Formulation, Characterization and Efficiency Evaluation of a Hydrogel Formulated with Algerian Thermal Water

Romaissaa Mokdad; Abdelkader Hadjsadok; Ali Aouabed

Article Details

Formulation, Characterization and Efficiency Evaluation of a Hydrogel Formulated with Algerian Thermal Water

Authors:

Romaissaa Mokdad | Abdelkader Hadjsadok | Ali Aouabed

Publisher:

Université de Constantine 3

Journal:

Algerian Journal of Engineering Research Vol.2 Issue 3, pp.9-12

Document Type:

Article

Publication Date:

6/2018

Document Language:

English

Document ID (Org No.):

2001540993

pISSN:

2710-8651

Keywords:

Abstract:

 Guergour thermal water (GTW) is commonly used in the east of Algeria for treating atopic dermatitis (AD)
and psoriasis. Previous works demonstrated its chemical composition rich in minerals and heavy metals. The
aims of the present study were (a) to possibly formulate a Hydrogel with GTW as an active agent (b) study the
rheological properties and the stability of this Hydrogel (c) study the clinical efficiency of this Hydrogel
towards atopic dermatitis symptoms.
First, several excipients with both inert physiochemical properties and ability to endure the high salinity of
the thermal water were chosen. Second, a Hydrogel was formulated with the thermal water as the major
component, carrying out rheological properties and stability studies. The Hydrogel was then tested on patients
having AD problems during two weeks. For that, a comparative study was conducted with a Hydrogel with the
same formula, but prepared with purified water as vehicle. The evolution of AD symptoms and signs were
evaluated based on questionnaires for different considered patients.
The GTW being a thermal mineral water emerged with a neutral pH and a highly saline calcium sulfate. The
Hydrogel formulated with GTW presented satisfactory rheological and sensory characteristics and was stable
for 8 months under specific storage conditions. The clinical results revealed that 65% of AD patients showed
significant improvements after the treatment, with partial sore disappearances.
This study provided the possibility to use the GTW as an active agent in a stable Hydrogel with therapeutic
dermal effect. GTW-Hydrogel applied directly to the skin can be a key issue for AD patient caregivers.

Article Details

Formulation, Characterization and Efficiency Evaluation of a Hydrogel Formulated with Algerian Thermal Water

Authors:

Romaissaa Mokdad | Abdelkader Hadjsadok | Ali Aouabed

Publisher:

Université de Constantine 3

Journal:

Algerian Journal of Engineering Research Vol.2 Issue 3, pp.9-12

Document Type:

Article

Publication Date:

6/2018

Document Language:

English

Document ID (Org No.):

2001540993

pISSN:

2710-8651

Atopic Dermatitis

Guergour Thermal Water

Hydrogel

Rheology

Viscosity

Issues

Article Details

Formulation, Characterization and Efficiency Evaluation of a Hydrogel Formulated with Algerian Thermal Water

Authors: Romaissaa Mokdad | Abdelkader Hadjsadok | Ali Aouabed

Publisher: Université de Constantine 3

Journal: Algerian Journal of Engineering Research Vol.2 Issue 3, pp.9-12

Document Type: Article

Publication Date: 6/2018

Document Language: English

Document ID (Org No.): 2001540993

pISSN: 2710-8651

Atopic Dermatitis

Guergour Thermal Water

Hydrogel

Rheology

Viscosity

Issues

Authors:

Romaissaa Mokdad | Abdelkader Hadjsadok | Ali Aouabed

Publisher:

Université de Constantine 3

Journal:

Algerian Journal of Engineering Research Vol.2 Issue 3, pp.9-12

Document Type:

Article

Publication Date:

6/2018

Document Language:

English

Document ID (Org No.):

2001540993

pISSN:

2710-8651