Pan-immune inflammatory value a new diagnostic biomarker in postmenopausal osteoporosis

Pınar Özge Başaran; Duygu Tutan

Article Details

Pan-immune inflammatory value a new diagnostic biomarker in postmenopausal osteoporosis

Authors:

Pınar Özge Başaran | Duygu Tutan

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Endokrinoloji | Fiziksel Tıp ve Rehabilitasyon

Journal:

Journal of Medicine and Palliative Care Vol.5 Issue 2, pp.105-111

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001316669

pISSN:

2717-7505

Keywords:

Abstract:

 Aims: Postmenopausal osteoporosis PMOP is one of the most common bone diseases. We aimed to investigate the relationship between pan-immune inflammatory value and decreased bone mineral density in postmenopausal women. Methods: This prospective cross-sectional study was composed of 186 postmenopausal women. Osteoporosis was diagnosed with dualenergy Xray absorptiometry DEXA results according to World Health Organization WHO recommendations and patients were separated into 3 groups; 1. control group with a T-score -1; 2. group osteopenia with a T-score between -1.0 and -2.5; 3. group osteoporosis with a T-score -2.5. After the physical examinations of all patients, venous blood samples were collected and the pan-immune inflammation value PIV was calculated. The parameters were evaluated statistically with the PIV value between the groups. Results: Groups are similar in terms of age, menopausal age, education, and occupation. PIV was significantly higher in postmenopausal women with osteoporosis than women with osteopenia and the control group p0.001, p0.001. PIV was significantly higher in postmenopausal women with osteopenia than the control group p0.001. Distinguishing between osteoporosis and osteopenia, PIV 306.20 was 72.6 sensitivity, 69.4 specificity, and 71.7 negative predictive value. Distinguishing between osteopenia and control, PIV 152.02 was 85.5 sensitivity, 56.5 specificity, 66.3 positive predictive value, and 79.5 negative predictive value. Conclusion: In our study, we found that the PIV was statistically higher in PMOP, it was also statistically higher in postmenopausal women with osteopenia compared to healthy controls. We believe that PIV can be a cheap, easy, and reliable evaluation parameter for determining the risk of osteoporosis and osteopenia in women with PMOP.

 Aims: Postmenopausal osteoporosis PMOP is one of the most common bone diseases. We aimed to investigate the relationship between pan-immune inflammatory value and decreased bone mineral density in postmenopausal women. Methods: This prospective cross-sectional study was composed of 186 postmenopausal women. Osteoporosis was diagnosed with dualenergy Xray absorptiometry DEXA results according to World Health Organization WHO recommendations and patients were separated into 3 groups; 1. control group with a T-score -1; 2. group osteopenia with a T-score between -1.0 and -2.5; 3. group osteoporosis with a T-score -2.5. After the physical examinations of all patients, venous blood samples were collected and the pan-immune inflammation value PIV was calculated. The parameters were evaluated statistically with the PIV value between the groups. Results: Groups are similar in terms of age, menopausal age, education, and occupation. PIV was significantly higher in postmenopausal women with osteoporosis than women with osteopenia and the control group p0.001, p0.001. PIV was significantly higher in postmenopausal women with osteopenia than the control group p0.001. Distinguishing between osteoporosis and osteopenia, PIV 306.20 was 72.6 sensitivity, 69.4 specificity, and 71.7 negative predictive value. Distinguishing between osteopenia and control, PIV 152.02 was 85.5 sensitivity, 56.5 specificity, 66.3 positive predictive value, and 79.5 negative predictive value. Conclusion: In our study, we found that the PIV was statistically higher in PMOP, it was also statistically higher in postmenopausal women with osteopenia compared to healthy controls. We believe that PIV can be a cheap, easy, and reliable evaluation parameter for determining the risk of osteoporosis and osteopenia in women with PMOP.

 Aims: Postmenopausal osteoporosis PMOP is one of the most common bone diseases. We aimed to investigate the relationship between pan-immune inflammatory value and decreased bone mineral density in postmenopausal women. Methods: This prospective cross-sectional study was composed of 186 postmenopausal women. Osteoporosis was diagnosed with dualenergy Xray absorptiometry DEXA results according to World Health Organization WHO recommendations and patients were separated into 3 groups; 1. control group with a T-score -1; 2. group osteopenia with a T-score between -1.0 and -2.5; 3. group osteoporosis with a T-score -2.5. After the physical examinations of all patients, venous blood samples were collected and the pan-immune inflammation value PIV was calculated. The parameters were evaluated statistically with the PIV value between the groups. Results: Groups are similar in terms of age, menopausal age, education, and occupation. PIV was significantly higher in postmenopausal women with osteoporosis than women with osteopenia and the control group p0.001, p0.001. PIV was significantly higher in postmenopausal women with osteopenia than the control group p0.001. Distinguishing between osteoporosis and osteopenia, PIV 306.20 was 72.6 sensitivity, 69.4 specificity, and 71.7 negative predictive value. Distinguishing between osteopenia and control, PIV 152.02 was 85.5 sensitivity, 56.5 specificity, 66.3 positive predictive value, and 79.5 negative predictive value. Conclusion: In our study, we found that the PIV was statistically higher in PMOP, it was also statistically higher in postmenopausal women with osteopenia compared to healthy controls. We believe that PIV can be a cheap, easy, and reliable evaluation parameter for determining the risk of osteoporosis and osteopenia in women with PMOP.

