Macroscopic Evaluation of the Effect of Topically Applied Tideglusib with Bacterial Cellulose-Based Hydrogel Carrier on Healing of Palatal Wound in Rats: A Preliminary Study

Elif Var Odabaş; Semra Ünal Yıldırım; Oğuzhan Gündüz; Berna Alemdağ; Deniz Mukaddes Türet; Ömer Birkan Ağralı

Article Details

Macroscopic Evaluation of the Effect of Topically Applied Tideglusib with Bacterial Cellulose-Based Hydrogel Carrier on Healing of Palatal Wound in Rats: A Preliminary Study

Authors:

Elif Var Odabaş | Semra Ünal Yıldırım | Oğuzhan Gündüz | Berna Alemdağ | Deniz Mukaddes Türet | Ömer Birkan Ağralı

Publisher:

Marmara University

Main Topics:

Dentistry

Journal:

European Journal of Research in Dentistry Vol.7 Issue 2, pp.72-78

Document Type:

Article

Publication Date:

8/2023

Document Language:

Turkish

Document ID (Org No.):

2001297846

pISSN:

2630-6247

Keywords:

Abstract:

 Objectives: The aim of this study is to macroscopically evaluate the early effect of topically applied bacterial cellulose BC based hydrogel carrier including tideglusib Td on palatal wound in rats. Materials and Methods: The study group consisted of 3 months old male, 12 Sprague Dawley rats, each weighing an average of 250-300 gr. Three animals were instantly sacrificed and represented the baseline group at time 0 initial group. The remaining nine were divided into three groups at random: empty group, hydrogel group, Tdhydrogel group. Mean wound surface area was measured photographically. Results: In the intergroup comparison, a statistically significant difference was observed in the wound surface area p0.033. In the pairwise comparisons between the groups, a statistically significant difference was found only between the initial group and the TdHydrogel group p0,028. Conclusions: Td topically applied with BC based hydrogel has positive effects on palatal mucosal wound healing of rats.

 Objectives: The aim of this study is to macroscopically evaluate the early effect of topically applied bacterial cellulose BC based hydrogel carrier including tideglusib Td on palatal wound in rats. Materials and Methods: The study group consisted of 3 months old male, 12 Sprague Dawley rats, each weighing an average of 250-300 gr. Three animals were instantly sacrificed and represented the baseline group at time 0 initial group. The remaining nine were divided into three groups at random: empty group, hydrogel group, Tdhydrogel group. Mean wound surface area was measured photographically. Results: In the intergroup comparison, a statistically significant difference was observed in the wound surface area p0.033. In the pairwise comparisons between the groups, a statistically significant difference was found only between the initial group and the TdHydrogel group p0,028. Conclusions: Td topically applied with BC based hydrogel has positive effects on palatal mucosal wound healing of rats.

 Objectives: The aim of this study is to macroscopically evaluate the early effect of topically applied bacterial cellulose BC based hydrogel carrier including tideglusib Td on palatal wound in rats. Materials and Methods: The study group consisted of 3 months old male, 12 Sprague Dawley rats, each weighing an average of 250-300 gr. Three animals were instantly sacrificed and represented the baseline group at time 0 initial group. The remaining nine were divided into three groups at random: empty group, hydrogel group, Tdhydrogel group. Mean wound surface area was measured photographically. Results: In the intergroup comparison, a statistically significant difference was observed in the wound surface area p0.033. In the pairwise comparisons between the groups, a statistically significant difference was found only between the initial group and the TdHydrogel group p0,028. Conclusions: Td topically applied with BC based hydrogel has positive effects on palatal mucosal wound healing of rats.

 Amaç: Bu çalışmanın amacı, bakteriyel selüloz BS tabanlı hidrojel taşıyıcı ile topikal olarak uygulanan tideglusib Tdnin sıçanlarda oluşturulan palatinal yaranın iyileşmesi üzerindeki erken etkisini makroskobik olarak değerlendirmektir. Gereç ve Yöntemler: Bu çalışmada deney hayvanı olarak; ortalama 3 aylık, ağırlıkları 250-300 gr arasında değişen, 12 adet genç erişkin erkek Sprague Dawley sıçan kullanıldı. Sıçanların palatinal mukozalarının ortasında 4 mm çapında mukozal defekt oluşturuldu. Üç hayvan, defekt oluşturulduktan hemen sonra sakrifiye edildi ve başlangıç grubunu oluşturdu. Diğer 9 hayvan, pasif kontrol, sadece taşıyıcı uygulanan hidrojel ve taşıyıcı içinde Td uygulanan TdHidrojel olmak üzere rastgele üç gruba ayrıldı. Bu üç gruptaki hayvanlar 7. günde sakrifiye edildi. Ortalama yara yüzey alanı fotoğraf üzerinden ölçülerek makroskobik olarak değerlendirildi. Bulgular: Gruplar arası karşılaştırmada yara yüzey alanında istatistiksel olarak anlamlı farklılık gözlendi p0,033. Gruplar arası ikili karşılaştırmalarda sadece başlangıç grubu ile TdHidrojel grubu arasında istatistiksel olarak anlamlı bir fark bulundu p0,028. Sonuç: BS tabanlı hidrojel ile topikal olarak uygulanan Tdnin, sıçanların palatal mukozal yara iyileşmesi üzerinde olumlu etkilere sahip olduğu makroskobik olarak gösterilmiştir.

Article Details

Macroscopic Evaluation of the Effect of Topically Applied Tideglusib with Bacterial Cellulose-Based Hydrogel Carrier on Healing of Palatal Wound in Rats: A Preliminary Study

Authors:

Elif Var Odabaş | Semra Ünal Yıldırım | Oğuzhan Gündüz | Berna Alemdağ | Deniz Mukaddes Türet | Ömer Birkan Ağralı

Publisher:

Marmara University

Main Topics:

Dentistry

Journal:

European Journal of Research in Dentistry Vol.7 Issue 2, pp.72-78

Document Type:

Article

Publication Date:

8/2023

Document Language:

Turkish

Document ID (Org No.):

2001297846

pISSN:

2630-6247

wound healing

palatal mucosal healing

wound dressing

tideglusib

wnt signaling pathwayyara iyileşmesi

palatinal mukozal iyileşme

yara örtücü

tideglusib

wnt sinyal yolu

Issues

Article Details

Authors: Elif Var Odabaş | Semra Ünal Yıldırım | Oğuzhan Gündüz | Berna Alemdağ | Deniz Mukaddes Türet | Ömer Birkan Ağralı

Publisher: Marmara University

Main Topics: Dentistry

Journal: European Journal of Research in Dentistry Vol.7 Issue 2, pp.72-78

Document Type: Article

Publication Date: 8/2023

Document Language: Turkish

Document ID (Org No.): 2001297846

pISSN: 2630-6247

Issues

Authors:

Elif Var Odabaş | Semra Ünal Yıldırım | Oğuzhan Gündüz | Berna Alemdağ | Deniz Mukaddes Türet | Ömer Birkan Ağralı

Publisher:

Marmara University

Main Topics:

Dentistry

Journal:

European Journal of Research in Dentistry Vol.7 Issue 2, pp.72-78

Document Type:

Article

Publication Date:

8/2023

Document Language:

Turkish

Document ID (Org No.):

2001297846

pISSN:

2630-6247