Deregulation of Cancer-Associated Genes in Odontogenic Cysts

Bilal EGE; Önder YUMRUTAŞ; İbrahim BOZGEYİK

doi:https://doi.org/10.7126/cumudj.543875

Article Details

Deregulation of Cancer-Associated Genes in Odontogenic Cysts

Authors:

Bilal EGE | Önder YUMRUTAŞ | İbrahim BOZGEYİK

Main Topics:

Promotion of health

Journal:

Cumhuriyet Dental Journal 2019 Vol.22 Issue 3, pp.268-275

Document Type:

Article

Publication Date:

9/2019

Document Language:

English

Document ID (Org No.):

2000734491

DOI:

https://doi.org/10.7126/cumudj.543875

Abstract:

 


Objectives: The
aim of the present study was to demonstrate the key role of differential
expression levels of RB1, TP53, XIAP, BCL2 AIFM3, BAX, CASP3 and CASP9 genes in
odontogenic cysts. 


Materials and Methods:
A total number of 15 patients who diagnosed with odontogenic cyst were enrolled
for the present study. For the quantitative gene expression analysis, cyst and
adjacent gingival healthy tissues of patients were collected during surgical assessments.
Quantitative analysis of gene expression levels RB1, TP53, XIAP, BCL2 AIFM3,
BAX, CASP3 and CASP9 were achieved real-time PCR method. For the optimization
of gene expression levels GAPDH reference gene was used. 


Results:
Expression of both RB1 and TP53 genes were markedly diminished in odontogenic
cysts tissues as compared to healthy tissues (p0.05). 










Conclusions:
The findings of the present study indicates that RB1, TP53, XIAP, CASP3 and
CASP9 genes might have chief roles in formation odontogenic cysts and
responsible for the increased cell proliferation in these tissues.



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Article Details

Deregulation of Cancer-Associated Genes in Odontogenic Cysts

Authors: Bilal EGE | Önder YUMRUTAŞ | İbrahim BOZGEYİK

Main Topics: Promotion of health

Journal: Cumhuriyet Dental Journal 2019 Vol.22 Issue 3, pp.268-275

Document Type: Article

Publication Date: 9/2019

Document Language: English

Document ID (Org No.): 2000734491

DOI: https://doi.org/10.7126/cumudj.543875

Issues

Authors:

Bilal EGE | Önder YUMRUTAŞ | İbrahim BOZGEYİK

Main Topics:

Promotion of health

Journal:

Cumhuriyet Dental Journal 2019 Vol.22 Issue 3, pp.268-275

Document Type:

Article

Publication Date:

9/2019

Document Language:

English

Document ID (Org No.):

2000734491

DOI:

https://doi.org/10.7126/cumudj.543875