The effects of exposure to microplastics in drinking water on sperm parameters and TNP1 and TNP2 sperm nuclear protein genes

Harika Topal Önal; Tiinçe Aksak; İzzet Oğuz

Article Details

The effects of exposure to microplastics in drinking water on sperm parameters and TNP1 and TNP2 sperm nuclear protein genes

Authors:

Harika Topal Önal | Tiinçe Aksak | İzzet Oğuz

Publisher:

Cukurova University

Main Topics:

Tıbbi Genetik (Kanser Genetiği hariç) | Üroloji | Histoloji ve Embriyoloji

Journal:

Cukurova Medical Journal Vol.49 Issue 2, pp.320-331

Document Type:

Article

Publication Date:

6/2024

Document Language:

English

Document ID (Org No.):

2001320787

pISSN:

2602-3032

Keywords:

Abstract:

 Purpose: Microplastics have emerged as a significant concern amid the rise in environmental pollution. Nevertheless, the potential impacts of microplastics present in drinking water on human health remain inadequately understood. This study aims to explore the exposure to microplastics in drinking water among men who consume water from plastic bottles and carboys compared to those who consume tap water. Materials and Methods: A total of 100 patients were included in the study, 50 of whom used only tap water and 50 of whom used plastic bottles and carboys. In addition, this study evaluated the effects of exposure on sperm parameters and potential effects on the expression levels of the sperm nuclear protein genes transition protein 1 gene TNP1 and TNP2. Results: According to the findings, it was observed that the incidence of amorphous headache anomalies among individuals using plastic bottled water was significantly higher compared to those using tap water. In addition, the coiled tail anomaly and the terminal droplet anomaly in the tail were also observed to be significantly higher in people using plastic bottles compared to those using tap water. The results show that exposure to microplastics in drinking water can affect male sperm parameters and alter the expression of TNP1 and TNP2 genes. Conclusion: It was found that there were differences in exposure levels between those who consumed plastic bottles and carboy water, and those who consumed municipal water.

 Purpose: Microplastics have emerged as a significant concern amid the rise in environmental pollution. Nevertheless, the potential impacts of microplastics present in drinking water on human health remain inadequately understood. This study aims to explore the exposure to microplastics in drinking water among men who consume water from plastic bottles and carboys compared to those who consume tap water. Materials and Methods: A total of 100 patients were included in the study, 50 of whom used only tap water and 50 of whom used plastic bottles and carboys. In addition, this study evaluated the effects of exposure on sperm parameters and potential effects on the expression levels of the sperm nuclear protein genes transition protein 1 gene TNP1 and TNP2. Results: According to the findings, it was observed that the incidence of amorphous headache anomalies among individuals using plastic bottled water was significantly higher compared to those using tap water. In addition, the coiled tail anomaly and the terminal droplet anomaly in the tail were also observed to be significantly higher in people using plastic bottles compared to those using tap water. The results show that exposure to microplastics in drinking water can affect male sperm parameters and alter the expression of TNP1 and TNP2 genes. Conclusion: It was found that there were differences in exposure levels between those who consumed plastic bottles and carboy water, and those who consumed municipal water.

 Purpose: Microplastics have emerged as a significant concern amid the rise in environmental pollution. Nevertheless, the potential impacts of microplastics present in drinking water on human health remain inadequately understood. This study aims to explore the exposure to microplastics in drinking water among men who consume water from plastic bottles and carboys compared to those who consume tap water. Materials and Methods: A total of 100 patients were included in the study, 50 of whom used only tap water and 50 of whom used plastic bottles and carboys. In addition, this study evaluated the effects of exposure on sperm parameters and potential effects on the expression levels of the sperm nuclear protein genes transition protein 1 gene TNP1 and TNP2. Results: According to the findings, it was observed that the incidence of amorphous headache anomalies among individuals using plastic bottled water was significantly higher compared to those using tap water. In addition, the coiled tail anomaly and the terminal droplet anomaly in the tail were also observed to be significantly higher in people using plastic bottles compared to those using tap water. The results show that exposure to microplastics in drinking water can affect male sperm parameters and alter the expression of TNP1 and TNP2 genes. Conclusion: It was found that there were differences in exposure levels between those who consumed plastic bottles and carboy water, and those who consumed municipal water.

