Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

Peruze AYHAN EŞİYOK; Özlem SEVEN; Gülüzar EYMUR; Gamze BORA TATAR; Didem DAYANGAÇ ERDEN; Kemal YELEKÇİ; Hayat YURTER; Ayhan Sıtkı DEMİR

doi:https://doi.org/10.3906/kim-1305-56

Article Details

Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

Authors:

Peruze AYHAN EŞİYOK | Özlem SEVEN | Gülüzar EYMUR | Gamze BORA TATAR | Didem DAYANGAÇ ERDEN | Kemal YELEKÇİ | Hayat YURTER | Ayhan Sıtkı DEMİR

Publisher:

TUBITAK

Main Topics:

Chemistry and allied sciences

Journal:

Turkish Journal of Chemistry 2014 Vol.38 Issue 2, pp.338-344

Document Type:

Article

Publication Date:

5/2014

Document Language:

English

Document ID (Org No.):

2000727232

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1305-56

Abstract:

 

New aryl butenoic acid derivatives have been synthesized by combining  hydroxy- or methoxy-substituted phenyl rings as the capping group, with a  double bond in the short linker as well as metal binding groups, enoic  ester, and salts bearing either methyl or morpholine. These compounds have  been shown to possess promising histone deacetylase inhibition activities  via in vitro fluorometric assay and molecular docking studies.

 

New aryl butenoic acid derivatives have been synthesized by combining  hydroxy- or methoxy-substituted phenyl rings as the capping group, with a  double bond in the short linker as well as metal binding groups, enoic  ester, and salts bearing either methyl or morpholine. These compounds have  been shown to possess promising histone deacetylase inhibition activities  via in vitro fluorometric assay and molecular docking studies.

Article Details

Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: synthesis, in vitro evaluation, and molecular docking studies

Authors: Peruze AYHAN EŞİYOK | Özlem SEVEN | Gülüzar EYMUR | Gamze BORA TATAR | Didem DAYANGAÇ ERDEN | Kemal YELEKÇİ | Hayat YURTER | Ayhan Sıtkı DEMİR

Publisher: TUBITAK

Main Topics: Chemistry and allied sciences

Journal: Turkish Journal of Chemistry 2014 Vol.38 Issue 2, pp.338-344

Document Type: Article

Publication Date: 5/2014

Document Language: English

Document ID (Org No.): 2000727232

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

DOI: https://doi.org/10.3906/kim-1305-56

Issues

Authors:

Peruze AYHAN EŞİYOK | Özlem SEVEN | Gülüzar EYMUR | Gamze BORA TATAR | Didem DAYANGAÇ ERDEN | Kemal YELEKÇİ | Hayat YURTER | Ayhan Sıtkı DEMİR

Publisher:

TUBITAK

Main Topics:

Chemistry and allied sciences

Journal:

Turkish Journal of Chemistry 2014 Vol.38 Issue 2, pp.338-344

Document Type:

Article

Publication Date:

5/2014

Document Language:

English

Document ID (Org No.):

2000727232

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

DOI:

https://doi.org/10.3906/kim-1305-56