Presence, removal and environmental risk assessment of some analgesic and anti-inflammatory pharmaceuticals in urban wastewater and wastewater treatment plant

Arzu Ulvi; Senar Aydın; Mehmet Emin Aydın

Article Details

Presence, removal and environmental risk assessment of some analgesic and anti-inflammatory pharmaceuticals in urban wastewater and wastewater treatment plant

Authors:

Arzu Ulvi | Senar Aydın | Mehmet Emin Aydın

Publisher:

Nigde Omer Halisdemir University

Main Topics:

Çevre Mühendisliği

Journal:

Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi Vol.12 Issue 4, pp.1168-1175

Document Type:

Article

Publication Date:

10/2023

Document Language:

Turkish

Document ID (Org No.):

2001301221

pISSN:

2564-6605

Keywords:

Abstract:

 One of the important sources for pharmaceuticals to reach aquatic environments is wastewater treatment plant discharges. In this study, the presence and concentration of some analgesic and anti-inflammatory in the sewage system and the removal of these pharmaceuticals in Konya Wastewater Treatment Plant WWTP were determined. Ecological risk posed by pharmaceuticals discharged to the receiving environment with WWTP discharge has been evaluated for fish, Daphnia magna and algae. Extraction of samples taken from 22 different points of the sewage system and WWTP influent and effluent was carried out with a solid phase extraction system. Qualitative and quantitative analyzes of pharmaceuticals were performed by liquid chromatography mass spectrometry LC-MSMS. Mean concentrations of etodolac 3875 ngL, diclofenac 119 ngL, flurbiprofen 247912 ngL, naproxen 1827 ngL, paracetamol 7204 ngL, propyphenazone 2.23 ngL were detected in the sewage system. Mean concentrations were detected for etodolac 5080 ngL, 19688 ngL, for diclofenac 248 ngL, 962 ngL, for naproxen 1924 ngL, 97 ngL, for paracetamol 3286 ngL, 109 ngL, for propyphenazone 7.30 ngL, 20.9 ngL at the influent and effluent of the WWTP, respectively. Over 90 removal was observed for naproxen and paracetamol in the WWTP, and it was observed that other pharmaceuticals could not be removed in the plant. In the risk assessment made with the concentrations detected in the effluent, the RQ values were determined in the range of 4.3x10-5-2.6x10-2 and it poses an insignificant risk for the receiving environment. However, it should be kept in mind that pharmaceuticals are not the only pollutants found in receiving environments, they coexist with conventional and other micropollutants, and when their toxic effects are combined, they can create serious environmental problems. In addition, pharmaceuticals can accumulate in environment and living tissues, enter the food chain.

 One of the important sources for pharmaceuticals to reach aquatic environments is wastewater treatment plant discharges. In this study, the presence and concentration of some analgesic and anti-inflammatory in the sewage system and the removal of these pharmaceuticals in Konya Wastewater Treatment Plant WWTP were determined. Ecological risk posed by pharmaceuticals discharged to the receiving environment with WWTP discharge has been evaluated for fish, Daphnia magna and algae. Extraction of samples taken from 22 different points of the sewage system and WWTP influent and effluent was carried out with a solid phase extraction system. Qualitative and quantitative analyzes of pharmaceuticals were performed by liquid chromatography mass spectrometry LC-MSMS. Mean concentrations of etodolac 3875 ngL, diclofenac 119 ngL, flurbiprofen 247912 ngL, naproxen 1827 ngL, paracetamol 7204 ngL, propyphenazone 2.23 ngL were detected in the sewage system. Mean concentrations were detected for etodolac 5080 ngL, 19688 ngL, for diclofenac 248 ngL, 962 ngL, for naproxen 1924 ngL, 97 ngL, for paracetamol 3286 ngL, 109 ngL, for propyphenazone 7.30 ngL, 20.9 ngL at the influent and effluent of the WWTP, respectively. Over 90 removal was observed for naproxen and paracetamol in the WWTP, and it was observed that other pharmaceuticals could not be removed in the plant. In the risk assessment made with the concentrations detected in the effluent, the RQ values were determined in the range of 4.3x10-5-2.6x10-2 and it poses an insignificant risk for the receiving environment. However, it should be kept in mind that pharmaceuticals are not the only pollutants found in receiving environments, they coexist with conventional and other micropollutants, and when their toxic effects are combined, they can create serious environmental problems. In addition, pharmaceuticals can accumulate in environment and living tissues, enter the food chain.