 Amaç: Mikroplastikler, çevresel kirlilik arttıkça önemli bir endişe kaynağı haline gelmiştir. Ancak, mikroplastiklerin içme suyundaki potansiyel etkileri hala yeterince anlaşılamamıştır. Bu çalışma, plastik şişe ve damacana su tüketen erkekler ile şebeke suyu tüketen erkekler arasındaki içme suyundaki mikroplastiklere maruziyeti araştırmayı amaçlamaktadır. Gereç ve Yöntem: Çalışmaya toplamda 100 hasta dahil edildi, bunlardan 50si sadece şebeke suyu kullanırken 50si plastik şişe ve damacana suyu kullanmaktaydı. Ayrıca, bu çalışma maruziyetin sperm parametreleri üzerindeki etkisini ve sperm nüklear protein genlerinden Transition Protein 1 geni TNP1 ve TNP2nin ekspresyon düzeyleri üzerindeki potansiyel etkileri değerlendirdi. Bulgular: Elde edilen sonuçlara göre, plastik şişe suyu kullananlarda amorf baş anomalisinin, şebeke suyu kullananlara göre belirgin şekilde daha yüksek olduğu saptandı. Ayrıca, plastik şişe kullananlarda bükülmüş kuyruk anomalisi ve kuyruktaki terminal damla anomalisinin de şebeke suyu kullananlara göre anlamlı olarak daha yüksek bulundu. Sonuçlar, içme suyundaki mikroplastiklere maruziyetin erkek sperm parametrelerini etkileyebileceğini ve TNP1 ile TNP2 genlerinin ekspresyonunu değiştirebileceğini göstermektedir. Sonuç: Çalışma plastik şişe ve damacana su tüketenler ile şebeke suyu tüketenler arasında maruziyet düzeylerinde farklılıklar olduğunu ortaya koymuştur.

Article Details

The effects of exposure to microplastics in drinking water on sperm parameters and TNP1 and TNP2 sperm nuclear protein genes

Authors:

Harika Topal Önal | Tiinçe Aksak | İzzet Oğuz

Publisher:

Cukurova University

Main Topics:

Tıbbi Genetik (Kanser Genetiği hariç) | Üroloji | Histoloji ve Embriyoloji

Journal:

Cukurova Medical Journal Vol.49 Issue 2, pp.320-331

Document Type:

Article

Publication Date:

6/2024

Document Language:

English

Document ID (Org No.):

2001320787

pISSN:

2602-3032

Microplastic;

Plastic bottle

Sperm parametres

TNP1

TNP2

Gene expressionMikroplastik

plastik şişe

sperm parametreleri

TNP1

TNP2

gen ekspresyonu

Issues

Article Details

Authors: Harika Topal Önal | Tiinçe Aksak | İzzet Oğuz

Publisher: Cukurova University

Main Topics: Tıbbi Genetik (Kanser Genetiği hariç) | Üroloji | Histoloji ve Embriyoloji

Journal: Cukurova Medical Journal Vol.49 Issue 2, pp.320-331

Document Type: Article

Publication Date: 6/2024

Document Language: English

Document ID (Org No.): 2001320787

pISSN: 2602-3032

Issues

Authors:

Harika Topal Önal | Tiinçe Aksak | İzzet Oğuz

Publisher:

Cukurova University

Main Topics:

Tıbbi Genetik (Kanser Genetiği hariç) | Üroloji | Histoloji ve Embriyoloji

Journal:

Cukurova Medical Journal Vol.49 Issue 2, pp.320-331

Document Type:

Article

Publication Date:

6/2024

Document Language:

English

Document ID (Org No.):

2001320787

pISSN:

2602-3032