 Amaç: Postmenopozal osteoporoz PMOP en yaygın kemik hastalıklarından biridir. Bu çalışmada postmenopozal kadınlarda pan-immün inflamatuar değer ile azalmış kemik mineral yoğunluğu arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntemler: Bu prospektif kesitsel çalışma 186 postmenopozal kadından oluşmaktadır. Osteoporoz tanısı Dünya Sağlık Örgütü WHO önerilerine göre dual-enerji X-ray absorpsiyometri DEXA sonuçları ile konuldu ve hastalar 3 gruba ayrıldı; 1. T-skoru -1 olan kontrol grubu; 2. T-skoru -1,0 ile -2,5 arasında olan osteopeni grubu; 3. T-skoru -2,5 olan osteoporoz grubu. Tüm hastaların fiziksel muayenelerinin ardından venöz kan örnekleri alındı ve pan-immün inflamasyon değeri PIV hesaplandı. Gruplar arasında PIV değeri ile osteoporoz düzeyi arasındaki ilişki istatistiksel olarak değerlendirildi. Bulgular: Gruplar yaş, menopoz yaşı, eğitim ve meslek açısından benzerdir. PIV değeri postmenopozal osteoporozlu kadınlarda osteopenili kadınlara ve kontrol grubuna göre anlamlı olarak daha yüksektir p0.001, p0.001. PIV, osteopenisi olan postmenopozal kadınlarda kontrol grubuna göre anlamlı derecede yüksektirp0.001. Osteoporoz ve osteopeni ayrımında, PIV 306.20 72.6 duyarlılık, 69.4 özgüllük ve 71.7 negatif prediktif değere sahiptir. Osteopeni ve sağlıklı kontrol arasındaki ayrımda, PIV 152.02 iken 85.5 duyarlılık, 56.5 özgüllük, 66.3 pozitif prediktif değer ve 79.5 negatif prediktif mevcuttur. Sonuç: Çalışmamızda, PIVnin PMOPde istatistiksel olarak daha yüksek olduğunu, ayrıca osteopenisi olan postmenopozal kadınlarda sağlıklı kontrollere kıyasla istatistiksel olarak daha yüksek olduğunu saptadık. PIVin PMOPlu kadınlarda osteoporoz ve osteopeni riskini belirlemede ucuz, kolay ve güvenilir bir değerlendirme parametresi olabileceğine inanıyoruz.

Article Details

Pan-immune inflammatory value a new diagnostic biomarker in postmenopausal osteoporosis

Authors:

Pınar Özge Başaran | Duygu Tutan

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Endokrinoloji | Fiziksel Tıp ve Rehabilitasyon

Journal:

Journal of Medicine and Palliative Care Vol.5 Issue 2, pp.105-111

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001316669

pISSN:

2717-7505

pan-immune-inflammatory value

postmenopausal osteoporosis

osteopeniaPan-immün inflamatuar değer

postmenopozal osteoporoz

osteopeni

Issues

Article Details

Pan-immune inflammatory value a new diagnostic biomarker in postmenopausal osteoporosis

Authors: Pınar Özge Başaran | Duygu Tutan

Publisher: MediHealth Academy Yayıncılık

Main Topics: Endokrinoloji | Fiziksel Tıp ve Rehabilitasyon

Journal: Journal of Medicine and Palliative Care Vol.5 Issue 2, pp.105-111

Document Type: Article

Publication Date: 4/2024

Document Language: English

Document ID (Org No.): 2001316669

pISSN: 2717-7505

pan-immune-inflammatory value

postmenopausal osteoporosis

osteopeniaPan-immün inflamatuar değer

postmenopozal osteoporoz

osteopeni

Issues

Authors:

Pınar Özge Başaran | Duygu Tutan

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Endokrinoloji | Fiziksel Tıp ve Rehabilitasyon

Journal:

Journal of Medicine and Palliative Care Vol.5 Issue 2, pp.105-111

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001316669

pISSN:

2717-7505