 One of the important sources for pharmaceuticals to reach aquatic environments is wastewater treatment plant discharges. In this study, the presence and concentration of some analgesic and anti-inflammatory in the sewage system and the removal of these pharmaceuticals in Konya Wastewater Treatment Plant WWTP were determined. Ecological risk posed by pharmaceuticals discharged to the receiving environment with WWTP discharge has been evaluated for fish, Daphnia magna and algae. Extraction of samples taken from 22 different points of the sewage system and WWTP influent and effluent was carried out with a solid phase extraction system. Qualitative and quantitative analyzes of pharmaceuticals were performed by liquid chromatography mass spectrometry LC-MSMS. Mean concentrations of etodolac 3875 ngL, diclofenac 119 ngL, flurbiprofen 247912 ngL, naproxen 1827 ngL, paracetamol 7204 ngL, propyphenazone 2.23 ngL were detected in the sewage system. Mean concentrations were detected for etodolac 5080 ngL, 19688 ngL, for diclofenac 248 ngL, 962 ngL, for naproxen 1924 ngL, 97 ngL, for paracetamol 3286 ngL, 109 ngL, for propyphenazone 7.30 ngL, 20.9 ngL at the influent and effluent of the WWTP, respectively. Over 90 removal was observed for naproxen and paracetamol in the WWTP, and it was observed that other pharmaceuticals could not be removed in the plant. In the risk assessment made with the concentrations detected in the effluent, the RQ values were determined in the range of 4.3x10-5-2.6x10-2 and it poses an insignificant risk for the receiving environment. However, it should be kept in mind that pharmaceuticals are not the only pollutants found in receiving environments, they coexist with conventional and other micropollutants, and when their toxic effects are combined, they can create serious environmental problems. In addition, pharmaceuticals can accumulate in environment and living tissues, enter the food chain.

 Farmasötiklerin sucul çevrelere ulaşmasındaki önemli kaynaklardan bir tanesi atıksu arıtma tesisi deşarjlarıdır. Bu çalışmada, Konya kenti kanalizasyon sisteminde bazı analjezik ve anti-enflamatuarların varlığı ve konsantrasyonu, Konya Atıksu Arıtma Tesisin AATde bu farmasötiklerin giderimi belirlenmiştir. AAT deşarjı ile alıcı ortama deşarj edilen farmasötiklerin oluşturduğu ekotoksikolojik risk balık, Daphnia magna ve alg için değerlendirilmiştir. Kanalizasyon sisteminin 22 farklı noktasından ve ATT giriş-çıkışından alınan örneklerin ekstraksiyonu katı faz ekstraksiyonu ile, farmasötiklerin kalitatif ve kantitatif analizleri ise sıvı kromatografisi kütle spektrometresi LC-MSMS ile gerçekleştirilmiştir. Kanalizasyon sisteminde etodolac 3875 ngL, diclofenac 119 ngL, flurbiprofen 247912 ngL, naproxen 1827 ngL, paracetamol 7204 ngL, propyphenazone 2.23 ngL ortalama konsantrasyonlarında tespit edilmiştir. AAT giriş ve çıkışında ise sırasıyla etodolac 5080 ngL ve 19688 ngL, diclofenac 248 ngL ve 962 ngL, naproxen 1924 ngL ve 97.7 ngL, paracetamol 3286 ngL ve 109 ngL, propyphenazone 7.3 ngL ve 20.9 ngL ortalama konsantrasyonlarında tespit edilmiştir. AATde naproxen, paracetamol farmasötikleri için 90 üzerinde giderim gözlenmiş, diğer farmasötiklerin tesiste giderilemediği görülmüştür. Çıkış atıksuyunda tespit edilen konsantrasyonlar ile yapılan risk değerlendirmesinde risk oranı RQ değerleri 4.3x10-5-2.6x10-2 aralığında tespit edilmiştir ve alıcı ortam için önemsiz risk oluşturduğu belirlenmiştir. Buna rağmen, farmasötiklerin alıcı ortamlarda bulunan tek kirletici olmadığı, konvansiyonel ve diğer mikrokirleticilerle bir arada bulunduğu, hepsinin ayrı ayrı toksik etkileri birleştiğinde ciddi çevresel sorunlar oluşturabileceği unutulmamalıdır. Ayrıca, farmasötikler çevresel ortamlarda ve canlı dokularda birikebilir, besin zincirine taşınabilir.

Article Details

Presence, removal and environmental risk assessment of some analgesic and anti-inflammatory pharmaceuticals in urban wastewater and wastewater treatment plant

Authors:

Arzu Ulvi | Senar Aydın | Mehmet Emin Aydın

Publisher:

Nigde Omer Halisdemir University

Main Topics:

Çevre Mühendisliği

Journal:

Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi Vol.12 Issue 4, pp.1168-1175

Document Type:

Article

Publication Date:

10/2023

Document Language:

Turkish

Document ID (Org No.):

2001301221

pISSN:

2564-6605

Pharmaceutical

analgesic

anti-inflammatory

wastewater

removalFarmasötik

analjezik

anti-enflamatuar

atıksu

giderim

Issues

Article Details

Authors: Arzu Ulvi | Senar Aydın | Mehmet Emin Aydın

Publisher: Nigde Omer Halisdemir University

Main Topics: Çevre Mühendisliği

Journal: Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi Vol.12 Issue 4, pp.1168-1175

Document Type: Article

Publication Date: 10/2023

Document Language: Turkish

Document ID (Org No.): 2001301221

pISSN: 2564-6605

Issues

Authors:

Arzu Ulvi | Senar Aydın | Mehmet Emin Aydın

Publisher:

Nigde Omer Halisdemir University

Main Topics:

Çevre Mühendisliği

Journal:

Niğde Ömer Halisdemir Üniversitesi Mühendislik Bilimleri Dergisi Vol.12 Issue 4, pp.1168-1175

Document Type:

Article

Publication Date:

10/2023

Document Language:

Turkish

Document ID (Org No.):

2001301221

pISSN:

2564-6605