ADENOSINE A2A RECEPTOR ANTAGONISM INCREASED THE ANTIDEPRESSANT-LIKE EFFECT OF AMITRIPTYLINE IN MICE

Gülay SEZER

Article Details

ADENOSINE A2A RECEPTOR ANTAGONISM INCREASED THE ANTIDEPRESSANT-LIKE EFFECT OF AMITRIPTYLINE IN MICE

Authors:

Gülay SEZER

Publisher:

Erciyes University

Main Topics:

Promotion of health

Journal:

Journal of Health Sciences 2018 Vol.27 Issue 3, pp.205-210

Document Type:

Article

Publication Date:

12/2018

Document Language:

English

Document ID (Org No.):

2000613661

Frequency:

Tri-annual

pISSN:

1018-3655

Abstract:

 


Objective: The role of the endogenous adenosinergic
system in the peripheral effect of an antidepressant
drug, amitriptyline, has been demonstrated in pain
models and also in cardiovascular toxicity induced by
amitriptyline. We performed this study as there is no
information on whether adenosine or adenosine A2A
receptor antagonists have any effect on the
antidepressant-like activity of amitriptyline in mice.
Methods: Balb-c mice were used in experiments and
forced swimming test was used to evaluate the
antidepressant-like activity. Mice were injected with
saline (control), amitriptyline, SCH 58261 (A2A receptor
antagonist), SCH 58261 + amitriptyline, adenosine,
adenosine + amitriptyline, intraperitoneally.
Results: Amitriptyline decreased immobility time
compared to control group at both doses. SCH 58261
did not produce antidepressant like effect in the applied
dose alone. Pretreatment of amitriptyline with SCH
58261 produced stronger inhibition of immobility time
than amitriptyline induced alone in the same dose. Coadministration of adenosine with amitriptyine,
however, it was not decreased the anti-immobility effect
of amitriptyline. However, it was not statistically
significant.
Conclusion: It has been demonstrated that
adenosinergic system may have a role in the
antidepressant-like activity of amitriptyline in mice, and
pretreatment with the A2A receptor antagonist may
induce a more pronounced antidepressant-like activity.
We are of the opinion that this finding may be of
particular importance in the case of drug resistant
patients. 

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Article Details

ADENOSINE A2A RECEPTOR ANTAGONISM INCREASED THE ANTIDEPRESSANT-LIKE EFFECT OF AMITRIPTYLINE IN MICE

Authors: Gülay SEZER

Publisher: Erciyes University

Main Topics: Promotion of health

Journal: Journal of Health Sciences 2018 Vol.27 Issue 3, pp.205-210

Document Type: Article

Publication Date: 12/2018

Document Language: English

Document ID (Org No.): 2000613661

Frequency: Tri-annual

pISSN: 1018-3655

Issues

Authors:

Gülay SEZER

Publisher:

Erciyes University

Main Topics:

Promotion of health

Journal:

Journal of Health Sciences 2018 Vol.27 Issue 3, pp.205-210

Document Type:

Article

Publication Date:

12/2018

Document Language:

English

Document ID (Org No.):

2000613661

Frequency:

Tri-annual

pISSN:

1018-3655