Effect of Formulation Parameters on The Encapsulation of a Hydrophobic Active Ingredient Obtained by Ionic Gelation

Lamoudi Lynda; Akreche Soraya; Daoud Kamel

Article Details

Effect of Formulation Parameters on The Encapsulation of a Hydrophobic Active Ingredient Obtained by Ionic Gelation

Authors:

Lamoudi Lynda | Akreche Soraya | Daoud Kamel

Publisher:

Université des sciences et de la technologie Houari Boumediène alger

Journal:

Algerian Journal of Pharmaceutical Engineering , pp.1-4

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001543933

pISSN:

2992-0639

Keywords:

Abstract:

 Prednisone, a synthetic hormone belonging to the corticosteroid family, is produced by the adrenal glands. In the
medicine, it is known that it is used for its anti-inflammatory properties. In this study it is used as a model
hydrophobic active substance for encapsulation by ion gelation.
For the optimization of the formulation of these microspheres based on sodium alginate, we carried out a
parametric work to study the influence of process and formulation parameters on the encapsulation efficiency of
the active ingredient.
This research consists in determining the influence sodium alginate concentration, Calcium Chloride concentration
and both the quantity and the nature of the surfactants. The aim of the work is to specify the quality of the
microspheres obtained (morphology, diameter, surface and efficiency of encapsulated API).
The results demonstrated that the prednisone encapsulation ratio depends on several parameters such as the nature
and concentration of the polymer used, the crosslinking agent and kind of surfactant. Morphological analysis by
optical microscopy and SEM confirms the presence of microparticles of spherical, porous shape and variable sizes.
The presence of Prednisone in the microparticles was confirmed by IRTF analysis which revealed the appearance
of additional absorption bands characteristic of Prednisone in the IR spectrum of the microparticles.

Article Details

Effect of Formulation Parameters on The Encapsulation of a Hydrophobic Active Ingredient Obtained by Ionic Gelation

Authors:

Lamoudi Lynda | Akreche Soraya | Daoud Kamel

Publisher:

Université des sciences et de la technologie Houari Boumediène alger

Journal:

Algerian Journal of Pharmaceutical Engineering , pp.1-4

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001543933

pISSN:

2992-0639

Microencapsulation ionic gelation Prednisone

sodium alginate calcium chloride

Issues

Article Details

Effect of Formulation Parameters on The Encapsulation of a Hydrophobic Active Ingredient Obtained by Ionic Gelation

Authors: Lamoudi Lynda | Akreche Soraya | Daoud Kamel

Publisher: Université des sciences et de la technologie Houari Boumediène alger

Journal: Algerian Journal of Pharmaceutical Engineering , pp.1-4

Document Type: Article

Publication Date: 3/2023

Document Language: English

Document ID (Org No.): 2001543933

pISSN: 2992-0639

Microencapsulation ionic gelation Prednisone

sodium alginate calcium chloride

Issues

Authors:

Lamoudi Lynda | Akreche Soraya | Daoud Kamel

Publisher:

Université des sciences et de la technologie Houari Boumediène alger

Journal:

Algerian Journal of Pharmaceutical Engineering , pp.1-4

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001543933

pISSN:

2992-0639