREK | Şaban SARIKAYA

Publisher: Ondokuz Mayıs University

Main Topics: Promotion of health

Journal: Journal of Experimental and Clinical Medicine 2019 Vol.36 Issue 4, pp.131-135

Document Type: Article

Publication Date: 3/2020

Document Language: English

Document ID (Org No.): 2000507822

Frequency: Quarterly

eISSN: 1309-5129

pISSN: 1309-4483

Issues

Authors:

İbrahim KARTAL | Koray TOPGÜL | Mustafa Kemal ASLAN | Ayhan DAĞDEMİR | Emel ÖZYÜREK | Şaban SARIKAYA

Publisher:

Ondokuz Mayıs University

Main Topics:

Promotion of health

Journal:

Journal of Experimental and Clinical Medicine 2019 Vol.36 Issue 4, pp.131-135

Document Type:

Article

Publication Date:

3/2020

Document Language:

English

Document ID (Org No.):

2000507822

Frequency:

Quarterly

eISSN:

1309-5129

pISSN:

1309-4483